Results 41 to 50 of about 135,194 (207)
Loss of ATF3 exacerbates liver damage through the activation of mTOR/p70S6K/ HIF-1α signaling pathway in liver inflammatory injury. [PDF]
, 2018 Activating transcription factor 3 (ATF3) is a stress-induced transcription factor that plays important roles in regulating immune and metabolic homeostasis.
Jiang, Bin +9 more
core +2 more sources
Silencing HIF-1α reduces the adhesion and secretion functions of acute leukemia hBMSCs
Brazilian Journal of Medical and Biological Research, 2012 Hypoxia inducible factor-1α (HIF-1α) is an important transcription factor, which plays a critical role in the formation of solid tumor and its microenviroment.
Zeng Dong-Feng +6 more
doaj +1 more source
The relationship between expression of PD-L1 and HIF-1α in glioma cells under hypoxia
Journal of Hematology & Oncology, 2021 Hypoxia inducible factor-1α (HIF-1α) up-regulates the expression of programmed death ligand-1 (PD-L1) in some extracranial malignancies. However, whether it could increase PD-L1 expression in intracranial tumor is still unknown.
Xing-chen Ding +12 more
doaj +1 more source
Zhongliu Fangzhi Yanjiu, 2021 Objective To explore the mechanism of HIF-1α promoting malignant development of nasopharyngeal carcinoma by upregulating PD-L1 expression under hypoxic conditions.
JIANG Doudou +3 more
doaj +1 more source
Overcoming evasive resistance from vascular endothelial growth factor a inhibition in sarcomas by genetic or pharmacologic targeting of hypoxia-inducible factor 1α [PDF]
, 2012 Increased levels of hypoxia and hypoxia-inducible factor 1α (HIF-1α) in human sarcomas correlate with tumor progression and radiation resistance. Prolonged antiangiogenic therapy of tumors not only delays tumor growth but may also increase hypoxia and ...
Eisinger-Mathason, TS Karin +10 more
core +1 more source
Frontiers in Medicine, 2022 It is well-established that mitophagy leads to Diabetic Nephropathy (DN) and renal failure. Mitophagy mediated by a Hypoxia-inducible factor-1α (HIF-1α) plays a beneficial role in many diseases.
Lu Yu +6 more
doaj +1 more source
Hypoxia in the Initiation and Progression of Neuroblastoma Tumours [PDF]
, 2020 Neuroblastoma is the most frequent extracranial solid tumour in children, causing 10% of all paediatric oncology deaths. It arises in the embryonic neural crest due to an uncontrolled behaviour of sympathetic nervous system progenitors, giving rise to ...
Gómez Muñoz, María Ángeles +3 more
core +1 more source
Cancer Medicine, 2019 Objective To investigate the expression level and potential mechanism of hypoxia‐inducible factor 1 alpha (HIF‐1α) in patients with myelodysplastic syndromes (MDS). Methods Immunohistochemistry (IHC) techniques were used to examine the protein expression
Hai‐wei Liang +6 more
doaj +1 more source
Diagnostics, 2023 Hypoxia-inducible factor-1α (HIF-1α) has been shown to be involved in cancer metastasis in several cancer types. There is however conflicting evidence of HIF-1α expression with oral cancer prognosis.
Sumera Sumera +6 more
doaj +1 more source
Assessment of HIF-1α expression and release following endothelial injury in-vitro and in-vivo [PDF]
, 2018 Background: Endothelial injury is an early and enduring feature of cardiovascular disease. Inflammation and hypoxia may be responsible for this, and are often associated with the up-regulation of several transcriptional factors that include Hypoxia ...
A Gorlach +36 more
core +1 more source