Results 101 to 110 of about 1,474,036 (268)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

JWST/NIRCam Imaging of Young Stellar Objects. I. Constraints on Planets Exterior to the Spiral Disk Around MWC 758

The Astronomical Journal
MWC 758 is a young star hosting a spiral protoplanetary disk. The spirals are likely companion-driven, and two previously identified candidate companions have been identified—one at the end the Southern spiral arm at ∼0.″6, and one interior to the gap at
Kevin Wagner, Jarron Leisenring, Gabriele Cugno, Camryn Mullin, Ruobing Dong, Schuyler G. Wolff, Thomas Greene, Doug Johnstone, Michael R. Meyer, Charles Beichman, Martha Boyer, Scott Horner, Klaus Hodapp, Doug Kelly, Don McCarthy, Tom Roellig, George Rieke, Marcia Rieke, Michael Sitko, John Stansberry, Erick Young   +20 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Gemini Planet Imager Observations of a Resolved Low-inclination Debris Disk around HD 156623

The Astronomical Journal
The 16 Myr old A0V star HD 156623 in the Scorpius–Centaurus association hosts a high-fractional-luminosity debris disk, recently resolved in scattered light for the first time by the Gemini Planet Imager (GPI) in polarized intensity only.
Briley L. Lewis, Michael P. Fitzgerald, Thomas M. Esposito, Pauline Arriaga, Ronald López, Katie A. Crotts, Gaspard Duchêne, Katherine B. Follette, Justin Hom, Paul Kalas, Brenda C. Matthews, Maxwell Millar-Blanchaer, David J. Wilner, Johan Mazoyer, Bruce Macintosh   +14 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Advanced Data Processing Techniques for Exoplanet Detection in High Contrast Images

, 2022
High contrast imaging (HCI) is one of the most challenging techniques for exoplanet detection, but also one of the most promising. The main difficulties encountered with HCI arise from the small angular separation between the host star and the potential exoplanets, the flux ratio between them, and the image degradation caused by the Earth's atmosphere.
openaire   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Three Years of High-contrast Imaging of the PDS 70 b and c Exoplanets at Hα with MagAO-X: Evidence of Strong Protoplanet Hα Variability and Circumplanetary Dust

The Astronomical Journal
We present 3 yr of high-contrast imaging of the PDS 70 b and c accreting protoplanets with the new extreme AO system MagAO-X as part of the MaxProtoPlanetS survey of H α protoplanets.
Laird M. Close, Jared R. Males, Jialin Li, Sebastiaan Y. Haffert, Joseph D. Long, Alexander D. Hedglen, Alycia J. Weinberger, Katherine B. Follette, Daniel Apai, Rene Doyon, Warren Foster, Victor Gasho, Kyle Van Gorkom, Olivier Guyon, Maggie Y. Kautz, Jay Kueny, Jennifer Lumbres, Avalon McLeod, Eden McEwen, Clarissa Pavao, Logan Pearce, Laura Perez, Lauren Schatz, Judit Szulágyi, Kevin Wagner, Ya-Lin Wu   +25 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source