Results 101 to 110 of about 1,615,493 (360)

Reengineering Endogenous Targeting Lipid Nanoparticles (ENDO) for Systemic Delivery of mRNA to Pancreas

Advanced Materials, EarlyView.
ENDO lipid nanoparticles containing cholecalciferol as a fifth component demonstrate mRNA delivery to the pancreas with 99% selectivity, including beta cells. This platform shows minimal toxicity and sustained protein expression for up to 3 days in a dose‐dependent manner, offering a novel approach to pancreas‐specific mRNA delivery and gene therapy ...
Ivan Isaac, Luv Patel, Nguyen Tran, Amarnath Singam, DongSoo Yun, Prasun Guha, Seungman Park, Chandrabali Bhattacharya   +7 more
wiley   +1 more source

Current guidelines for high-density lipoprotein cholesterol in therapy and future directions

Vascular Health and Risk Management, 2014
Bishnu H Subedi,1,2 Parag H Joshi,1 Steven R Jones,1 Seth S Martin,1 Michael J Blaha,1 Erin D Michos1 1Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, 2Greater Baltimore Medical Center, Baltimore, MD, USA Abstract: Many studies have ...
Subedi BH, Joshi PH, Jones SR, Martin SS, Blaha MJ, Michos ED   +5 more
doaj  

Heterogeneity of Plasma High Density Lipoproteins* [PDF]

, 1965
Robert I. Levy, Donald S. Fredrickson
openalex   +1 more source

Mechanical Interactions Impact the Functions of Immune Cells and Their Application in Immunoengineering

Advanced Therapeutics, EarlyView.
This review covers the mechanical forces experienced by immune cells through cell–cell and cell–extracellular matrix interactions and how these forces influence their receptors and functions. These relationships between forces and cellular functions can be exploited using engineering techniques to modify the physical properties of materials for novel ...
Yu‐Chang Chen, Nghi M. Tran, Kyle H. Vining   +2 more
wiley   +1 more source

Artificial High Density Lipoprotein Nanoparticles in Cardiovascular Research

Molecules, 2019
Lipoproteins are endogenous nanoparticles which are the major transporter of fats and cholesterol in the human body. They play a key role in the regulatory mechanisms of cardiovascular events.
Karin Kornmueller, Ivan Vidakovic, Ruth Prassl   +2 more
doaj   +1 more source

Optimization of the Isolation Method for Large‐Scale Production of Synthetic Bacterial Vesicles for Cancer Immunotherapy

Advanced Therapeutics, EarlyView.
This study introduces a reliable technique for the large‐scale production of bacterial vesicles that maintain their immune‐modulating potential, enabling industrial manufacturing and clinical applications. Although other cancer immunotherapies are available, this research presents an advanced bacterial vesicle‐based therapeutic option, with scalable ...
Negar Ordouzadeh, Rossella Crescitelli, Agnes Zimmer, Petra Tjärnlund, Cecilia Lässer, Jan Lötvall, Kyong‐Su Park   +6 more
wiley   +1 more source

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

Advanced Therapeutics, EarlyView.
This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar, Weiwei Guo, Xin Shen, Yimeng Fang, Yilin Liu, Peng‐Yuan Wang, Roey Elnathan, Yaping Chen   +7 more
wiley   +1 more source

HDL-apolipoprotein A-I exchange is independently associated with cholesterol efflux capacity

Journal of Lipid Research, 2015
HDL is the primary mediator of cholesterol mobilization from the periphery to the liver via reverse cholesterol transport (RCT). A critical first step in this process is the uptake of cholesterol from lipid-loaded macrophages by HDL, a function of HDL ...
Mark S. Borja, Kit F. Ng, Angela Irwin, Jaekyoung Hong, Xing Wu, Daniel Isquith, Xue-Qiao Zhao, Bryan Prazen, Virginia Gildengorin, Michael N. Oda, Tomáš Vaisar   +10 more
doaj  

Effects of Inclisiran, Alirocumab, Evolocumab, and Evinacumab on Lipids: A Network Meta-Analysis

Reviews in Cardiovascular Medicine
Background: Direct comparisons between the drugs are limited, and the dosing remains debatable. Therefore, the study aims to indirectly compare the efficacy and safety of inclisiran, alirocumab, evolocumab, and evinacumab in lipid ...
Lin Zhang, Bin Li, Wei Chen, Wei Li, Huayun Yang, Diguang Pan   +5 more
doaj   +1 more source

Micro Immunochemical Method for Estimating High- and Low-Density Lipoproteins [PDF]

, 1962
R.L. Searcy, VincentP Carroll, J.S. Carlucci, Lois M. Bergquist   +3 more
openalex   +1 more source