Results 11 to 20 of about 15,621,385 (284)

Correcting nucleotide-specific biases in high-throughput sequencing data [PDF]

BMC Bioinformatics, 2017
Background High-throughput sequence (HTS) data exhibit position-specific nucleotide biases that obscure the intended signal and reduce the effectiveness of these data for downstream analyses.
Jeremy R. Wang, Bryan Quach, Terrence S. Furey   +2 more
doaj   +3 more sources

Single-nucleotide polymorphism discovery by high-throughput sequencing in sorghum [PDF]

BMC Genomics, 2011
Background Eight diverse sorghum (Sorghum bicolor L. Moench) accessions were subjected to short-read genome sequencing to characterize the distribution of single-nucleotide polymorphisms (SNPs).
White Frank F, Antony Ginny, Li Xianran, Wu Yuye, Wang Shichen, Nelson James C, Yu Jianming   +6 more
doaj   +3 more sources

High-throughput sequencing reveals single nucleotide variants in longer-kernel bread wheat [PDF]

Frontiers in Plant Science, 2016
The transcriptomes of bread wheat Yunong 201 and its ethyl methanesulfonate (EMS) derivative Yunong 3114 were obtained by next-sequencing technology. Single nucleotide variants (SNVs) in the wheat strains were explored and compared.
Feng Chen, Zibo Zhu, Xiaobian Zhou, Yan Yan, Zhongdong Dong, Dangqun Cui   +5 more
doaj   +3 more sources

High-throughput telomere length measurement at nucleotide resolution using the PacBio high fidelity sequencing platform [PDF]

Nature Communications, 2023
There exist challenges in quantifying the length of individual telomeres at single nucleotide resolution. Here the authors report a method to capture telomeres and accurately analyse their length in human cell lines and patient peripheral blood leukocyte
Cheng-Yong Tham, LaiFong Poon, TingDong Yan, Javier Yu Peng Koh, Muhammad Khairul Ramlee, Vania Swee Imm Teoh, Suihan Zhang, Yi Cai, Zebin Hong, Gina S. Lee, Jin Liu, Hai Wei Song, William Ying Khee Hwang, Bin Tean Teh, Patrick Tan, Lifeng Xu, Angela S. Koh, Motomi Osato, Shang Li   +18 more
doaj   +4 more sources

Large scale single nucleotide polymorphism discovery in unsequenced genomes using second generation high throughput sequencing technology: applied to turkey [PDF]

BMC Genomics, 2009
Background The development of second generation sequencing methods has enabled large scale DNA variation studies at moderate cost. For the high throughput discovery of single nucleotide polymorphisms (SNPs) in species lacking a sequenced reference genome,
Kerstens Hindrik HD, Veenendaal, A., Johan T den Dunnen, Martien AM Groenen, Bert W Dibbits, Thomas FC Chin-A-Woeng, Dunnen, J.T., den, Groenen, M.A.M., Dibbits, B.W., Kerstens, H.H.D., Chin-A-Woeng, T.F.C., Dibbits Bert W, Hindrik HD Kerstens, Richard PMA Crooijmans, Veenendaal Albertine, den Dunnen Johan T, Chin-A-Woeng Thomas FC, Crooijmans, R.P.M.A., Albertine Veenendaal, Groenen Martien AM, Crooijmans Richard PMA, den Dunnen, J.T.   +21 more
core   +6 more sources

Gene expression profile of Scardovia spp. in the metatranscriptome of root caries [PDF]

Brazilian Oral Research, 2020
A few investigations of caries biofilms have identified Scardovia spp.; however, little is known about its involvement in caries pathogenesis. The purpose of this study was to assess the gene expression profile of Scardovia spp.
Naile DAMÉ-TEIXEIRA, Clarissa Cavalcanti Fatturi PAROLO, Marisa MALZ, Deirdre Ann DEVINE, Thuy DO   +4 more
doaj   +2 more sources

Analytical Tools and Databases for Metagenomics in the Next-Generation Sequencing Era [PDF]

Genomics & Informatics, 2013
Metagenomics has become one of the indispensable tools in microbial ecology for the last few decades, and a new revolution in metagenomic studies is now about to begin, with the help of recent advances of sequencing techniques.
Mincheol Kim, Ki-Hyun Lee, Seok-Whan Yoon, Bong-Soo Kim, Jongsik Chun, Hana Yi   +5 more
doaj   +1 more source

Uncommon nucleotide excision repair phenotypes revealed by targeted high-throughput sequencing [PDF]

Orphanet Journal of Rare Diseases, 2016
Deficient nucleotide excision repair (NER) activity causes a variety of autosomal recessive diseases including xeroderma pigmentosum (XP) a disorder which pre-disposes to skin cancer, and the severe multisystem condition known as Cockayne syndrome (CS).
Calmels, Nadège, Greff, Géraldine, Obringer, Cathy, Kempf, Nadine, Gasnier, Claire, Tarabeux, Julien, Miguet, Marguerite, Baujat, Geneviève, Bessis, Didier, Bretones, Patricia, Cavau, Anne, Digeon, Béatrice, Doco-Fenzy, Martine, Doray, Bérénice, Feillet, François, Gardeazabal, Jesus, Gener, Blanca, Julia, Sophie, Llano-Rivas, Isabel, Mazur, Artur, Michot, Caroline, Renaldo-Robin, Florence, Rossi, Massimiliano, Sabouraud, Pascal, Keren, Boris, Depienne, Christel, Muller, Jean, Mandel, Jean-Louis, Laugel, Vincent   +28 more
openaire   +4 more sources

Optimization of conditions for in vitro modeling of subgingival normobiosis and dysbiosis

Frontiers in Microbiology, 2022
Modeling subgingival microbiome in health and disease is key to identifying the drivers of dysbiosis and to studying microbiome modulation. Here, we optimize growth conditions of our previously described in vitro subgingival microbiome model. Subgingival
Divyashri Baraniya, Thuy Do, Tsute Chen, Jasim M. Albandar, Susan M. Chialastri, Deirdre A. Devine, Philip D. Marsh, Nezar N. Al-Hebshi   +7 more
doaj   +1 more source

Search for Novel Mutational Targets in Human Endocrine Diseases [PDF]

Endocrinology and Metabolism, 2019
The identification of disease-causing genetic variations is an important goal in the field of genetics. Advancements in genetic technology have changed scientific knowledge and made it possible to determine the basic mechanism and pathogenesis of human ...
So Young Park, Myeong Han Seo, Sihoon Lee   +2 more
doaj   +1 more source