Results 131 to 140 of about 21,693,337 (313)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Searching for Protoplanets around MWC 758 and MWC 480 in Br-γ Using Kernel Phase and SCExAO/CHARIS

The Astronomical Journal
Discovering new actively accreting protoplanets is crucial to answering open questions about planet formation. However, identifying such planets at orbital distances where they are expected to be abundant is extremely challenging, both due to the ...
Alexander Chaushev, Steph Sallum, Julien Lozi, Jeffrey Chilcote, Tyler Groff, Olivier Guyon, N. Jeremy Kasdin, Barnaby Norris, Andy Skemer   +8 more
doaj   +1 more source

Application of deep learning techniques for exoplanet detection in high contrast imaging

, 2023
The direct imaging of exoplanets through 10-m class ground-based telescopes is now a reality of modern astrophysics. Reaching this milestone is the re- sult of significant advances in the field of high-contrast imaging, marked by the development of dedicated telescope instrumentation, including extreme adaptive optics and advanced coronagraphy. However,
openaire   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

JWST/NIRCam Imaging of Young Stellar Objects. I. Constraints on Planets Exterior to the Spiral Disk Around MWC 758

The Astronomical Journal
MWC 758 is a young star hosting a spiral protoplanetary disk. The spirals are likely companion-driven, and two previously identified candidate companions have been identified—one at the end the Southern spiral arm at ∼0.″6, and one interior to the gap at
Kevin Wagner, Jarron Leisenring, Gabriele Cugno, Camryn Mullin, Ruobing Dong, Schuyler G. Wolff, Thomas Greene, Doug Johnstone, Michael R. Meyer, Charles Beichman, Martha Boyer, Scott Horner, Klaus Hodapp, Doug Kelly, Don McCarthy, Tom Roellig, George Rieke, Marcia Rieke, Michael Sitko, John Stansberry, Erick Young   +20 more
doaj   +1 more source

High and low contrast acuity and clinical contrast sensitivity tested in a normal population

, 1989
Visual acuities obtained with a high contrast Bailey-Lovie chart (HCBL) and a low contrast Bailey-Lovie chart (LCBL) were compared with clinical contrast sensitivity function (CSF) measurements in a group of normal subjects with a wide range of ...
Lovie-Kitchin, Jan E., Brown, Brian
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Gemini Planet Imager Observations of a Resolved Low-inclination Debris Disk around HD 156623

The Astronomical Journal
The 16 Myr old A0V star HD 156623 in the Scorpius–Centaurus association hosts a high-fractional-luminosity debris disk, recently resolved in scattered light for the first time by the Gemini Planet Imager (GPI) in polarized intensity only.
Briley L. Lewis, Michael P. Fitzgerald, Thomas M. Esposito, Pauline Arriaga, Ronald López, Katie A. Crotts, Gaspard Duchêne, Katherine B. Follette, Justin Hom, Paul Kalas, Brenda C. Matthews, Maxwell Millar-Blanchaer, David J. Wilner, Johan Mazoyer, Bruce Macintosh   +14 more
doaj   +1 more source