Results 41 to 50 of about 1,154,439 (299)
High-throughput detection of metal contamination in HTS outputs
SLAS Discovery, 2022 Large compound libraries utilised for HTS often include metal contaminated compounds which can interfere with assay signal or target biology, and therefore appear as hits.
Corinne Molyneux +5 more
doaj +1 more source
High-Throughput Sequencing Technologies [PDF]
Molecular Cell, 2015 The human genome sequence has profoundly altered our understanding of biology, human diversity, and disease. The path from the first draft sequence to our nascent era of personal genomes and genomic medicine has been made possible only because of the extraordinary advancements in DNA sequencing technologies over the past 10 years.
Reuter, Jason A. +2 more
openaire +2 more sources
High throughput biodegradation-screening test to prioritize and evaluate chemical biodegradability [PDF]
, 2017 Comprehensive assessment of environmental biodegradability of pollutants is limited by the use of low throughput systems. These are epitomized by the Organisation for Economic Cooperation and Development (OECD) Ready Biodegradability Tests (RBTs), where ...
Martin, Timothy J. +5 more
core +2 more sources
Measuring reproducibility of high-throughput experiments
, 2011 Reproducibility is essential to reliable scientific discovery in high-throughput experiments. In this work we propose a unified approach to measure the reproducibility of findings identified from replicate experiments and identify putative discoveries ...
Bickel, Peter J. +3 more
core +1 more source
Protein synthesis rate is the predominant regulator of protein expression during differentiation
Molecular Systems Biology, 2013 External perturbations, by forcing cells to adapt to a new environment, often elicit large‐scale changes in gene expression resulting in an altered proteome that improves the cell's fitness in the new conditions.
Anders R Kristensen +2 more
doaj +1 more source
Novel Antiretroviral Structures from Marine Organisms
Molecules, 2019 In spite of significant advancements and success in antiretroviral therapies directed against HIV infection, there is no cure for HIV, which scan persist in a human body in its latent form and become reactivated under favorable conditions.
Karlo Wittine +3 more
doaj +1 more source
Stem Cells International, 2016 Current approaches in human embryonic stem cell (hESC) to pancreatic beta cell differentiation have largely been based on knowledge gained from developmental studies of the epithelial pancreas, while the potential roles of other supporting tissue ...
Holger A. Russ +8 more
doaj +1 more source
High-throughput chromatin accessibility profiling at single-cell resolution. [PDF]
, 2018 Here we develop a high-throughput single-cell ATAC-seq (assay for transposition of accessible chromatin) method to measure physical access to DNA in whole cells.
Bostick, Magnolia +9 more
core +3 more sources
Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM
FEBS Letters, EarlyView.Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley +1 more source
Polyphenol-Based Design of Functional Olive Leaf Infusions
Food Technology and Biotechnology, 2019 The beneficial properties of polyphenols are widely recognized, and polyphenol-rich olive oil, which is part of the typical Mediterranean diet, has been identified as having positive health effects.
Željka Peršurić +3 more
doaj +1 more source