Results 91 to 100 of about 896,517 (311)

Growth Differentiation Factor 15 Elevation in the Central Nervous System Is Associated With Failure to Thrive in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Alexander disease (AxD) is a severe neurodegenerative disorder caused by gain‐of‐function mutations in the gene for GFAP, which lead to protein aggregation and a primary astrocytopathy. Symptoms vary, but failure to thrive (FTT) and frequent emesis are common and cause significant morbidity. Here we investigate GDF15, a member of the
Tracy L. Hagemann, Michelle M. Sonsalla, Cora Luzinski, Fernando Zacahua, David A. Harris, Dudley W. Lamming, Albee Messing   +6 more
wiley   +1 more source

The Personalized Nutrition Study (POINTS): evaluation of a genetically informed weight loss approach, a Randomized Clinical Trial

Nature Communications, 2023
Weight loss (WL) differences between isocaloric high-carbohydrate and high-fat diets are generally small; however, individual WL varies within diet groups.
Christoph Höchsmann, Shengping Yang, José M. Ordovás, James L. Dorling, Catherine M. Champagne, John W. Apolzan, Frank L. Greenway, Michelle I. Cardel, Gary D. Foster, Corby K. Martin   +9 more
doaj   +1 more source

Imaging of Lipid Droplets in Living Cells and Mice with Metabolic Dysfunction‐Associated Steatotic Liver Disease via a Galactose‐Modified Supramolecular Near‐Infrared Fluorescent Glycoprobe

Advanced Functional Materials, EarlyView.
A galactose‐modified supramolecular near‐infrared (NIR) glycoprobe, TCF‐FBN@Gal‐BSA, enables targeted delivery to the liver through the asialoglycoprotein receptor (ASGPR) and facilitates liver‐targeting fluorescence visualization of lipid droplets (LDs) in metabolic dysfunction‐associated steatotic liver disease (MASLD) mice.
Han‐Min Wang, Lei Dong, Qiu‐Lian Hao, Lu‐Lu Sun, Xin‐Rong Li, Yu‐Wei Yuan, Ming‐Ye Tang, Jin Gong, Yi Zang, Jia Li, Tony D. James, Xiao‐Peng He, Hai‐Hao Han   +12 more
wiley   +1 more source

Dual‐Nanoparticle Engineered Hydrogel Reverses Bicellular Oxidative Stress to Accelerate Diabetic Fracture Healing

Advanced Functional Materials, EarlyView.
CD105‐LNPs and PS‐LNPs can deliver α‐lipoic acid to bone marrow mesenchymal stem cells and bone marrow‐derived macrophages, reversing high glucose‐induced oxidative stress while enhancing osteogenesis and M2 polarization. Integrating both nanoparticles into glucose‐responsive hyaluronic acid hydrogel forms DLNPs@HA hydrogel, which accelerates diabetic ...
Yanzhi Zhao, Weixian Hu, Shengming Zhang, Yuheng Liao, Kangkang Zha, Chenyan Yu, Zhenhe Zhang, Wenqian Zhang, Bobin Mi, Faqi Cao, Guohui Liu, Wu Zhou   +11 more
wiley   +1 more source

Catechins inhibit atherosclerosis in male rats on a high fat diet

Universa Medicina, 2015
Background A catechin isolate from the green tea clone GMB 4, which shows antioxidant activity, may be a candidate drug for prevention of atherosclerosis.
Erna Susanti, Achmad Rudijanto, Retty Ratnawati   +2 more
doaj   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Hearts from mice fed a non-obesogenic high-fat diet exhibit changes in their oxidative state, calcium and mitochondria in parallel with increased susceptibility to reperfusion injury.

PLoS ONE, 2014
RationaleHigh-fat diet with obesity-associated co-morbidities triggers cardiac remodeling and renders the heart more vulnerable to ischemia/reperfusion injury.
Ben Littlejohns, Philippe Pasdois, Simon Duggan, Andrew R Bond, Kate Heesom, Christopher L Jackson, Gianni D Angelini, Andrew P Halestrap, M-Saadeh Suleiman   +8 more
doaj   +1 more source

High fat diet rescues disturbances to metabolic homeostasis and survival in the Id2 null mouse in a sex-specific manner [PDF]

, 2014
Inhibitor of DNA binding 2 (ID2) is a helix-loop-helix transcriptional repressor rhythmically expressed in many adult tissues. Our previous studies have demonstrated that Id2 null mice have altered expression of circadian genes involved in lipid ...
Dong, X. Charlie, Duffield, Giles E., Hummel, Alyssa D., Pywell, Cameron M., Zhou, Peng   +4 more
core   +1 more source

The Hierarchical Structure of Sheep Wool and Its Impact on Physical Properties

Advanced Functional Materials, EarlyView.
Sheep wool, a prevalent α‐keratinous fiber, is an essential model for studying protein‐based fibers. Its genetic diversity across breeds enables the establishment of multiscale structure‐property relationships, uncovering previously elusive insights into wool's hierarchical structure.
Serafina R. France Tribe, Paloma X. Lee, Caterina Czibula, Mónica G. Simões, Reiner Bleher, Keith E. Duncan, Michael Thoman, Christopher N. Topp, Vinayak P. Dravid, Cécile A. C. Chazot   +9 more
wiley   +1 more source

High-fat diet did not change metabolic response to acute stress in rats [PDF]

, 2011
This study investigated the effects of high-fat diet on metabolic factors in the presence of acute foot-shock and psychological stresses in male Wistar rats.
Farrokhi, Babak, Ghalami, Jamileh, Hedayati, Mehdi, Rostamkhani, Fatemeh, Zardooz, Homeira   +4 more
core