Results 111 to 120 of about 1,236,846 (314)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

A novel cost effective and high-throughput isolation and identification method for marine microalgae [PDF]

, 2014
Background: Marine microalgae are of major ecologic and emerging economic importance. Biotechnological screening schemes of microalgae for specific traits and laboratory experiments to advance our knowledge on algal biology and evolution strongly benefit
Jahn, Martin T, Mock, Thomas, Schmidt, Katrin   +2 more
core   +2 more sources

A comprehensive review of Schisandrin B’s preclinical antitumor activity and mechanistic insights from network pharmacology

Frontiers in Pharmacology
As an active constituent in the extract of dried fruits of Schisandra chinensis, Schisandrin B exhibits diverse pharmacological effects, including liver protection, anti-inflammatory and anti-oxidant. Numerous studies have demonstrated that Schisandrin B
Yanhua Fang, Yanhua Fang, Juan Pan, Piao Wang, Piao Wang, Ruoyu Wang, Shanshan Liang   +6 more
doaj   +1 more source

Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides

Nature Communications, 2019
Nematodes causing lymphatic filariasis and onchocerciasis rely on their bacterial endosymbiont, Wolbachia, for survival and fecundity, making Wolbachia a promising therapeutic target.
R. Clare, C. Bardelle, Paul Harper, W. D. Hong, U. Börjesson, K. Johnston, M. Collier, Laura J. Myhill, A. Cassidy, D. Plant, Helen Plant, R. Clark, Darren Cook, A. Steven, J. Archer, P. McGillan, S. Charoensutthivarakul, Jaclyn Bibby, Raman Sharma, G. Nixon, B. Slatko, L. Cantin, Bo Wu, J. Turner, L. Ford, Kirsty Rich, M. Wigglesworth, Neil G. Berry, O. PaulM., Neill, M. Taylor, S. A. Ward   +31 more
semanticscholar   +1 more source

Current status and future directions of high-throughput ADME screening in drug discovery

Journal of Pharmaceutical Analysis, 2020
During the last decade high-throughput in vitro absorption, distribution, metabolism and excretion (HT-ADME) screening has become an essential part of any drug discovery effort of synthetic molecules.
W. Shou
semanticscholar   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

High throughput phenotyping methods for screening rice germplasm under water limited field conditions [PDF]

, 2010
A Cirad project (Orytage) involving NARS and IRC aims at developing an international phenotyping network for rice adaptations to drought and thermal stresses in the context of gene discovery and genetic mapping.
Audebert, Alain, Châtel, Marc, Grenier, Cécile, Ospina, Yolima, Rodriguez, Francisco   +4 more
core  

CRISPR–Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome

Nature Biotechnology, 2017
Large genome-mapping consortia and thousands of genome-wide association studies have identified non-protein-coding elements in the genome as having a central role in various biological processes.
Tyler S. Klann, Joshua B. Black, Malathi K Chellappan, Alexias Safi, Lingyun Song, Isaac B. Hilton, G. Crawford, Timothy E. Reddy, C. Gersbach   +8 more
semanticscholar   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Automating functional enzyme screening & characterization [PDF]

, 2018
This work has been presented in the 10th IWBDA workshop.Microfluidics continue to gain traction as an inexpensive alternative to standard multi-well plate-based, and flow cytometry- based, assay platforms.
Densmore, Douglas, Lashkaripour, Ali, Ortiz, Luis   +2 more
core