Results 81 to 90 of about 1,474,036 (268)

CoronaGraph Instrument Reference Stars for Exoplanets (CorGI-REx). I. Preliminary Vetting and Implications for the Roman Coronagraph and Habitable Worlds Observatory

The Astronomical Journal
The upcoming Roman Coronagraph will be the first high-contrast instrument in space capable of high-order wave front sensing and control technologies, a critical technology demonstration for the proposed Habitable Worlds Observatory (HWO) that aims to ...
Justin Hom, Schuyler G. Wolff, Catherine A. Clark, David R. Ciardi, Sarah J. Deveny, Steve B. Howell, Alexandra Z. Greenbaum, Colin Littlefield, Ramya M. Anche, Vanessa P. Bailey, Wolfgang Brandner, Gaël Chauvin, Julien H. Girard, Brian Kern, Eric Mamajek, Bertrand Mennesson, Dmitry Savransky, Karl R. Stapelfeldt, Beth A. Biller, Marah Brinjikji, Masayuki Kuzuhara, Maxwell A. Millar-Blanchaer, Toshiyuki Mizuki, Nicholas T. Schragal, Macarena C. Vega-Pallauta, Jason J. Wang, Robert J. De Rosa, Ewan S. Douglas, Bruce Macintosh, Jingwen Zhang, The Roman Coronagraph Community Participation Program   +30 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

High-frequency Ultrasound Detection Technique with Contrast Agents [PDF]

Sensors and Materials, 2019
Wu, Jian-Xing, Chao, Kuei-Hsiang, Lai, Hsiang-Yueh, Liu, Jian-Hung, Chung, Howard, Liu, Hsiao-Chuan   +5 more
openaire   +1 more source

A MIRI Search for Planets and Dust around WD 2149+021

The Astronomical Journal
The launch of JWST has ushered in a new era of high-precision infrared astronomy, allowing us to probe nearby white dwarfs for cold dust, exoplanets, and tidally heated exomoons.
Sabrina Poulsen, John Debes, Misty Cracraft, Susan E. Mullally, William T. Reach, Mukremin Kilic, Fergal Mullally, Loic Albert, Katherine Thibault, J. J. Hermes, Thomas Barclay, Elisa V. Quintana   +11 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Linear Polarization Variations and Circular Polarization Are Common among Airless Bodies

The Planetary Science Journal
Using the POLISH2 polarimeter at the Lick Observatory Shane 3 m and Nickel 1 m telescopes, we discover rotation-phase-locked variations in linear polarization to be common among asteroids and a near-Earth object (NEO) in a clear, 383−720 nm bandpass ...
Sloane J. Wiktorowicz, Amanda J. Bayless, Larissa A. Nofi   +2 more
doaj   +1 more source

Vascularisation Pattern of Chronic Pancreatitis Compared with Pancreatic Carcinoma: Results from Contrast-Enhanced Endoscopic Ultrasound

International Journal of Inflammation, 2012
Discriminating between focal chronic pancreatitis and pancreatic cancer is always a challenge in clinical medicine. Contrast-enhanced endoscopic ultrasound using Doppler techniques can uniquely reveal different vascularisation patterns in pancreatic ...
Michael Hocke, Christoph F. Dietrich
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A Scatter of Light from a Polarized World

The Astronomical Journal
Many known exoplanets harbor clouds, which lead to degeneracies in spectroscopic models between particle composition and size. Polarimetry, however, provides independent assessment.
Sloane J. Wiktorowicz, Pushkar Kopparla, Jiazheng Li, Yuk L. Yung   +3 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source