Results 91 to 100 of about 1,474,036 (268)
The Astronomical JournalWe report the detection of a new brown dwarf companion to HIP 17453 A, a chemically peculiar A0V star located at a distance of 81 pc. HIP 17453 A was observed with high-resolution adaptive-optics imaging using the Near-Infrared Camera 2 on the Keck II ...
Marah Brinjikji +28 more
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Photometric Variability and Rotation of β Pictoris b from JWST NIRCam Coronagraphic Imaging
The Astronomical JournalWe report the detection of photometric variability in the directly imaged super-Jupiter β Pictoris b ( β Pic b). Using JWST NIRCam dual-band coronagraphic imaging, we conducted a 16 hr continuous photometric monitoring campaign in the F210M and F410M ...
Yifan Zhou +30 more
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Efficient Exoplanet Imaging Simulations of the Habitable Worlds Observatory
The Astronomical JournalDirect imaging simulations of starshades and other proposed mission concepts are needed to characterize planet detection performance and inform mission design trades.
Jamila S. Taaki +4 more
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Application of deep learning techniques for exoplanet detection in high contrast imaging
, 2023 The direct imaging of exoplanets through 10-m class ground-based telescopes is now a reality of modern astrophysics. Reaching this milestone is the re- sult of significant advances in the field of high-contrast imaging, marked by the development of dedicated telescope instrumentation, including extreme adaptive optics and advanced coronagraphy. However,
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Searching for Protoplanets around MWC 758 and MWC 480 in Br-γ Using Kernel Phase and SCExAO/CHARIS
The Astronomical JournalDiscovering new actively accreting protoplanets is crucial to answering open questions about planet formation. However, identifying such planets at orbital distances where they are expected to be abundant is extremely challenging, both due to the ...
Alexander Chaushev +8 more
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