Results 131 to 140 of about 1,420,424 (313)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Gemini Planet Imager Observations of a Resolved Low-inclination Debris Disk around HD 156623

The Astronomical Journal
The 16 Myr old A0V star HD 156623 in the Scorpius–Centaurus association hosts a high-fractional-luminosity debris disk, recently resolved in scattered light for the first time by the Gemini Planet Imager (GPI) in polarized intensity only.
Briley L. Lewis, Michael P. Fitzgerald, Thomas M. Esposito, Pauline Arriaga, Ronald López, Katie A. Crotts, Gaspard Duchêne, Katherine B. Follette, Justin Hom, Paul Kalas, Brenda C. Matthews, Maxwell Millar-Blanchaer, David J. Wilner, Johan Mazoyer, Bruce Macintosh   +14 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Application of deep learning techniques for exoplanet detection in high contrast imaging

, 2023
The direct imaging of exoplanets through 10-m class ground-based telescopes is now a reality of modern astrophysics. Reaching this milestone is the re- sult of significant advances in the field of high-contrast imaging, marked by the development of dedicated telescope instrumentation, including extreme adaptive optics and advanced coronagraphy. However,
openaire   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Progress on optical verification for occulter-based high contrast imaging

, 2013
An external occulter is a specially-shaped spacecraft flown in formation with a telescope. It enables high-contrast imaging of the dim planetary companions of the neighboring solar system by blocking starlight before it reaches the entrance pupil ...
Sirbu, D, N. Jeremy Kasdin, Vanderbei, Robert J., Robert J. Vanderbei, Kasdin, NJ, Dan Sirbu   +5 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Advanced Data Processing Techniques for Exoplanet Detection in High Contrast Images

, 2022
High contrast imaging (HCI) is one of the most challenging techniques for exoplanet detection, but also one of the most promising. The main difficulties encountered with HCI arise from the small angular separation between the host star and the potential exoplanets, the flux ratio between them, and the image degradation caused by the Earth's atmosphere.
openaire   +1 more source

Multiscale Solution Techniques For High-Contrast Anisotropic Problems [PDF]

, 2016
Anisotropy occurs in a wide range of applications. Examples include porous media, composite materials, heat transfer, and other fields in science and engineering.
Ren, Jun
core  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source