Results 71 to 80 of about 926,705 (358)

Effects of Persian leek (Allium ampeloprasum) on hepatic lipids and the expression of proinflammatory gene in hamsters fed a high-fat/ high-cholesterol diet [PDF]

Avicenna Journal of Phytomedicine, 2016
Objective: Persian leek is one of the most widely used herbal foods among Iranians. In this study, effects of oral administration of Persian leek on plasma and liver lipids were examined in hamster.
Vahideh Fatoorechi, Marjan Rismanchi, Javad Nasrollahzadeh   +2 more
doaj  

Dietary nano-Se supplementation regulates lipid deposition, protein synthesis and muscle fibre formation in grass carp fed with high-fat diet [PDF]

, 2023
Sha Liu, Haibo Yu, Lingwei Zhu, Xiaotian Zhang, Pengju Li, Chi Wang, Guohao Liu, Pan He, Cheng Zhang, Hong Ji   +9 more
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Hemin Improves Insulin Sensitivity in Skeletal Muscle in High Fat–Fed Mice

Journal of Pharmacological Sciences, 2014
.: The present study examined whether hemin could prevent the development of high-fat diet–induced insulin resistance in the liver and skeletal muscle using a hyperinsulinemic-euglycemic clamp.
Tae-Jin Ju, Woo-Young Kwon, Yong-Woon Kim, Jong-Yeon Kim, Yong-Dae Kim, In-Kyu Lee, So-Young Park   +6 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Metabolic dysfunctions promoted by AIN-93G standard diet compared with three obesity-inducing diets in C57BL/6J mice

Current Research in Physiology, 2022
Researchers from different fields have studied the causes of obesity and associated comorbidities, proposing ways to prevent and treat this condition by using a common animal model of obesity to create a profound energy imbalance in young adult rodents ...
Lais Marinho Aguiar, Carolina Soares de Moura, Cintia Reis Ballard, Aline Rissetti Roquetto, Juliana Kelly da Silva Maia, Gustavo H.B. Duarte, Larissa Bastos Eloy da Costa, Adriana Souza Torsoni, Jaime Amaya-Farfan, Mário R. Maróstica Junior, Cinthia Baú Betim Cazarin   +10 more
doaj   +1 more source

Sources of hepatic triglyceride accumulation during high-fat feeding in the healthy rat [PDF]

, 2009
Hepatic triglyceride (HTG) accumulation from peripheral dietary sources and from endogenous de novo lipogenesis (DNL) was quantified in adult Sprague-Dawley rats by combining in vivo localized 1H MRS measurement of total hepatic lipid with a novel ex ...
Caldeira, M., Castro, M. M. C. A., Cerdán, S., Delgado, T. C., Geraldes, C. F. G. C., Jones, J. G., López-Larrubia, P., Pinheiro, D.   +7 more
core   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Sphingolipids in High Fat Diet and Obesity-Related Diseases

Mediators of Inflammation, 2015
Nutrient oversupply associated with a high fat diet (HFD) significantly alters cellular metabolism, and specifically including sphingolipid metabolism.
Songhwa Choi, Ashley J. Snider
doaj   +1 more source

Intersection between metabolic dysfunction, high fat diet consumption, and brain aging [PDF]

, 2010
Deleterious neurochemical, structural, and behavioral alterations are a seemingly unavoidable aspect of brain aging. However, the basis for these alterations, as well as the basis for the tremendous variability in regards to the degree to which these ...
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core   +1 more source