Results 61 to 70 of about 376,836 (309)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

High-resolution acoustic ejection mass spectrometry for high-throughput library screening

SLAS Technology
An approach is described for high-throughput quality assessment of drug candidate libraries using high-resolution acoustic ejection mass spectrometry (AEMS).
Nate Hoxie, David R. Calabrese, Zina Itkin, Glenn Gomba, Min Shen, Meghav Verma, John S. Janiszewski, Jonathan H. Shrimp, Kelli M. Wilson, Sam Michael, Matthew D. Hall, Lyle Burton, Tom Covey, Chang Liu   +13 more
doaj   +1 more source

Mapping an atlas of tissue-specific Drosophila melanogaster metabolomes by high resolution mass spectrometry. [PDF]

PLoS ONE, 2013
Metabolomics can provide exciting insights into organismal function, but most work on simple models has focussed on the whole organism metabolome, so missing the contributions of individual tissues.
Venkateswara R Chintapalli, Mohammed Al Bratty, Dominika Korzekwa, David G Watson, Julian A T Dow   +4 more
doaj   +1 more source

Non-targeted screening of emerging contaminants in drinking water based on high-resolution mass spectrometry

Shanghai yufang yixue, 2023
ObjectiveTo establish a non-targeted screening method for emerging contaminants in drinking water based on high-resolution mass spectrometry and apply it to actual water samples.MethodsA total of 9 drinking water samples collected from 3 reservoirs in ...
WU Linying, FENG Chao, WANG Guoquan, XUAN Dongliang, JIN Yu’e, PENG Qian, LU Dasheng   +6 more
doaj   +1 more source

Liquid chromatography-tandem mass spectrometry - Application in the clinical laboratory [PDF]

, 2003
This review provides a concise survey of liquid chromatography tandem mass spectrometry (LCTMS) as an emerging technology in clinical chemistry. The combination of two mass spectrometers with an interposed collision cell characterizes LCTMS as an ...
Michael Vogeser, Vogeser, Michael
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

High-resolution mass spectrometry for detecting Acetylcholine in Arabidopsis [PDF]

Plant Signaling & Behavior, 2015
Acetylcholine (ACh) was first identified a century ago, and has long been known as a neurotransmitter in animals. However, it has been shown recently that the occurrence of ACh is widespread among various non-animal species including higher plants. Although previous reports suggest that various plant species are capable of responding to exogenously ...
Jun, Murata, Takehiro, Watanabe, Kohtaro, Sugahara, Tohru, Yamagaki, Toshio, Takahashi   +4 more
openaire   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Determination of Synthetic Cathinones in Urine and Oral Fluid by Liquid Chromatography High-Resolution Mass Spectrometry and Low-Resolution Mass Spectrometry: A Method Comparison

Separations, 2020
Synthetic cathinones have become very popular recreational drugs. Therefore, determining them in biological samples is now a matter of concern. In recent years, different methods that have been developed can determine these drugs at low-concentration ...
Sergi Pascual-Caro, Francesc Borrull, Carme Aguilar, Marta Calull   +3 more
doaj   +1 more source

Innovative solutions for enhanced illicit drugs profiling using comprehensive two-dimensional gas chromatography and mass spectrometry technologies [PDF]

, 2014
This project aimed to determine whether comprehensive two-dimensional gas chromatography is suitable for routine use in a forensic laboratory for profiling illicit substances.
Philip Marriot, Blagoj Mitrevski
core