Severe consequences of a high-lipid diet include hydrogen sulfide dysfunction and enhanced aggression in glioblastoma [PDF]
Journal of Clinical Investigation, 2021 Glioblastoma (GBM) remains among the deadliest of human malignancies, and the emergence of the cancer stem cell (CSC) phenotype represents a major challenge to durable treatment response. Because the environmental and lifestyle factors that impact CSC populations are not clear, we sought to understand the consequences of diet on CSC enrichment.
Daniel J. Silver +10 more
openaire +2 more sources
New Marker of Colon Cancer Risk Associated with Heme Intake: 1,4-Dihydroxynonane Mercapturic Acid [PDF]
, 2006 Background: Red meat consumption is associated with an increased risk of colon cancer. Animal studies show that heme, found in red meat, promotes preneoplastic lesions in the colon, probably due to the oxidative properties of this compound.
Bingham, Sheila A. +8 more
core +4 more sources
Journal of Lipid Research, 1991 To assess whether lipid peroxidation of hepatic mitochondria is associated with cholestatic hepatic injury we examined the effect of bile duct ligation (BDL) versus sham surgery on mitochondrial lipids of rats maintained on one of seven diets.
RJ Sokol, M Devereaux, RA Khandwala
doaj +1 more source
Metabolomic analysis of simvastatin and fenofibrate intervention in high-lipid diet-induced hyperlipidemia rats [PDF]
Acta Pharmacologica Sinica, 2014 To investigate the metabolite changes caused by simvastatin or fenofibrate intervention in diet-induced hyperlipidemia rats using a GC-MS-based metabolomic profiling approach.SD rats were fed with high-lipid diet for 4 weeks to induce hyperlipidemia, then the rats were fed with normal diet, and orally administered with simvastatin (10 mg·kg(-1)·d(-1 ...
Qiu-yu, Xu +9 more
openaire +2 more sources
Meat and cancer: haemoglobin and haemin in a low calcium diet promote colorectal carcinogenesis at the aberrant crypt stage in rats [PDF]
, 2003 High intake of red meat, but not of white meat, is associated with an increased risk of colon cancer. However, red meat does not promote cancer in rodents.
Corpet, Denis E. +4 more
core +5 more sources
Apc mutation induces resistance of colonic cells to lipoperoxide-triggered apoptosis induced by faecal water from haem-fed rats [PDF]
, 2006 Recent epidemiological studies suggest that high meat intake is associated with promotion of colon cancer linked to haem-iron intake. We previously reported that dietary haem, in the form of either haemoglobin or meat, promotes precancerous lesions in ...
Guéraud, Françoise +5 more
core +1 more source
Soluble Fermentable Dietary Fibre (Pectin) Decreases Caloric Intake, Adiposity and Lipidaemia in High-Fat Diet-Induced Obese Rats [PDF]
, 2015 Funding: This work was funded by the Scottish Government Rural and Environment Science and Analytical Services Division. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer ...
Adam, Clare L +3 more
core +7 more sources
HIGH LIPID DIET MODEL AND THE EXPRESSION OF INTERLEUKIN-4
Trakia Journal of Sciences, 2019 PURPOSE: The aim of the present study was to demonstrate the expression of inflammatory marker -IL-4 in visceral adipose tissue, testis, and blood serum when experimentally presented for obesity in rats. METHODS: We used a high-lipid diet model leading to the development of obesity in rats. 50 male Wistar rats were used.
M. Pencheva, Y. Koeva, I. Dimitrov
openaire +1 more source
Mouse apolipoprotein A-IV gene: nucleotide sequence and induction by a high-lipid diet. [PDF]
Molecular and Cellular Biology, 1986 Apolipoprotein A-IV (apo A-IV) functions in conjunction with other apolipoproteins to form lipoprotein particles which are involved in lipid homeostasis. In this report we present the nucleotide sequence of the mouse apo A-IV gene and demonstrate its induction in the liver by chronically high dietary lipid. The apo A-IV gene consists of three exons and
S C, Williams +4 more
openaire +2 more sources
Effects of High Dietary Carbohydrate and Lipid Intake on the Lifespan of C. elegans
Cells, 2021 Health and lifespan are influenced by dietary nutrients, whose balance is dependent on the supply or demand of each organism. Many studies have shown that an increased carbohydrate–lipid intake plays a critical role in metabolic dysregulation, which ...
Berenice Franco-Juárez +6 more
semanticscholar +1 more source