Results 121 to 130 of about 1,420,424 (313)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

High-fidelity colour reproduction for high-dynamic-range imaging

, 2010
The aim of this thesis is to develop a colour reproduction system for high-dynamic-range (HDR) imaging. Classical colour reproduction systems fail to reproduce HDR images because current characterisation methods and colour appearance models fail to ...
Kim, M.H.
core  

End-to-end simulation of high-contrast imaging systems: methods and results for the PICTURE mission family

, 2018
We describe a set of numerical approaches to modeling the performance of space flight high-contrast imaging payloads. Mission design for high-contrast imaging requires numerical wavefront error propagation to ensure accurate component specifications. For
Chakrabarti, Supriya, Finn, Susanna C., Cahoy, Kerri, Cook, Timothy A., Mendillo, Christopher B., Kuchner, Marc J., Lewis, Nikole K., Douglas, Ewan S., Mawet, Dimitri, Hewawasam, Kuravi, Howe, Glenn A., Marinan, Anne D.   +11 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Searching for Protoplanets around MWC 758 and MWC 480 in Br-γ Using Kernel Phase and SCExAO/CHARIS

The Astronomical Journal
Discovering new actively accreting protoplanets is crucial to answering open questions about planet formation. However, identifying such planets at orbital distances where they are expected to be abundant is extremely challenging, both due to the ...
Alexander Chaushev, Steph Sallum, Julien Lozi, Jeffrey Chilcote, Tyler Groff, Olivier Guyon, N. Jeremy Kasdin, Barnaby Norris, Andy Skemer   +8 more
doaj   +1 more source

Development of A Computer-Aided Detection (CAD) Tool For Contrast Micro Computed Tomography Imaging In Diagnosing Liver Metastases

, 2012
High morbidity of metastatic tumors in the liver has been observed in several different types of cancers. Liver failure from metastases is one of the primary causes of death in these patients.
Peck, Anderson Steadham
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

JWST/NIRCam Imaging of Young Stellar Objects. I. Constraints on Planets Exterior to the Spiral Disk Around MWC 758

The Astronomical Journal
MWC 758 is a young star hosting a spiral protoplanetary disk. The spirals are likely companion-driven, and two previously identified candidate companions have been identified—one at the end the Southern spiral arm at ∼0.″6, and one interior to the gap at
Kevin Wagner, Jarron Leisenring, Gabriele Cugno, Camryn Mullin, Ruobing Dong, Schuyler G. Wolff, Thomas Greene, Doug Johnstone, Michael R. Meyer, Charles Beichman, Martha Boyer, Scott Horner, Klaus Hodapp, Doug Kelly, Don McCarthy, Tom Roellig, George Rieke, Marcia Rieke, Michael Sitko, John Stansberry, Erick Young   +20 more
doaj   +1 more source

High-contrast pump-probe spectroscopy with high-order harmonics

, 2008
The high order harmonic generation process from molecules can be used to probe the structure of the emitting medium with high spatial resolution [1, 2]. The measurements of molecular dynamics with such a probe is thus very appealing.
Sali\ue8res, P., P.B. Corkum, Breger, P., S. Haessler, Higuet, J., Fabre, B, Corkum, P., M\ue9vel, E., Corkum, P. B., P. Salières, Salières, P., Constant, E, Mairesse, Y., D. Descamps, W. Boutu, Descamps, D, Petit, S, S. Petit, Mével, E., E. Mével, Dudovich, N, E. Constant, P. B. Corkum, Dudovich, N., J. Higuet, D. M. Villeneuve, Haessler, Stefan, Mairesse, Y, Boutu, W., Constant, E., Villeneuve, D., Petit, S., B. Fabre, Fabre, B., Haessler, S., Villeneuve, D.M., Higuet, J, D.M. Villeneuve, Mével, E, Y. Mairesse, P. Breger, Salières, Pascal, Villeneuve, David, Boutu, W, Breger, P, N. Dudovich, Descamps, D., Corkum, P.B.   +47 more
core   +1 more source