Results 131 to 140 of about 16,617,738 (336)

The identification of bioactive natural products by High Throughput Screening (HTS)

, 2020
This chapter outlines the processes involved in the screening of natural product (NP) extracts for biological activity. The topics covered include biological diversity, the collection of biota samples, the preparation of NP extracts for screening, high ...
Jenkins, ID, Avery, VM, Camp, D, Carroll, AR, Quinn, RJ   +4 more
core   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Models for calcific aortic valve disease in vivo and in vitro

Cell Regeneration
Calcific Aortic Valve Disease (CAVD) is prevalent among the elderly as the most common valvular heart disease. Currently, no pharmaceutical interventions can effectively reverse or prevent CAVD, making valve replacement the primary therapeutic recourse ...
Zijin Zhu, Zhirong Liu, Donghui Zhang, Li Li, Jianqiu Pei, Lin Cai   +5 more
doaj   +1 more source

High-throughput automation enhances kidney organoid differentiation from human pluripotent stem cells and enables multidimensional phenotypic screening

Cell Stem Cell, 2018
SUMMARY Organoids derived from human pluripotent stem cells are a potentially powerful tool for high-throughput screening (HTS), but the complexity of organoid cultures poses a significant challenge for miniaturization and automation.
Stefan M Czerniecki, N. Cruz, J. Harder, Rajasree Menon, James E. Annis, E. Otto, Ramila E. Gulieva, Laura Islas, Yong Kyun Kim, Linh M. Tran, T. Martins, Jeffrey W. Pippin, Hongxia Fu, M. Kretzler, S. Shankland, J. Himmelfarb, R. Moon, N. Paragas, Benjamin S. Freedman   +18 more
semanticscholar   +1 more source

The Complete Automation of Cell Culture: Improvements for High-Throughput and High-Content Screening

, 2011
Genomic approaches provide enormous amounts of raw data with regard to genetic variation, the diversity of RNA species, and protein complement.
Caminada, D., Rizzu, P., Bochdanovits, Z., Shushant Jain, Peter Heutink, Sondervan, D., Zoltan Bochdanovits, David Sondervan, Jain, S., Patrizia Rizzu, Heutink, P., Daniel Caminada   +11 more
core   +1 more source

High-throughput characterization of fluid properties to predict droplet ejection for three-dimensional inkjet printing formulations [PDF]

, 2019
Inkjet printing has been used as an Additive Manufacturing (AM) method to fabricate three-dimensional (3D) structures. However, a lack of materials suitable for inkjet printing poses one of the key challenges that impedes industry from fully adopting ...
Xuesheng Chen, Roberts, Clive J., Ricky Wildman, Morgan R. Alexander, Zuoxin Zhou, Irvine, Derek, Richard Hague, Chen, Xuesheng, Wildman, Ricky, Derek Irvine, Laura Ruiz Cantu, Hague, Richard, Alexander, Morgan R., Clive J. Roberts, Ruiz Cantu, Laura, Tuck, Christopher, Christopher Tuck, Zhou, Zuoxin   +17 more
core   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

High-Throughput Fragment Screening by Affinity LC-MS

, 2013
Fragment screening, an emerging approach for hit finding in drug discovery, has recently been proven effective by its first approved drug, vemurafenib, for cancer treatment.
Fex, Tomas,, Bergström, Maria,, Duong-Thi, Minh-Dao,, Ohlson, Sten,, Isaksson, Roland,   +4 more
core   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source