Results 121 to 130 of about 3,896,846 (293)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

JWST/NIRCam Imaging of Young Stellar Objects. I. Constraints on Planets Exterior to the Spiral Disk Around MWC 758

The Astronomical Journal
MWC 758 is a young star hosting a spiral protoplanetary disk. The spirals are likely companion-driven, and two previously identified candidate companions have been identified—one at the end the Southern spiral arm at ∼0.″6, and one interior to the gap at
Kevin Wagner, Jarron Leisenring, Gabriele Cugno, Camryn Mullin, Ruobing Dong, Schuyler G. Wolff, Thomas Greene, Doug Johnstone, Michael R. Meyer, Charles Beichman, Martha Boyer, Scott Horner, Klaus Hodapp, Doug Kelly, Don McCarthy, Tom Roellig, George Rieke, Marcia Rieke, Michael Sitko, John Stansberry, Erick Young   +20 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Gemini Planet Imager Observations of a Resolved Low-inclination Debris Disk around HD 156623

The Astronomical Journal
The 16 Myr old A0V star HD 156623 in the Scorpius–Centaurus association hosts a high-fractional-luminosity debris disk, recently resolved in scattered light for the first time by the Gemini Planet Imager (GPI) in polarized intensity only.
Briley L. Lewis, Michael P. Fitzgerald, Thomas M. Esposito, Pauline Arriaga, Ronald López, Katie A. Crotts, Gaspard Duchêne, Katherine B. Follette, Justin Hom, Paul Kalas, Brenda C. Matthews, Maxwell Millar-Blanchaer, David J. Wilner, Johan Mazoyer, Bruce Macintosh   +14 more
doaj   +1 more source

Advanced Data Processing Techniques for Exoplanet Detection in High Contrast Images

, 2022
High contrast imaging (HCI) is one of the most challenging techniques for exoplanet detection, but also one of the most promising. The main difficulties encountered with HCI arise from the small angular separation between the host star and the potential exoplanets, the flux ratio between them, and the image degradation caused by the Earth's atmosphere.
openaire   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Sustainable Agricultural Practices and Agricultural Productivity in Ethiopia: Does Agroecology Matter? [PDF]

This paper uses data from household- and plot-level surveys conducted in the highlands of the Tigray and Amhara regions of Ethiopia to examine the contribution of sustainable land-management practices to net values of agricultural production in areas ...
Kassie, Menale, Köhlin, Gunnar, Pender, John, Zikhali, Precious   +3 more
core  

An Adaptive and Non-Linear Technique for Enhancement of High Contrast Images

, 2007
In night time surveillance, there is a possibility of having extremely bright and dark regions in some image frames of a video sequence. Neither the object details in the low intensity areas nor in the high intensity areas can be clearly interpreted. Several image processing techniques have been developed to retrieve meaningful information under low ...
openaire   +2 more sources