Results 61 to 70 of about 15,885,779 (299)

Activation of notch signaling pathway is a potential mechanism for mucin2 reduction and intestinal mucosal barrier dysfunction in high-altitude hypoxia

Scientific Reports
High-altitude hypoxia can cause gastrointestinal issues and damage the intestinal mucosal barrier, which is crucial for digestion and nutrient absorption. The Notch signaling pathway affects this barrier’s integrity. This study explores the Notch pathway’
Ruhan Jia, Ying Han, Qinfang Zhu, Jingxuan Zhang, Huan Zhang, Maojia Ka, Yi Ma, Mohammed Gamah, Wei Zhang   +8 more
doaj   +1 more source

IL-10 Dysregulation in Acute Mountain Sickness Revealed by Transcriptome Analysis

Frontiers in Immunology, 2017
Acute mountain sickness (AMS), which may progress to life-threatening high-altitude cerebral edema, is a major threat to millions of people who live in or travel to high altitude.
Bao Liu, Bao Liu, Bao Liu, Jian Chen, Jian Chen, Jian Chen, Long Zhang, Yixing Gao, Yixing Gao, Yixing Gao, Jianhua Cui, Erlong Zhang, Erlong Zhang, Erlong Zhang, Gang Xu, Gang Xu, Gang Xu, Yan Liang, Yu Liang, Jian Wang, Yuqi Gao, Yuqi Gao, Yuqi Gao   +22 more
doaj   +1 more source

Memory impairment induced by exposure to simulated hypobaric hypoxia and phosphoproteomic analysis of hippocampus in mice

Di-san junyi daxue xuebao, 2022
Objective To observe the changes of protein phosphorylation levels in the hippocampus of mice with memory impairment caused by hypobaric hypoxia exposure, and to explore the key phosphorylated proteins and associated pathways involved in memory deficits.
DONG Huaping, ZHONG Zhifeng, LI Peng, HUANG Pei, TIAN Huaijun, XIE Jiaxin, ZHOU Simin   +6 more
doaj   +1 more source

Origami‐Inspired Morphing Fuselage for Agile Fixed‐Wing Flight

Advanced Robotics Research, EarlyView.
Conventional aircraft steer with rigid control surfaces. SoAR instead replaces the fuselage itself with a cable‐driven origami continuum body that bends in 3D and compresses on demand. Whole‐fuselage morphing steers fixed‐wing flight: achieving sharp, near‐zero‐radius turns and rapid braking without ailerons, rudder, or elevator, while the same ...
Abudula Aihaitijiang, Cagdas D. Onal
wiley   +1 more source

Design and conduct of 'Xtreme Alps' : a double-blind, randomised controlled study of the effects of dietary nitrate supplementation on acclimatisation to high altitude [PDF]

, 2013
The study of healthy human volunteers ascending to high altitude provides a robust model of the complex physiological interplay that emulates human adaptation to hypoxaemia in clinical conditions.
Meale, Paula M., Mythen, Monty, Mythen, Michael G., Cobb, Alexandra, Levett, Denny Z.H., Xtreme Alps Research Group, Grocott, Michael P.W., Gilbert-Kawai, Edward T., Feelisch, Martin, Cumpstey, Andrew, Martin, Daniel S., Fernandez, Bernadette O., Mitchell, Kay, Khosravi, Maryam   +13 more
core   +1 more source

China's Low‐Carbon Energy Transition Over the Past Two Decades: Experiences and Implications

Advanced Science, EarlyView.
China's low‐carbon energy transition features a brief decline and subsequent rebound in coal consumption, alongside the rapid expansion of renewable energy. This study develops a stage‐based analytical framework to explain this evolution from the perspectives of economic development, energy security, and environmental sustainability, revealing how ...
Yu Liu, Zhiyu Tian, Zhengxian Zhang, Xinbei Li   +3 more
wiley   +1 more source

Sexual dimorphism in morphological, physio-biochemical, and haematological characteristics of high-altitude Bactrian camels

Discover Animals
High-altitude Bactrian camels (double-hump) are in limited numbers and become a vulnerable species of high-altitude livestock biodiversity. These camels are an important livestock resource, contributing as an integral part of the animal husbandry-based ...
Sunil Kumar, Vijay K. Bharti, Dolker Lamo, Zarina Batool, Krishna Kumar, Thinley Chospal, Swati, Om Prakash Chaurasia   +7 more
doaj   +1 more source

Hydrochemical and quality assessment of irrigation water at the trans-himalayan high-altitude regions of Leh, Ladakh, India

Applied Water Science, 2022
A total of seventy irrigation water samples were collected from Leh, Ladakh, India, to determine their hydrochemistry profile and water quality for irrigation purposes.
Arup Giri, Vijay K. Bharti, Sahil Kalia, Krishna Kumar, Mayarngam Khansu   +4 more
doaj   +1 more source

Remote ischemic preconditioning improves cognitive control in healthy adults: Evidence from an event-related potential study

Frontiers in Neuroscience, 2022
It is suggested that remote ischemic preconditioning (RIPC) may be a promising treatment for improving healthy adults’ cognitive control. However, direct empirical evidence was absent. Therefore, this study aims to provide evidence for the impact of RIPC
Yaling Li, Yaling Li, Yaling Li, Pei Huang, Pei Huang, Pei Huang, Jun Huang, Zhifeng Zhong, Zhifeng Zhong, Zhifeng Zhong, Simin Zhou, Simin Zhou, Simin Zhou, Huaping Dong, Huaping Dong, Huaping Dong, Jiaxin Xie, Jiaxin Xie, Jiaxin Xie, Yu Wu, Yu Wu, Yu Wu, Peng Li, Peng Li, Peng Li   +24 more
doaj   +1 more source

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source