Results 261 to 270 of about 834,651 (394)

F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway

open access: yesAdvanced Science, EarlyView.
In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu   +16 more
wiley   +1 more source

Programmable Pentamolecular Cross‐Scale Imaging Reveals the Multiplicative Synergistic Effect of High‐Fat / High‐Salt Diet on Atherosclerosis

open access: yesAdvanced Science, EarlyView.
This study demonstrates multifactorial lifestyle impacts on the pathogenesis and progression of cardiovascular diseases by a nanofluorescence sensor array for detecting four redox species and protein phosphorylation levels. Through cross‐scale fluorescence imaging of rats with different diets, we revealed that compared with single dietary interventions,
Jin Li   +9 more
wiley   +1 more source

Mitigation of Metabolic Diseases Through Personalized Nutrition: A Critical In-Depth Review. [PDF]

open access: yesFood Sci Nutr
Arshad MT   +7 more
europepmc   +1 more source

Effects of dietary tea catechins on alpha-tocopherol levels, lipid peroxidation, and erythrocyte deformability in rats fed on high palm oil and perilla oil diets.

open access: yesBiological and Pharmaceutical Bulletin, 1993
F. Nanjo   +6 more
semanticscholar   +1 more source

Targeted Mitochondrial ECSIT Overexpression Attenuates MASH by Increasing OTUD3 Expression

open access: yesAdvanced Science, EarlyView.
Mitochondrial ECSIT expression is reduced during MASH pathogenesis. Overexpression of mitochondrial ECSIT mitigates steatohepatitis and maintains hepatic metabolic homeostasis. Mechanistically, ECSIT enhances intramitochondrial OTUD3 expression to stabilize SIRT3 through deubiquitination, thus preserving mitochondrial function and impeding disease ...
Yuqing Jiang   +11 more
wiley   +1 more source

Effects of two high-fat diets with different fatty acid compositions on glucose and lipid metabolism in healthy young women.

open access: yesAmerican Journal of Clinical Nutrition, 1994
M. Uusitupa   +7 more
semanticscholar   +1 more source

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