Results 251 to 260 of about 136,719 (278)

N6‐Methyladenosine in Inflammatory Bowel Disease: An Emerging Regulator of Pathogenesis and a Novel Therapeutic Frontier

iMetaMed, EarlyView.
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine associated with an imbalance in intestinal homeostasis. m6A‐modifying enzymes, consisting of m6A writers, erasers and readers, plays a pivotal role in the pathogenesis and progression of IBD by affecting four intestinal barriers, including the intestinal mechanical ...
Jiaxian Guo, Yang Zhang, Xin Wang, Shan Cao, Jun Xu   +4 more
wiley   +1 more source

Neuroprotection by canagliflozin in a Huntington's disease model: role of HIF-1α and PI3K/AKT signaling. [PDF]

Naunyn Schmiedebergs Arch Pharmacol
Elgindy AM, El-Awady EE, El-Sayed NM, El-Orabi NF, Atwa AM.   +4 more
europepmc   +1 more source

Association of serums HIF-1α and HIF-2α with the levels and severity of renal fibrosis: a retrospective cohort study. [PDF]

BMC Nephrol
Zhang X, Zhang W, Waheed YA, Li S, Sun D.   +4 more
europepmc   +1 more source

Rhizoma Dioscoreae Nipponicae attenuates airway remodeling and angiogenesis-related changes in asthma with altered mTOR/4EBP1/HIF-1α/VEGF pathway markers. [PDF]

World Allergy Organ J
Zhou X, Wang Z, Zheng S.
europepmc   +1 more source

Clinically approved HIF-PHIs modulate redox metabolism, cell growth, and angiogenesis independent of HIF-1α/HIF-2α. [PDF]

Redox Biol
Mennerich D, Khoder-Agha F, Beter M, Dimova EY, Ylä-Herttuala S, Kietzmann T.   +5 more
europepmc   +1 more source

CircRSU1 Activates the hnRNPA1/HIF-1α/CD24 Signaling Axis, Promoting Stemness Features of Hepatocellular Carcinoma. [PDF]

Adv Sci (Weinh)
Xue S, Wei D, Zhao Y, Pan J, Zhang H, Liu N, Zhang J, Liu J, Jin J, Xiao M, Feng X, Lin A, Zhao L, Roessler S, Ji J.   +14 more
europepmc   +1 more source

HIF-1α at the intersection of hypoxia, ferroptosis-associated stress, and cell death crosstalk in osteomyelitis. [PDF]

Front Cell Dev Biol
Li J, Yang F, Deng X, Yu Y, Huang X, Yang X, Yang L, Zhang T, Xiong H.   +8 more
europepmc   +1 more source

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HIF-1α protein expression is associated with the environmental inflammatory reaction in Barrett's metaplasia

Diseases of the Esophagus, 2009
The oxygen-regulated transcription factor subunit hypoxia inducible factor-1alpha (HIF-1alpha) is involved in angiogenesis, energy metabolism, cell survival, and inflammation. We examined the protein expression of HIF-1alpha within the progression of Barrett's sequence as well as the type and degree of the environmental inflammatory reaction.
Ling, F C, Khochfar, J, Baldus, S E, Brabender, J, Drebber, U, Bollschweiler, E, Hoelscher, A H, Schneider, P M   +7 more
openaire   +3 more sources

HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1α degradation [PDF]

FEBS Letters, 2001
Hypoxia-inducible factor-1α (HIF-1α) plays a central role in oxygen homeostasis. In normoxia, HIF-1α is a short lived protein, whereas hypoxia rapidly increases HIF-1α protein levels by relaxing its ubiquitin–proteasome-dependent degradation.
Edurne Berra, Darren E Richard, Jacques Pouyssegur   +2 more
exaly   +2 more sources

Revisiting the HIF switch in the tumor and its immune microenvironment

Trends in Cancer, 2022
Mei Yee Koh
exaly