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High throughput screening on a low budget [PDF]

Nature Biotechnology, 1996
New assay technologies have combined with advances in automation, miniaturization, and affordable computing power to put small molecule drug discovery within reach of biotechnology ...
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Network Medicine and High Throughput Screening

Current Drug Discovery Technologies, 2013
A new paradigm is emerging in modern drug discovery. It is a fusion of traditional and modern medicine, phenotypic and targeted drug discovery, or systems and reductionist thinking. This is exemplified by using a combination of network medicine and high throughput screening. It blends the use of physiologically relevant biological systems with the high
Robert E. Smith, Ralph H. Vocque, Kevin Tran   +2 more
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High-Throughput Screening

2014
Ion channels are a class of proteins that are attractive human, animal, and crop health targets. Ion channels can be considered high-gain (physiologically speaking), high-reward (therapeutic benefit) and high technology (difficult assay development) drug targets.
Sabine Schaertl, Alexander Böcker, Stephen D. Hess   +2 more
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High-throughput screening technologies

2003
In the past 5 years the world of high-throughput screening (HTS), which targets lead discovery for both pharmaceutical and agrochemical applications, is in a highly rapid developmental stage. Today, restructuring the drug discovery programs to develop highest performance is a key issue of pharmaceutical companies.
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High-throughput screening brings in the crops

Drug Discovery Today, 2000
Screening is the acknowledgement of ignorance. Such a provocative statement might not amuse our community and, in fact, an incredible quantity of knowledge does go into each screen. However, from a structural point of view, screening is where serendipity meets prediction.
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Practical high throughput screening

1997
During the first half of the century, there was virtually an exclusive reliance on animal testing as the primary model for drug discovery and development. New chemical entities were administered to rodents in the primary screen assay, and the appropriate responses were monitored for indications of therapeutic potential.
Alex Harris, Melvin Reichman
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High Throughput Screening of Allergy

2015
Allergen avoidance and specific immunotherapy that are based on an accurate diagnosis of allergy have proven to be helpful for the prevention and treatment of allergic diseases. Detection of specific IgE against different allergens in serum or plasma can be used as an important criterion for allergy diagnosis.
Ailin Tao, Junyan Zhang
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Whither high-throughput screening?

Drug Discovery Today, 2000
Abstract ‘…today’s HTS will become the fulcrum that fully leverages genomics in drug discovery’
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Overview on High‐Throughput Screening

Current Protocols in Pharmacology, 2003
AbstractThe known effects of drugs from a variety of pharmacological/therapeutic classes on the respiratory system, the life‐threatening consequences of respiratory dysfunction, and world‐wide regulatory safety guidelines all support the need for conducting respiratory evaluations in safety pharmacology. This unit provides an overview of the functional
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New technologies for high-throughput screening

Current Opinion in Chemical Biology, 1997
To screen efficiently the millions of compounds that are synthesized using combinatorial and automated methods, dramatically improved assay technologies are currently needed. In 96-well microtiter plates, nonradioactive techniques (primarily fluorimetric) and cell-based functional methods have moved to the cutting edge, while clever assays that extract
Jonathan J. Burbaum, Nolan H. Sigal
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