Results 101 to 110 of about 3,896,846 (293)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Efficient Exoplanet Imaging Simulations of the Habitable Worlds Observatory

The Astronomical Journal
Direct imaging simulations of starshades and other proposed mission concepts are needed to characterize planet detection performance and inform mission design trades.
Jamila S. Taaki, Farzad Kamalabadi, Athol J. Kemball, Lia Corrales, Alfred O. Hero III   +4 more
doaj   +1 more source

Contrast Enhanced MRI in the Diagnosis of HCC

Diagnostics, 2015
Hepatocellular carcinoma (HCC) is the 6th most common cancer worldwide. Imaging plays a critical role in HCC screening and diagnosis. Initial screening of patients at risk for HCC is performed with ultrasound.
Eric Niendorf, Benjamin Spilseth, Xiao Wang, Andrew Taylor   +3 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

CoronaGraph Instrument Reference Stars for Exoplanets (CorGI-REx). I. Preliminary Vetting and Implications for the Roman Coronagraph and Habitable Worlds Observatory

The Astronomical Journal
The upcoming Roman Coronagraph will be the first high-contrast instrument in space capable of high-order wave front sensing and control technologies, a critical technology demonstration for the proposed Habitable Worlds Observatory (HWO) that aims to ...
Justin Hom, Schuyler G. Wolff, Catherine A. Clark, David R. Ciardi, Sarah J. Deveny, Steve B. Howell, Alexandra Z. Greenbaum, Colin Littlefield, Ramya M. Anche, Vanessa P. Bailey, Wolfgang Brandner, Gaël Chauvin, Julien H. Girard, Brian Kern, Eric Mamajek, Bertrand Mennesson, Dmitry Savransky, Karl R. Stapelfeldt, Beth A. Biller, Marah Brinjikji, Masayuki Kuzuhara, Maxwell A. Millar-Blanchaer, Toshiyuki Mizuki, Nicholas T. Schragal, Macarena C. Vega-Pallauta, Jason J. Wang, Robert J. De Rosa, Ewan S. Douglas, Bruce Macintosh, Jingwen Zhang, The Roman Coronagraph Community Participation Program   +30 more
doaj   +1 more source

Vascularisation Pattern of Chronic Pancreatitis Compared with Pancreatic Carcinoma: Results from Contrast-Enhanced Endoscopic Ultrasound

International Journal of Inflammation, 2012
Discriminating between focal chronic pancreatitis and pancreatic cancer is always a challenge in clinical medicine. Contrast-enhanced endoscopic ultrasound using Doppler techniques can uniquely reveal different vascularisation patterns in pancreatic ...
Michael Hocke, Christoph F. Dietrich
doaj   +1 more source

Reducing the Number of Annotations in a Verification-oriented Imperative Language [PDF]

, 2009
Automated software verification is a very active field of research which has made enormous progress both in theoretical and practical aspects. Recently, an important amount of research effort has been put into applying these techniques on top of ...
de Caso, Guido, Garbervetsky, Diego, Gorín, Daniel   +2 more
core   +1 more source

High-frequency Ultrasound Detection Technique with Contrast Agents [PDF]

Sensors and Materials, 2019
Jian-Xing Wu, Kuei-Hsiang Chao, Hsiang-Yueh Lai, Jian-Hung Liu, Howard Chung, Hsiao-Chuan Liu   +5 more
openaire   +1 more source

High-sensitive Optical Pulse-Shape Characterization using a Beating-Contrast-Measurement Technique

, 2014
Ultrahigh-speed optical transmission technology, such as optical time domain multiplexing or optical signal processing is a key point for increasing the communication capacity. The system performances are strongly related to pulse properties. We present an original method dedicated to short pulse-shape characterization with high repetition rate using ...
Roncin, Vincent, Fève, Sylvain, Millaud, Audrey, Cramer, Romain, Jaouën, Yves, Simon, Jean-Claude   +5 more
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source