Results 71 to 80 of about 135,194 (207)

A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells [PDF]

, 2013
Hypoxia inducible factor-1 (HIF-1) is a heterodimeric transcription factor that acts as the master regulator of cellular response to reduced oxygen levels, thus playing a key role in the adaptation, survival and progression of tumors.
Court, William, Cuda, F., Eccles, Suzanne A., Fox, Keith R., Hoakwie, Franciane, Lawrence, Charlotte, Male, Abigail, Miranda, Elena, Nordgren, Ida, Packham, Graham K., Tavassoli, Ali, Townsend, Paul   +11 more
core   +1 more source

Hypoxia-inducible factor 1 alpha is a poor prognostic factor and potential therapeutic target in malignant peripheral nerve sheath tumor. [PDF]

PLoS ONE, 2017
BACKGROUND:Malignant peripheral nerve sheath tumor (MPNST) is a rare soft tissue sarcoma with poor prognosis. Hypoxia-inducible factor 1 (HIF-1) plays a crucial role in the cellular response to hypoxia and regulates the expression of multiple genes ...
Suguru Fukushima, Makoto Endo, Yoshihiro Matsumoto, Jun-Ichi Fukushi, Tomoya Matsunobu, Ken-Ichi Kawaguchi, Nokitaka Setsu, Keiichiro IIda, Nobuhiko Yokoyama, Makoto Nakagawa, Kenichiro Yahiro, Yoshinao Oda, Yukihide Iwamoto, Yasuharu Nakashima   +13 more
doaj   +1 more source

A long-term "memory" of HIF induction in response to chronic mild decreased oxygen after oxygen normalization [PDF]

, 2007
Background Endothelial dysfunction (ED) is functionally characterized by decreased vasorelaxation, increased thrombosis, increased inflammation, and altered angiogenic potential, has been intimately associated with the progression and severity of ...
Ceriello, Antonio, Green, Dixy E., Ihnat, Michael A., Kamat, Chandrashekhar D., Shenoy, Satyendra S, Thorpe, Jessica E, Warnke, Linda A.   +6 more
core   +3 more sources

Hypoxia‐inducible factor (HIF)‐1α‐induced regulation of lung injury in pulmonary aspiration is mediated through NF‐kB

FASEB BioAdvances, 2022
Aspiration‐induced lung injury is a common grievance encountered in the intensive care unit (ICU). It is a significant risk factor for improving ventilator‐associated pneumonia (VAP) and acute respiratory distress syndrome (ARDS).
Madathilparambil V. Suresh, George Yalamanchili, Tejeshwar C. Rao, Sinan Aktay, Alex Kralovich, Yatrik M. Shah, Krishnan Raghavendran   +6 more
doaj   +1 more source

Hypoxia inducible factors and hypoxia associated factor expression profiles and prognostic significance in renal cell carcinomas

Medicine Science, 2023
Hypoxia Inducible Factor-1 alpha and Hypoxia Inducible Factor-2 alpha (HIF-1α and HIF-2α) are crucial in Renal Cell Carcinoma (RCC) formation. Hypoxia Associated Factor (HAF) prompts HIF-1α degradation regardless of oxygen levels, but no such link exists
Merve Meryem Kiran, Nuran Sungu, Hayriye Tatli Dogan, Arslan Ardicoglu, Fazli Erdogan, Berrak Gumuskaya   +5 more
doaj   +1 more source

Hypoxia-inducible factor-1α as a biomarker for individuals under hypoxia duration and pattern in fat greenling Hexagrammos otakii

Aquaculture Reports
Background: One common environmental stressor in fisheries is hypoxia stress, which frequently causes significant fish mortality and financial losses. This study aimed to examine the potential utility of serum concentrations of hypoxia-inducible factor ...
Yu Zhan, Xin Qi, Yiting Wu, Dongxu Gao, Ling Zhao, Shengnan Cao, Zhuang Xue, Wei Wang   +7 more
doaj   +1 more source

Downregulation of Hypoxia-Inducible Factor-1α by RNA Interference Alleviates the Development of Collagen-Induced Arthritis in Rats

Molecular Therapy: Nucleic Acids, 2020
Rheumatoid arthritis (RA) is the most common type of autoimmune arthritis. Hypoxia-inducible factor-1α (HIF-1α) as a transcription factor in response to hypoxia suggests that it could be a potential therapeutic target for the treatment of RA.
Yiping Hu, Tiantian Zhang, Jingqin Chen, WenXiang Cheng, Jianhai Chen, Zhengtan Zheng, Jietao Lin, Guoyuan Zhu, Yong Zhang, Xueling Bai, Yan Wang, Bing Song, Qingwen Wang, Ling Qin, Peng Zhang   +14 more
doaj   +1 more source

Hypoxia-inducible factor 1 alpha expression increases during colorectal carcinogenesis and tumor progression

BMC Cancer, 2008
Background Hypoxia-inducible factor 1 alpha (HIF-1α) is involved in processes promoting carcinogenesis of many tumors. However, its role in the development of colorectal cancer is unknown.
Jayasinghe Caren, Taxeidis Marios, Simiantonaki Nektaria, Kurzik-Dumke Ursula, Kirkpatrick Charles   +4 more
doaj   +1 more source

The effects of hypoxia-inducible factors-1α and -2α and erythroferrone on hepcidin in patients with chronic kidney disease stages 3–5 and renal anemia

European Journal of Inflammation, 2022
Objective This study aimed to investigate the effects of hypoxia-inducible factor-1α (HIF-1α), hypoxia-inducible factor-2α (HIF-2α), and erythroferrone (ERFE) on hepcidin in patients with chronic kidney disease (CKD) stages 3–5 and renal anemia.
Jianghuai Hong, Jingjing Lai, Xiaoying Chen, Yan Yan, Yanyan Hong, Hailun Ke, Jing Zheng   +6 more
doaj   +1 more source

STAT3, a hub protein of cellular signaling pathways, is triggered by β-hexaclorocyclohexane [PDF]

, 2018
Background: Organochlorine pesticides (OCPs) are widely distributed in the environment and their toxicity is mostly associated with the molecular mechanisms of endocrine disruption.
Altieri, F, Carissimi, S, Chichiarelli, S, Eufemi, M, Giamogante, F, Macone, A, Paglia, G, Rubini, E   +7 more
core   +2 more sources