Results 111 to 120 of about 21,693,337 (313)
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
With JWST, we are directly imaging cold (∼200–300 K) solar-age giant exoplanets for the first time. At these temperatures, many molecular features appear, and water-ice clouds may condense and affect the emission spectrum; early photometric measurements ...
Elisabeth C. Matthews +11 more
doaj +1 more source
An efficient super-resolution approach for obtaining isotropic 3-D imaging using 2-D multi-slice MRI
An approach for obtaining both a high-resolution and high-contrast 3D MRI image volume, desirable for image-guided minimally invasive brain surgery, is proposed. Current MRI imaging techniques, especially in situations where contrast requirements dictate
Alaa A. Hefnawy
doaj +1 more source
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Efficient Exoplanet Imaging Simulations of the Habitable Worlds Observatory
Direct imaging simulations of starshades and other proposed mission concepts are needed to characterize planet detection performance and inform mission design trades.
Jamila S. Taaki +4 more
doaj +1 more source
Contrast-induced nephropathy is a serious complication after intravascular administration of iodinated contrast media and is associated with numerous adverse outcomes.
Jerzy Sacha +3 more
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
The upcoming Roman Coronagraph will be the first high-contrast instrument in space capable of high-order wave front sensing and control technologies, a critical technology demonstration for the proposed Habitable Worlds Observatory (HWO) that aims to ...
Justin Hom +30 more
doaj +1 more source
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
A MIRI Search for Planets and Dust around WD 2149+021
The launch of JWST has ushered in a new era of high-precision infrared astronomy, allowing us to probe nearby white dwarfs for cold dust, exoplanets, and tidally heated exomoons.
Sabrina Poulsen +11 more
doaj +1 more source

