Results 101 to 110 of about 1,420,424 (313)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

A Second Visit to Eps Ind Ab with JWST: New Photometry Confirms Ammonia and Suggests Thick Clouds in the Exoplanet Atmosphere of the Closest Super-Jupiter

The Astrophysical Journal Letters
With JWST, we are directly imaging cold (∼200–300 K) solar-age giant exoplanets for the first time. At these temperatures, many molecular features appear, and water-ice clouds may condense and affect the emission spectrum; early photometric measurements ...
Elisabeth C. Matthews, James Mang, Aarynn L. Carter, Mathlide Mâlin, Caroline V. Morley, Bhavesh Rajpoot, Leindert A. Boogaard, Jennifer A. Burt, Ian J. M. Crossfield, Fabo Feng, Anne- Marie Lagrange, Mark W. Phillips   +11 more
doaj   +1 more source

Double-sided fresnel zone plates as high performance optics in X-ray microscopy [PDF]

, 2015
X-ray microscopy describes a range of analytical techniques, specialized for the characterization of organic and inorganic samples using high energy photons.
Mohácsi, István
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Efficient Exoplanet Imaging Simulations of the Habitable Worlds Observatory

The Astronomical Journal
Direct imaging simulations of starshades and other proposed mission concepts are needed to characterize planet detection performance and inform mission design trades.
Jamila S. Taaki, Farzad Kamalabadi, Athol J. Kemball, Lia Corrales, Alfred O. Hero III   +4 more
doaj   +1 more source

Contrast Enhanced MRI in the Diagnosis of HCC

Diagnostics, 2015
Hepatocellular carcinoma (HCC) is the 6th most common cancer worldwide. Imaging plays a critical role in HCC screening and diagnosis. Initial screening of patients at risk for HCC is performed with ultrasound.
Eric Niendorf, Benjamin Spilseth, Xiao Wang, Andrew Taylor   +3 more
doaj   +1 more source

Adaptive Optics for High-Contrast Imaging

, 2006
This paper deals with adaptive optics in the framework of very high-contrast astronomical imaging. Starting from a brief global overview of classical adaptive optics (AO) systems, the specificities and main characteristics of extreme AO (XAO) systems are
M. Carbillet
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

CoronaGraph Instrument Reference Stars for Exoplanets (CorGI-REx). I. Preliminary Vetting and Implications for the Roman Coronagraph and Habitable Worlds Observatory

The Astronomical Journal
The upcoming Roman Coronagraph will be the first high-contrast instrument in space capable of high-order wave front sensing and control technologies, a critical technology demonstration for the proposed Habitable Worlds Observatory (HWO) that aims to ...
Justin Hom, Schuyler G. Wolff, Catherine A. Clark, David R. Ciardi, Sarah J. Deveny, Steve B. Howell, Alexandra Z. Greenbaum, Colin Littlefield, Ramya M. Anche, Vanessa P. Bailey, Wolfgang Brandner, Gaël Chauvin, Julien H. Girard, Brian Kern, Eric Mamajek, Bertrand Mennesson, Dmitry Savransky, Karl R. Stapelfeldt, Beth A. Biller, Marah Brinjikji, Masayuki Kuzuhara, Maxwell A. Millar-Blanchaer, Toshiyuki Mizuki, Nicholas T. Schragal, Macarena C. Vega-Pallauta, Jason J. Wang, Robert J. De Rosa, Ewan S. Douglas, Bruce Macintosh, Jingwen Zhang, The Roman Coronagraph Community Participation Program   +30 more
doaj   +1 more source

Vascularisation Pattern of Chronic Pancreatitis Compared with Pancreatic Carcinoma: Results from Contrast-Enhanced Endoscopic Ultrasound

International Journal of Inflammation, 2012
Discriminating between focal chronic pancreatitis and pancreatic cancer is always a challenge in clinical medicine. Contrast-enhanced endoscopic ultrasound using Doppler techniques can uniquely reveal different vascularisation patterns in pancreatic ...
Michael Hocke, Christoph F. Dietrich
doaj   +1 more source