Results 21 to 30 of about 559,532 (297)

High Mobility Group Box 1 Expression in Oral Inflammation and Regeneration

Frontiers in Immunology, 2020
High mobility group box 1 (HMGB1) is a non-histone DNA-binding protein of about 30 kDa. It is released from a variety of cells into the extracellular milieu in response to inflammatory stimuli and acts on specific cell-surface receptors, such as ...
Keisuke Yamashiro, Hidetaka Ideguchi, Hiroaki Aoyagi, Chiaki Yoshihara-Hirata, Anna Hirai, Risa Suzuki-Kyoshima, Yao Zhang, Hidenori Wake, Masahiro Nishibori, Tadashi Yamamoto, Shogo Takashiba   +10 more
doaj   +1 more source

LPS Primes Brain Responsiveness to High Mobility Group Box-1 Protein

Pharmaceuticals, 2021
High mobility group box (HMGB)1 action contributes to late phases of sepsis, but the effects of increased endogenous plasma HMGB1 levels on brain cells during inflammation are unclear.
Verena Peek, Lois M. Harden, Jelena Damm, Ferial Aslani, Stephan Leisengang, Joachim Roth, Rüdiger Gerstberger, Marita Meurer, Maren von Köckritz-Blickwede, Sabine Schulz, Bernhard Spengler, Christoph Rummel   +11 more
doaj   +1 more source

Mesenchymal-epithelial signalling in tumour microenvironment: role of high-mobility group Box 1. [PDF]

, 2016
Glucose deprivation, hypoxia and acidosis are characteristic features of the central core of most solid tumours. Myofibroblasts are stromal cells present in many such solid tumours, including those of the colon, and are known to be involved in all stages
A Chitanuwat, A Jang, A Rojas, A Yoshida, Andrew Evans, AR Evans, B Hinz, C Holmberg, C Peña, CA Duckworth, CC Lee, D Tang, D Tang, D Yang, E Downs-Kelly, E Hemers, E Ranzato, E Ranzato, Elaine Hemers, F Riuzzi, FP Wang, G Li, H Guan, IE Dumitriu, IE Dumitriu, J Thorburn, J Thorburn, JF Curtin, L Li, M Bustin, M Hu, M Luca, M Mareel, M Mareel, M Tripathi, MB Vaughan, MH Chien, N Mahajan, O Wever De, PN Chen, R Kang, R Kokkola, S Dabiri, S Gardella, S Kim, S Nagarajan, S Werner, Sikander Sharma, SS Lange, T Yeung, W Li, X Yang, Y Liu   +52 more
core   +1 more source

High mobility group box 1 in diabetic nephropathy

Experimental and Therapeutic Medicine, 2017
Type 2 diabetes (T2D) is a complex disorder caused by the combined effects of genetic inheritance and environmental factors. The abnormal secretion of albumin via urine is the characteristic feature of a diabetic nephropathy (DN) patient. Moreover, the detection of this observable characteristic feature of DN is quite late.
Shi, Haitao, Che, Yingqi, Bai, Lin, Zhang, Jinling, Fan, Jingxu, Mao, Huiling   +5 more
openaire   +3 more sources

High Mobility Group Box-1 and Blood–Brain Barrier Disruption

Cells, 2020
Increasing evidence suggests that inflammatory responses are involved in the progression of brain injuries induced by a diverse range of insults, including ischemia, hemorrhage, trauma, epilepsy, and degenerative diseases.
Masahiro Nishibori, Dengli Wang, Daiki Ousaka, Hidenori Wake   +3 more
doaj   +1 more source

From human Megakaryocytes to platelets: Effects of aspirin on high-mobility group Box 1/receptor for advanced glycation end products axis [PDF]

, 2018
Platelets (PLTs) are the major source of high-mobility group box 1 (HMGB1), a protein that is involved in sterile inflammation of blood vessels and thrombosis.
Alessandra Zicari, Emanuela Mari, Fabio M. Pulcinelli, Isabella Massimi, Marco E. Bianchi, Marco Tafani, Marco Tafani, Ornella Morsilli, Raffaella Guerriero, Stefania Mardente   +9 more
core   +2 more sources

Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy [PDF]

, 2017
Approximately 30% of epilepsy patients do not respond to antiepileptic drugs, representing an unmet medical need. There is evidence that neuroinflammation plays a pathogenic role in drug-resistant epilepsy. The high-mobility group box 1 (HMGB1)/TLR4 axis
Alapirtti, Tiina, Antoine, Daniel, Brodie, Martin J., Frigerio, Federica, Jenkins, Rosalind E, Jorgensen, Andrea L, Marson, Anthony Guy, Park, Brian Kevin, Peltola, Jukka, Pirmohamed, Munir, Porcu, Luca, Ravizza, Teresa, Ricci, Emanuele, Sills, Graeme John, Thippeswamy, Thimmasettappa, Tse, Karen, Vezzani, Annamaria, Walker, Lauren Elizabeth   +17 more
core   +3 more sources

Inflammasomes: caspase-1-activating platforms with critical roles in host defense [PDF]

, 2011
Activation of the inflammatory cysteine protease caspase-1 in inflammasome complexes plays a critical role in the host response to microbial infections.
Lieselotte eVande Walle, Lieselotte eVande Walle, Mohamed eLamkanfi, Mohamed eLamkanfi   +3 more
core   +2 more sources

High Mobility Group Box Protein-1 in Wound Repair

Cells, 2012
High-mobility group box 1 protein (HMGB1), a member of highly conserved non-histone DNA binding protein family, has been studied as transcription factor and growth factor.
Mauro Patrone, Marco Pedrazzi, Simona Martinotti, Elia Ranzato   +3 more
doaj   +1 more source

High mobility group box-1 and cardiovascular diseases

Saudi Medical Journal, 2010
High mobility group box-1 (HMGB1) is a highly conserved, ubiquitous protein in the nuclei and cytoplasm of almost all cells. After binding to its receptor, HMGB1, which is derived from necrotic cells and activated macrophages/monocytes, functions as a critical mediator of inflammation and promotes tissue repair and regeneration.
Hua-Sheng, Ding, Jun, Yang
openaire   +2 more sources