Results 11 to 20 of about 1,415 (165)

Optimization of conditions for in vitro modeling of subgingival normobiosis and dysbiosis

Frontiers in Microbiology, 2022
Modeling subgingival microbiome in health and disease is key to identifying the drivers of dysbiosis and to studying microbiome modulation. Here, we optimize growth conditions of our previously described in vitro subgingival microbiome model. Subgingival
Divyashri Baraniya, Thuy Do, Tsute Chen, Jasim M. Albandar, Susan M. Chialastri, Deirdre A. Devine, Philip D. Marsh, Nezar N. Al-Hebshi   +7 more
doaj   +1 more source

Search for Novel Mutational Targets in Human Endocrine Diseases [PDF]

Endocrinology and Metabolism, 2019
The identification of disease-causing genetic variations is an important goal in the field of genetics. Advancements in genetic technology have changed scientific knowledge and made it possible to determine the basic mechanism and pathogenesis of human ...
So Young Park, Myeong Han Seo, Sihoon Lee   +2 more
doaj   +1 more source

Correcting nucleotide-specific biases in high-throughput sequencing data

BMC Bioinformatics, 2017
Background High-throughput sequence (HTS) data exhibit position-specific nucleotide biases that obscure the intended signal and reduce the effectiveness of these data for downstream analyses.
Jeremy R. Wang, Bryan Quach, Terrence S. Furey   +2 more
doaj   +1 more source

Cordblood-Based High-Throughput Screening for Deafness Gene of 646 Newborns in Jinan Area of China [PDF]

Clinical and Experimental Otorhinolaryngology, 2015
ObjectivesInfants with slight/mild or late-onset hearing impairment might be missed in universal newborn hearing screening (UNHS). We identified the mutation hot spot of common deaf gene in the newborns in Jinan area population by screening the mutation ...
Shou-Xia Li, Ding-Li Chen, Su-Bin Zhao, Li-Li Guo, Hai-Qin Feng, Xiao-Fang Zhang, Li-Li Ping, Zhi-Ming Yang, Cai-Xia Sun, Gen-Dong Yao   +9 more
doaj   +1 more source

Single-nucleotide polymorphism discovery by high-throughput sequencing in sorghum

BMC Genomics, 2011
Background Eight diverse sorghum (Sorghum bicolor L. Moench) accessions were subjected to short-read genome sequencing to characterize the distribution of single-nucleotide polymorphisms (SNPs).
White Frank F, Antony Ginny, Li Xianran, Wu Yuye, Wang Shichen, Nelson James C, Yu Jianming   +6 more
doaj   +1 more source

Bacteriome analysis of Aggregatibacter actinomycetemcomitans-JP2 genotype-associated Grade C periodontitis in Moroccan adolescents

Frontiers in Oral Health, 2023
BackgroundGrade C (previously aggressive) periodontitis (GCP) in adolescents is prevalent in certain parts of Africa where it is associated with JP2 genotype, a highly virulent strain of Aggregatibacter actinomycetemcomitans. The aim of this study was to
Vijaya Lakshmi Pavani Molli, Jamila Kissa, Divyashri Baraniya, Amina Gharibi, Tsute Chen, Nezar N. Al-Hebshi, Jasim M. Albandar   +6 more
doaj   +1 more source

Evaluation of the diagnostic effectiveness of next generation sequencing in sepsis etiology: a systematic review and meta-analysis

Journal of Infection in Developing Countries, 2023
Introduction: Systematic evaluation of the diagnostic value of next generation sequencing (NGS) in sepsis etiology. Methodology: We conducted a systematic search on four databases (Web of Science, Cochrane, PubMed, and Embase) and compiled diagnostic ...
Dong Li, Yinghao Yang, Ying Xie, Jianrong Wang, Wensheng Xu, Junxue Wang, Xiaofeng Hang   +6 more
doaj   +1 more source

Diagnostics of hereditary cancer syndromes by ngs. A database creation experience [PDF]

Клиническая практика, 2021
Background: More than 500 thousand new cases of malignant neoplasms are registered annually in the Russian Federation, of which more than 50 thousand new cases are due to hereditary forms.
Ivan S. Abramov, Tatyana S. Lisitsa, Anna M. Stroganova, Oxana O. Ryabaya, Anastasiya M. Danishevich, Anastasia O. Khakhina, Anastasiya I. Zakamornaya, Alina D. Matsvay, German A. Shipulin   +8 more
doaj   +1 more source

Genes Associated with Coma or Recurrent Coma and Role of Next Generation Sequencing in Diagnosis of Disease-Causing Genes

Medical Laboratory Journal, 2022
Coma is a state of prolonged unconsciousness. Some coma cases result from inherited disorders such as fatty-acid β-oxidation disorder, acute intermittent porphyria (due to mutations in genes CPT I, CPTII and ACADM), urea cycle defects (due to mutation in
fatemeh asadi, hamedreza goodarzi, javad zahiri, mojtaba jafarinia   +3 more
doaj  

Clinical features of Streptococcus intermedius infection in children: a case series study

Frontiers in Microbiology, 2023
IntroductionStreptococcus intermedius is an opportunistic pathogen associated with prolonged hospital stays and high mortality rates in adults. However, little is currently known about the clinical features of Streptococcus intermedius infection in ...
Zhufei Xu, Lichao Gao, Dan Xu, Dehua Yang, Zhimin Chen, Yingshuo Wang   +5 more
doaj   +1 more source