Results 41 to 50 of about 1,474,036 (268)

JWST-TST High Contrast: Living on the Wedge, or, NIRCam Bar Coronagraphy Reveals CO2 in the HR 8799 and 51 Eri Exoplanets’ Atmospheres

The Astronomical Journal
High-contrast observations with JWST can reveal key composition and vertical mixing dependent absorption features in the spectra of directly imaged planets across the 3–5 μ m wavelength range.
William O. Balmer, Jens Kammerer, Laurent Pueyo, Marshall D. Perrin, Julien H. Girard, Jarron M. Leisenring, Kellen Lawson, Henry Dennen, Roeland P. van der Marel, Charles A. Beichman, Geoffrey Bryden, Jorge Llop-Sayson, Jeff A. Valenti, Joshua D. Lothringer, Nikole K. Lewis, Mathilde Mâlin, Isabel Rebollido, Emily Rickman, Kielan K. W. Hoch, Rémi Soummer, Mark Clampin, C. Matt Mountain   +21 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Wide-spectral-band Nuller Insensitive to Finite Stellar Angular Diameter with a One-dimensional Diffraction-limited Coronagraph

The Astronomical Journal
Potentially habitable planets around nearby stars less massive than solar-type stars could join targets of the spectroscopy of the planetary reflected light with future space telescopes.
Satoshi Itoh, Taro Matsuo, Motohide Tamura   +2 more
doaj   +1 more source

Towards non-contact photoacoustic imaging [review]

Photoacoustics, 2020
Photoacoustic imaging (PAI) takes advantage of both optical and ultrasound imaging properties to visualize optical absorption with high resolution and contrast.
Zohreh Hosseinaee, Martin Le, Kevan Bell, Parsin Haji Reza   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Follow-up Exploration of the TWA 7 Planet–Disk System with JWST NIRCam

The Astrophysical Journal Letters
The young M star TWA 7 hosts a bright and near face-on debris disk, which has been imaged from the optical to the submillimeter. The disk displays multiple complex substructures such as three disk components, a large dust clump, and spiral arms ...
Katie A. Crotts, Aarynn L. Carter, Kellen Lawson, James Mang, Beth Biller, Mark Booth, Rodrigo Ferrer-Chavez, Julien H. Girard, Anne-Marie Lagrange, Michael C. Liu, Sebastian Marino, Maxwell A. Millar-Blanchaer, Andy Skemer, Giovanni M. Strampelli, Jason Wang, Olivier Absil, William O. Balmer, Raphaël Bendahan-West, Ellis Bogat, Rachel Bowens-Rubin, Gaël Chauvin, Clémence Fontanive, Kyle Franson, Jens Kammerer, Jarron Leisenring, Caroline V. Morley, Isabel Rebollido, Nour Skaf, Ben J. Sutlieff, Evelyn L. Bruinsma, Sasha Hinkley, Kielan Hoch, Andrew D. James, Rohan Kane, Dimitri Mawet, Michael R. Meyer, Skyler Palatnick, Marshall D. Perrin, Shrishmoy Ray, Emily Rickman, Aniket Sanghi, Klaus Subbotina Stephenson   +41 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Direct Images of CO2 Absorption in the Atmosphere of a Super-Jupiter: Enhanced Metallicity Suggestive of Formation in a Disk

The Astrophysical Journal Letters
It is unclear how directly imaged substellar companions with masses near the deuterium burning limit form, because these objects are rare and their bulk properties are not diagnostic of their formation.
William O. Balmer, Laurent Pueyo, Ashley Messier, Evelyn Bruinsma, Jeremy Jones, Klara Matuszewska, Marshall D. Perrin, Julien H. Girard, Jarron M. Leisenring, Kellen Lawson, Roeland P. van der Marel, Jens Kammerer, Aarynn Carter, Mathilde Mâlin, Kimberly Ward-Duong, Kielan K. W. Hoch, Emily Rickman, Sara Seager   +17 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source