Results 11 to 20 of about 1,074,205 (395)
Optimal Assembly for High Throughput Shotgun Sequencing [PDF]
BMC Bioinformatics, 2013 We present a framework for the design of optimal assembly algorithms for shotgun sequencing under the criterion of complete reconstruction. We derive a lower bound on the read length and the coverage depth required for reconstruction in terms of the ...
Bresler, Guy +2 more
core +7 more sources
High‐throughput sequencing for biology and medicine
Molecular Systems Biology, 2013 Advances in genome sequencing have progressed at a rapid pace, with increased throughput accompanied by plunging costs. But these advances go far beyond faster and cheaper. High‐throughput sequencing technologies are now routinely being applied to a wide
Wendy Weijia Soon +2 more
doaj +3 more sources
Compression of structured high-throughput sequencing data. [PDF]
PLoS ONE, 2013 Large biological datasets are being produced at a rapid pace and create substantial storage challenges, particularly in the domain of high-throughput sequencing (HTS). Most approaches currently used to store HTS data are either unable to quickly adapt to
Fabien Campagne +4 more
doaj +7 more sources
High-throughput sequencing technologies. [PDF]
Molecular Cell, 2015 The human genome sequence has profoundly altered our understanding of biology, human diversity, and disease. The path from the first draft sequence to our nascent era of personal genomes and genomic medicine has been made possible only because of the extraordinary advancements in DNA sequencing technologies over the past 10 years.
Jason A. Reuter, D. Spacek, M. Snyder
semanticscholar +3 more sources
High-throughput Sequencing Technology and Its Application in Epigenetics Studies [PDF]
SHS Web of Conferences, 2023 DNA sequencing technology is one of the important tools in modern life science research, and with the development of science and technology, sequencing technology is constantly changing.
Wang Zexuan
doaj +1 more source
The Principles and Applications of High-Throughput Sequencing Technologies
Development & Reproduction, 2023 The advancement in high-throughput sequencing (HTS) technology has revolutionized the field of biology, including genomics, epigenomics, transcriptomics, and metagenomics.
Jun-Yeong Lee
semanticscholar +1 more source
High-throughput RNA isoform sequencing using programmed cDNA concatenation
Nature Biotechnology, 2023 Full-length RNA-sequencing methods using long-read technologies can capture complete transcript isoforms, but their throughput is limited. We introduce multiplexed arrays isoform sequencing (MAS-ISO-seq), a technique for programmably concatenating ...
Aziz M Al'Khafaji +18 more
semanticscholar +1 more source
High-throughput Phenotyping with Temporal Sequences [PDF]
Journal of the American Medical Informatics Association, 2019 ABSTRACTObjectiveHigh-throughput electronic phenotyping algorithms can accelerate translational research using data from electronic health record (EHR) systems. The temporal information buried in EHRs are often underutilized in developing computational phenotypic definitions.
Estiri, Hossein +5 more
openaire +3 more sources
Phigaro: high-throughput prophage sequence annotation [PDF]
Bioinformatics, 2020 Abstract Summary Phigaro is a standalone command-line application that is able to detect prophage regions taking raw genome and metagenome assemblies as an input. It also produces dynamic annotated ‘prophage genome maps’ and marks possible transposon insertion spots inside prophages.
Elizaveta V Starikova +6 more
openaire +3 more sources
Nature Communications, 2023 Long-read single-cell RNA isoform sequencing can elucidate the intricate landscape of alternative RNA splicing in individual cells, but it suffers from a low read throughput.
Zhuoxing Shi +11 more
semanticscholar +1 more source