Results 71 to 80 of about 10,771 (216)

Role of IAPs in prostate cancer progression: immunohistochemical study in normal and pathological (benign hyperplastic, prostatic intraepithelial neoplasia and cancer) human prostate

BMC Cancer, 2010
Background In this study was investigate IAPs in normal human prostate (NP), benign prostatic hyperplasia (BPH), prostatic intraepithelial neoplasia (PIN) and prostatic carcinoma (PC), and their involvement in apoptosis/proliferation via NF-kB (TNF-α, IL-
Olmedilla Gabriel, Martínez-Onsurbe Pilar, Prati Bruna, Nuñez Claudia, Bartolome Nahikari, Prieto-Folgado Angela, de Bethencourt Fermín R, Fraile Benito, Rodríguez-Berriguete Gonzalo, Paniagua Ricardo, Royuela Mar   +10 more
doaj   +1 more source

Evaluation of immunoexpression and MDR1 promoter methylation levels in prostatic tissue samples [PDF]

, 2008
Os objectivos deste estudo foram: (1) Determinar os níveis de metilação do promotor do MDR1 em tecido prostático com adenocarcinoma (CaP), neoplasia intraepitelial prostática de alto grau (HGPIN), hiperplasia benigna (BPH) e tecido morfologicamente ...
Costa, Vera L., Henrique, Rui, Jerónimo, Carmen, Moura, Inês, Pais, Irene, Ribeiro, Franclim R.   +5 more
core  

The concordance between the volume hotspot and the grade hotspot: a 3-D reconstructive model using the pathology outputs from the PROMIS trial. [PDF]

, 2016
The rationale for directing targeted biopsy towards the centre of lesions has been questioned in light of prostate cancer grade heterogeneity. In this study, we assess the assumption that the maximum cancer Gleason grade (Gleason grade hotspot) lies ...
A El-Shater Bosaily, A El-Shater Bosaily, A Freeman, A Oto, A Sciarra, AC Reese, C Jameson, CM Hoeks, D Barratt, E Lecornet, ED Crawford, ET Ruijter, F Algaba, FH Schroder, G Onik, GL Shaw, H U Ahmed, HU Ahmed, J Hugosson, J Qian, JO Barentsz, L Brown, L Egevad, L Holmberg, M de Rooij, M Djulbegovic, M Emberton, M Valerio, M Valerio, NL Robertson, R G Hindley, R Kaplan, S Kaufmann, T Hambrock, TH Van der Kwast, TJ Wilt, WJ van de Ven, Y Hu, Y Itou   +38 more
core   +2 more sources

Immune Exhaustion in Chronic Infection and Cancer: Signaling Pathways and Therapeutic Interventions

MedComm, Volume 7, Issue 3, March 2026.
Immune exhaustion is a well‐established hallmark of both cancer and chronic infection. This review proposes a novel “infection–exhaustion–tumor axis” framework, wherein chronic pathogens (e.g., oncogenic viruses) evade immune surveillance by hijacking inflammatory signaling to drive immune cell exhaustion, thereby creating immunosuppressive niches ...
Yali Song, Yazhi Mo, Si Chen, Yuemei Chen, Chunying Zhang, Shanying Deng, Juan Liao, Yi He, Wei Wang, Weidong Zheng, Tingting Zeng   +10 more
wiley   +1 more source

Early Cancer Detection: What's Going on and What's Next

MedComm, Volume 7, Issue 3, March 2026.
Multicancer early detection (MCED) platforms have emerged as a promising strategy for the safe and effective early detection of multiple cancer types, with the potential to reduce metastatic burden and improve clinical outcomes, particularly for aggressive malignancies that lack effective population‐level screening.
Emma Di Carlo
wiley   +1 more source

Foamy gland high-grade prostatic intraepithelial neoplasia on core biopsy and subsequent radical prostatectomy: An in depth case report of a rare variant

Human Pathology: Case Reports, 2017
A 69-year-old man underwent a robotic-assisted laparoscopic prostatectomy after a biopsy proven diagnosis of prostatic adenocarcinoma (PCa). Both the biopsy and the prostatectomy specimens revealed an organ-confined conventional PCa of Gleason score 3 ...
Paul Friedman, MD, Daniel Costa, MD, Payal Kapur, MD   +2 more
doaj   +1 more source

Friend or foe? The current epidemiologic evidence on selenium and human cancer risk. [PDF]

, 2013
Scientific opinion on the relationship between selenium and the risk of cancer has undergone radical change over the years, with selenium first viewed as a possible carcinogen in the 1940s then as a possible cancer preventive agent in the 1960s-2000s ...
Ammar E M, Bhattacharya A, Bjelakovic G, Blot W J, Buntzel J, CARLOTTA MALAGOLI, CATHERINE M. CRESPI, CINZIA DEL GIOVANE, Clayton C C, Cortes-Jofre M, Csallany A S, Dalkin B W, Dennert G, Dreno B, Duffield-Lillico A J, Hafeman D G, Hartman T J, Hercberg S, Hunter D J, Karp D D, Kim Y W, Kok F J, Krogh V, Levander OA., Li H, Li W, Lillico A, MARCO VINCETI, Marshall J R, Nelson A A, Ovaskainen M L, Peleg I, Ravn-Haren G, Rees K, Reid M E, Rothman K J, Salbe A D, Salbe A D, Salonen J T, Shamberger R J, Sunde RA., Swanson C A, Trougakos IP., van den Brandt P A, Vinceti M, Vinceti M, VITTORIO KROGH, Zheng S, Zhuo H   +48 more
core   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Histopathologic Review of Previously Negative Prostatic Core Needle Biopsies following a New Diagnosis of Adenocarcinoma of the Prostate by Core Needle Biopsies: Implications for Quality Assurance Programs

Clinical Medicine Insights: Pathology, 2008
Programs for quality assurance are increasingly important in surgical pathology. Many quality assurance (QA) techniques for surgical pathology were adopted from procedures introduced in cytopathology.
Jay Patel, Lester J. Layfield M.D.
doaj   +1 more source

Association between tumor-associated macrophages and microvessel density on prostate cancer progression

Prostate International, 2015
Background: To evaluate tumor-associated macrophages (TAMs) infiltration and microvessel density as possible prognostic factors related to prostate cancer (PCa) progression. Methods: Immunostaining of TAMs in prostate biopsy specimens was performed using
Prahara Yuri, Ahmad Zulfan Hendri, Raden Danarto   +2 more
doaj   +1 more source