Results 111 to 120 of about 620,339 (314)

Effects of Continuous Exercise and Silymarin Supplementation on Tumor Necrosis Factor-alpha (TNF-a) and Liver Leptin in Male Wistar Rats with Fatty Liver Disease

مجله دانشگاه علوم پزشکی گرگان, 2023
Background and Objective: Leptin is associated with metabolic disorders and promotes the development of liver steatosis to steatohepatitis. It selectively increases the secretion of Tumor-necrosis factor-α (TNF-a) in response to saturated fatty acid. The
Minoo Dadban Shahamat, Asra Askari, Fatemeh Habibollahi   +2 more
doaj  

Dietary Uncoupling of Gut Microbiota and Energy Harvesting from Obesity and Glucose Tolerance in Mice

Cell Reports, 2017
Summary: Evidence suggests that altered gut microbiota composition may be involved in the development of obesity. Studies using mice made obese with refined high-fat diets have supported this; however, these have commonly used chow as a control diet ...
Matthew J. Dalby, Alexander W. Ross, Alan W. Walker, Peter J. Morgan   +3 more
doaj   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

The relationship between proportions of carbohydrate and fat intake and hyperglycaemia risk in Chinese adults

Public Health Nutrition
Objective: To address the relationship between the proportions of carbohydrates and fat and hyperglycaemia in the Chinese population. Design: A cross-section research involving data from the China Health and Nutrition Survey in 2009, and nutritional ...
Yayun Fan, Qingqing Huang, Honglan Gao, Fengying Huang, Dingliu He   +4 more
doaj   +1 more source

Probiotics modify tight-junction proteins in an animal model of nonalcoholic fatty liver disease

Therapeutic Advances in Gastroenterology, 2016
Background: We have investigated the effects of a multispecies probiotic preparation containing a combination of probiotic bacterial genera that included Bifidobacteria, Lactobacilli and a Streptococcus in a mouse model of high-fat diet or obesity ...
David Briskey, Mandy Heritage, Lesley-Anne Jaskowski, Jonathan Peake, Glenda Gobe, V. Nathan Subramaniam, Darrell Crawford, Catherine Campbell, Luis Vitetta   +8 more
doaj   +1 more source

Hepatocyte PIEZO1 Negatively Regulates Lipogenesis and Ameliorates MASLD by Sensing Membrane Tension and Activating AMPK

Advanced Science, EarlyView.
Hepatocytes are subjected to increased membrane tension along with lipid accumulation. Loss of PIEZO1 exacerbates high‐fat diet‐induced MASLD in mice. Activation of PIEZO1 alleviates high‐fat diet‐induced MASLD in mice. PIEZO1 negatively regulates de novo lipogenesis through activation of CaMKK2‐AMPK pathway. ABSTRACT Liver is a central organ for lipid
Hui Chen, Qimeng Wang, Ke Yang, Qinghai Lian, Xuyun Peng, Zhiyong Gong, Xinyi Zhao, Yong Wu, Tian Tao, Siqi Xu, Yifan Chen, Xiaoyan Tang, Jinghui Guo, Geyang Xu, Qi Zhang   +14 more
wiley   +1 more source

Catechins inhibit atherosclerosis in male rats on a high fat diet [PDF]

Universa Medicina, 2012
Background A catechin isolate from the green tea clone GMB 4, which shows antioxidant activity, may be a candidate drug for prevention of atherosclerosis.
Erna Susanti, Achmad Rudijanto, Retty Ratnawati   +2 more
doaj  

Data_Sheet_1_Honokiol Ameliorates High-Fat-Diet-Induced Obesity of Different Sexes of Mice by Modulating the Composition of the Gut Microbiota.XLS

, 2019
Background: Accumulating data support the fact that the gut microbiota plays an important role in the progression of obesity and its related metabolic disease.
Zhiyong Fan (785742), Tingli Pan (8111963), Zehe Song (3723604), Xueling Gu (8111966), Xi He (208289), Ling Chang (1862701), Yanan Ding (2214262), Hao Li (31608)   +7 more
core   +1 more source

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

Advanced Science, EarlyView.
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu, Bingwei Wang, Zhijie Su, Xiaoxv Han, Miao He, Yun Zhao, Yujia Hou, Daotong Li, Weiguang Zhang, Lihua Qin, Ke Wang, Yanchun Li, Yi Yan, Siwang Yu, Xiaoshuai Huang, Tairan Yuwen, Jianyuan Luo, Ruimao Zheng   +17 more
wiley   +1 more source

Table_1_Honokiol Ameliorates High-Fat-Diet-Induced Obesity of Different Sexes of Mice by Modulating the Composition of the Gut Microbiota.DOC

, 2019
Background: Accumulating data support the fact that the gut microbiota plays an important role in the progression of obesity and its related metabolic disease.
Zhiyong Fan (785742), Tingli Pan (8111963), Zehe Song (3723604), Xueling Gu (8111966), Xi He (208289), Ling Chang (1862701), Yanan Ding (2214262), Hao Li (31608)   +7 more
core   +1 more source