Results 61 to 70 of about 1,420,424 (313)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Direct Images of CO2 Absorption in the Atmosphere of a Super-Jupiter: Enhanced Metallicity Suggestive of Formation in a Disk

The Astrophysical Journal Letters
It is unclear how directly imaged substellar companions with masses near the deuterium burning limit form, because these objects are rare and their bulk properties are not diagnostic of their formation.
William O. Balmer, Laurent Pueyo, Ashley Messier, Evelyn Bruinsma, Jeremy Jones, Klara Matuszewska, Marshall D. Perrin, Julien H. Girard, Jarron M. Leisenring, Kellen Lawson, Roeland P. van der Marel, Jens Kammerer, Aarynn Carter, Mathilde Mâlin, Kimberly Ward-Duong, Kielan K. W. Hoch, Emily Rickman, Sara Seager   +17 more
doaj   +1 more source

Nonlinear temporal pulse cleaning techniques and application

High Power Laser Science and Engineering, 2013
Two different pulse cleaning techniques for ultra-high contrast laser systems are comparably analysed in this work. The first pulse cleaning technique is based on noncollinear femtosecond optical-parametric amplification (NOPA) and second-harmonic ...
Yi Xu, Jianzhou Wang, Yansui Huang, Yanyan Li, Xiaomin Lu, Yuxin Leng   +5 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

High-Contrast Fluorescence Microscopy for a Biomolecular Analysis Based on Polarization Techniques Using an Optical Interference Mirror Slide

Biosensors, 2014
Fluorescence microscopy with an improved contrast for fluorescence images is developed using an optical interference mirror (OIM) slide, which can enhance the fluorescence from a fluorophore as a result of the double interference of the excitation light ...
Mitsuru Yasuda, Takuo Akimoto
doaj   +1 more source

Coincident electron channeling and cathodoluminescence studies of threading dislocations in GaN

, 2014
We combine two scanning electron microscopy techniques to investigate the influence of dislocations on the light emission from nitride semiconductors.
Edwards, P. R., Bruckbauer, J., Oliver, R. A., Kraeusel, S., Moram, M. A., Lovelock, S., Trager-Cowan, C., Naresh-Kumar, G., Martin, R. W., Humphreys, C. J., Hourahine, B., Kappers, M. J.   +11 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

JWST/NIRCam Detection of the Fomalhaut C Debris Disk in Scattered Light

The Astrophysical Journal Letters
Observations of debris disks offer important insights into the formation and evolution of planetary systems. Though M dwarfs make up approximately 80% of nearby stars, very few M dwarf debris disks have been studied in detail—making it unclear how or if ...
Kellen Lawson, Joshua E. Schlieder, Jarron M. Leisenring, Ell Bogat, Charles A. Beichman, Geoffrey Bryden, András Gáspár, Tyler D. Groff, Michael W. McElwain, Michael R. Meyer, Thomas Barclay, Per Calissendorff, Matthew De Furio, Yiting Li, Marcia J. Rieke, Marie Ygouf, Thomas P. Greene, Julien H. Girard, Mario Gennaro, Jens Kammerer, Armin Rest, Thomas L. Roellig, Ben Sunnquist   +22 more
doaj   +1 more source

Comparing x-ray phase-contrast imaging using a Talbot array illuminator to propagation-based imaging for non-homogeneous biomedical samples

Scientific Reports, 2023
Phase-contrast computed tomography can visualize soft tissue samples with high contrast. At coherent sources, propagation-based imaging (PBI) techniques are among the most common, as they are easy to implement and produce high-resolution images.
Mirko Riedel, Kirsten Taphorn, Alex Gustschin, Madleen Busse, Joerg U. Hammel, Julian Moosmann, Felix Beckmann, Florian Fischer, Pierre Thibault, Julia Herzen   +9 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source