Results 11 to 20 of about 559,532 (297)
High Mobility Group Box 1 in Human Cancer [PDF]
Cells, 2020 High mobility group box 1 (HMGB1) is an extremely versatile protein that is located predominantly in the nucleus of quiescent eukaryotic cells, where it is critically involved in maintaining genomic structure and function. During cellular stress, however,
Bernardo L. Rapoport +6 more
doaj +4 more sources
Role of High-Mobility Group Box-1 in Liver Pathogenesis [PDF]
International Journal of Molecular Sciences, 2019 High-mobility group box 1 (HMGB1) is a highly abundant DNA-binding protein that can relocate to the cytosol or undergo extracellular release during cellular stress or death. HMGB1 has a functional versatility depending on its cellular location. While intracellular HMGB1 is important for DNA structure maintenance, gene expression, and autophagy ...
Bilon Khambu +3 more
openaire +5 more sources
High‐Mobility Group Box‐1 and Liver Disease [PDF]
Hepatology Communications, 2018 High‐mobility group box‐1 (HMGB1) is a ubiquitous protein. While initially thought to be simply an architectural protein due to its DNA‐binding ability, evidence from the last decade suggests that HMGB1 is a key protein participating in the pathogenesis ...
Harriet Gaskell +2 more
doaj +3 more sources
Roles of High Mobility Group Box 1 in Cardiovascular Calcification [PDF]
Cellular Physiology and Biochemistry, 2017 Calcific disease of the cardiovascular system, including atherosclerotic calcification, medial calcification in diabetes and calcific aortic valve disease, is an important risk factor for many adverse cardiovascular events such as ischemic cardiac events
Qiang Chen +3 more
doaj +3 more sources
The Role of High Mobility Group Box 1 in Ischemic Stroke [PDF]
Frontiers in Cellular Neuroscience, 2019 High-mobility group box 1 protein (HMGB1) is a novel, cytokine-like, and ubiquitous, highly conserved, nuclear protein that can be actively secreted by microglia or passively released by necrotic neurons.
Yingze Ye +6 more
doaj +3 more sources
High-Mobility Group Box 1 and Autophagy [PDF]
, 2016 High-mobility group box 1 (HMGB1) is an architectural chromosomal protein and stress sensor that plays a critical role in various physiological and pathological processes, including cell death and survival.
Daolin Tang, Rui Kang
openaire +4 more sources
Identification and characterization of the lamprey high-mobility group box 1 gene. [PDF]
PLoS ONE, 2012 High-mobility group box 1 (HMGB1), a highly conserved DNA-binding protein, plays an important role in maintaining nucleosome structures, transcription, and inflammation. We identified a homolog of HMGB1 in the Japanese lamprey (Lampetra japonica).
Yue Pang, Rong Xiao, Xin Liu, Qingwei Li
doaj +4 more sources
High Mobility Group Box 1 Protein in Cerebral Thromboemboli [PDF]
International Journal of Molecular Sciences, 2021 High-mobility group box 1 protein (HMGB1) is a damage-associated molecular pattern (DAMP) involved in neutrophil extracellular trap (NET) formation and thrombosis. NETs are regularly found in cerebral thromboemboli. We here analyzed associated HMGB1 expression in human thromboemboli retrieved via mechanical thrombectomy from 37 stroke patients with ...
Fabian Essig +9 more
openaire +2 more sources
High-mobility group box 1 and cancer [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2010 High-mobility group box 1 protein (HMGB1), a chromatin associated nuclear protein and extracellular damage associated molecular pattern molecule (DAMP), is an evolutionarily ancient and critical regulator of cell death and survival. Overexpression of HMGB1 is associated with each of the hallmarks of cancer including unlimited replicative potential ...
Daolin, Tang +3 more
openaire +2 more sources
Role of high mobility group box 1 (HMGB1) in SCA17 pathogenesis. [PDF]
PLoS ONE, 2014 Spinocerebellar ataxia type 17 (SCA17) involves the expression of a polyglutamine (polyQ) expanded TATA-binding protein (TBP), a general transcription initiation factor. TBP interacts with other protein factors, including high mobility group box 1 (HMGB1)
Li-Ching Lee +5 more
doaj +1 more source