Results 131 to 140 of about 3,896,846 (293)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Three Years of High-contrast Imaging of the PDS 70 b and c Exoplanets at Hα with MagAO-X: Evidence of Strong Protoplanet Hα Variability and Circumplanetary Dust

The Astronomical Journal
We present 3 yr of high-contrast imaging of the PDS 70 b and c accreting protoplanets with the new extreme AO system MagAO-X as part of the MaxProtoPlanetS survey of H α protoplanets.
Laird M. Close, Jared R. Males, Jialin Li, Sebastiaan Y. Haffert, Joseph D. Long, Alexander D. Hedglen, Alycia J. Weinberger, Katherine B. Follette, Daniel Apai, Rene Doyon, Warren Foster, Victor Gasho, Kyle Van Gorkom, Olivier Guyon, Maggie Y. Kautz, Jay Kueny, Jennifer Lumbres, Avalon McLeod, Eden McEwen, Clarissa Pavao, Logan Pearce, Laura Perez, Lauren Schatz, Judit Szulágyi, Kevin Wagner, Ya-Lin Wu   +25 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

The JWST Early Release Science Program for Direct Observations of Exoplanetary Systems. VI. Evidence for Radially Evolving Icy Grains in the HD 141569A Disk via NIRCam Coronagraphic Imaging

The Astrophysical Journal
We present JWST NIRCam coronagraphic observations of the HD 141569A circumstellar disk, obtained as part of the JWST Early Release Science program. The observations recover the multi-ringed structure seen in previous shorter-wavelength observations, but ...
Maxwell A. Millar-Blanchaer, Élodie Choquet, Kellen Lawson, Sebastián Marino, Jens Kammerer, Aarynn L. Carter, Isabel Rebollido, Jarron M. Leisenring, Minjae Kim, Paul Kalas, Karl R Stapelfeldt, Sasha Hinkley, Mark Booth, Carol A. Grady, Elisabeth C. Matthews, Beth A. Biller, Andrew Skemer, Julien H. Girard, Schuyler G. Wolff, Kimberly Ward-Duong, Michael R. Meyer, Anthony Boccaletti, Eric Pantin, Brenda C. Matthews, Stanimir Metchev, Marshall D. Perrin, Christine H. Chen, Katie Crotts, Olivier Absil, William O. Balmer, Per Calissendorff, Gabriele Cugno, Thayne Currie, Camilla Danielski, Kielan K. W. Hoch, Markus Janson, Elena Manjavacas, Pierre-Olivier Lagage, Ben J. Sutlieff, Shrishmoy Ray, Bin B. Ren, Emily Rickman, Genaro Suárez, Christopher A. Theissen, Taichi Uyama, Andreas Quirrenbach, Jason J. Wang, Niall Whiteford, Mark C. Wyatt, Alice Zurlo, (The JWST ERS Collaboration)   +50 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

High-resolution Chemical Imaging by Phase Contrast Technique

Materia Japan, 2006
Chihiro Iwamoto, Shinobu Satonaka, Takahisa Yamamoto, Hirofumi Matsuhata, Yuuichi Ikuhara   +4 more
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Emerging optical nanoscopy techniques

Nanotechnology, Science and Applications, 2015
Paul C Montgomery, Audrey Leong-Hoi Laboratoire des Sciences de l'Ingénieur, de l'Informatique et de l'Imagerie (ICube), Unistra-CNRS, Strasbourg, France Abstract: To face the challenges of modern health care, new imaging techniques ...
Montgomery PC, Leong-Hoi A
doaj  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source