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Mass spectrometry imaging with high resolution in mass and space [PDF]

Histochemistry and Cell Biology, 2013
Mass spectrometry (MS) imaging links molecular information and the spatial distribution of analytes within a sample. In contrast to most histochemical techniques, mass spectrometry imaging can differentiate molecular modifications and does not require labeling of targeted compounds. We have recently introduced the first mass spectrometry imaging method
Andreas Roempp, Bernhard Spengler
exaly   +3 more sources

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High-resolution mass spectrometry for glycoproteomics

Bioanalysis, 2023
Tweetable abstract Bottom-up glycoproteomics combined with top-down strategy allows direct analysis of glycoform-mapped glycosylation and its glycans by high-resolution mass spectrometry.
Siyue Bo, Rumeng Zhang, Lingbo Zhao, Shuang Yang, Zhaohui Lu, Perry G Wang   +5 more
openaire   +2 more sources

Boundaries of Mass Resolution in Native Mass Spectrometry

Journal of the American Society for Mass Spectrometry, 2014
Over the last two decades, native mass spectrometry (MS) has emerged as a valuable tool to study intact proteins and noncovalent protein complexes. Studied experimental systems range from small-molecule (drug)-protein interactions, to nanomachineries ...
Philip Lössl, Albert Heck, Joost Snijder   +2 more
exaly   +1 more source

Mass microscopy: high-resolution imaging mass spectrometry

Journal of Electron Microscopy, 2010
Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is a technique that localizes the spatial distribution of molecules and identifies structures by their molecular mass signatures. Recently, the resolution of MALDI-IMS has been up to microscopic level. MALDI-IMS does not need either separation or purification procedures
Mitsutoshi, Setou, Nobuya, Kurabe
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High resolution field desorption mass spectrometry

Analytica Chimica Acta, 1976
Abstract Sulphate esters and sulphate salts of biochemicals and pharmacologically active compounds have been investigated by field desorption mass spectrometry. The underivatized substances gave high cation and cluster ion intensities. Low, but structurally significant, fragmentation was observed.
H.-R. Schulten, W.D. Lehmann
openaire   +1 more source

High resolution mass spectrometry. Bufadienolides—II.

Organic Mass Spectrometry, 1972
AbstractComplete low resolution mass spectra and high resolution data for selected important peaks are presented and discussed for a series of naturally occurring 14β, 15β‐epoxybufadienolides (toad poisons) and their derivatives. The compounds examined were resibufogenin, marinobufagin, cinobufagin, desacetylcinobufagin, cinobufotalin ...
Peter Brown, Yoshiaki Kamano, George R. Pettit   +2 more
openaire   +1 more source

HIGH-RESOLUTION MASS SPECTROMETRY

1971
Mass Spectrometry is unique in the type and amount of information that it can often supply on submicrogram samples. Recent advances include improved understanding of the basic factors affecting ion reaction rates, and application of these in metastable and collision-induced decompositions.
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Subtyping of the Influenza Virus by High Resolution Mass Spectrometry

Analytical Chemistry, 2009
High resolution, high mass accuracy mass spectra of hemagglutinin and whole virus digests of influenza are shown to be able to be used to type and subtype the major circulating forms of the virus in humans. Conserved residues and peptide segments of the hemagglutinin antigen have been identified across type A and B strains, and for type B strains of ...
Downard, Kevin M., Wong, Jason W H, Schwahn, Alexander B.   +2 more
openaire   +4 more sources

High-Resolution Liquid Chromatography–Mass Spectrometry for Lipidomics

2023
Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) is a powerful tool for identification and classification of lipids. Ultra-high performance liquid chromatography (UHPLC) allows for robust separations of complex mixtures, while high-resolution mass spectrometry (HRMS) identifies compounds with efficiency and accuracy (Zullig T and ...
Faith Christine, Harvey, Vanessa, Collao, Sanjoy K, Bhattacharya   +2 more
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Mass Spectrometry and High Resolution Mass Spectrometry: An Overview

2017
In this chapter, a brief overview of fundamentals in mass spectrometry and some applications are presented. The main concepts in ionization techniques, classical techniques and ambient mass spectrometry are followed by an overview on analyzers.
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