Results 31 to 40 of about 559,532 (297)

High mobility group box 1 complexed with heparin induced angiogenesis in a matrigel plug assay [PDF]

, 2009
Angiogenesis involves complex processes mediated by several factors and is associated with inflammation and wound healing. High mobility group box 1 (HMGB1) is released from necrotic cells as well as macrophages and plays proinflammatory roles.
Liu, Keyue, Mori, Shuji, Nishibori, Masahiro, Takahashi, Hideo K., Wake, Hidenori   +4 more
core   +1 more source

Renal expression and serum levels of high mobility group box 1 protein in lupus nephritis [PDF]

, 2012
INTRODUCTION: High mobility group box 1 protein (HMGB1) is a nuclear DNA binding protein acting as a pro-inflammatory mediator following extracellular release.
Agneta Zickert, Annette Bruchfeld, Birgitta Sundelin, Iva Gunnarsson, Karin Palmblad, Kevin J Tracey, Sangeeta Chavan   +6 more
core   +1 more source

The Roles of High Mobility Group Box 1 in Cerebral Ischemic Injury

Frontiers in Cellular Neuroscience, 2020
High mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that plays an important role in stabilizing nucleosomes and DNA repair. HMGB1 can be passively released from necrotic neurons or actively secreted by microglia, macrophages/monocytes, and ...
Xiaoyun Gou, Xiaoyun Gou, Junjie Ying, Junjie Ying, Yan Yue, Yan Yue, Xia Qiu, Xia Qiu, Peng Hu, Peng Hu, Yi Qu, Yi Qu, Jinhui Li, Jinhui Li, Dezhi Mu, Dezhi Mu   +15 more
doaj   +1 more source

Liver kinase B1 inhibits smooth muscle calcification via high mobility group box 1

Redox Biology, 2021
Vascular calcification is a common pathological feature of atherosclerosis, chronic kidney disease, vascular injury, and aging. Liver kinase B1 (LKB1) plays pivotal roles in cellular processes such as apoptosis, metabolism, and cell cycle regulation.
Tianran Zhang, Hongxuan Li, Changhan Ouyang, Guangqing Cao, Jiangang Gao, Jiliang Wu, Jianmin Yang, Nengwang Yu, Qing Min, Cheng Zhang, Wencheng Zhang   +10 more
doaj   +1 more source

High mobility group box 1 (HMGB1): a pivotal regulator of hematopoietic malignancies

Journal of Hematology & Oncology, 2020
High mobility group box 1 (HMGB1) is a nonhistone chromatin-associated protein that has been widely reported to play a pivotal role in the pathogenesis of hematopoietic malignancies.
Shunling Yuan, Zhaoping Liu, Zhenru Xu, Jing Liu, Ji Zhang   +4 more
doaj   +1 more source

NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance [PDF]

, 2019
Lack of proper innate sensing inside tumor microenvironment (TME) limits T cell-targeted immunotherapy. NAD(P)H:quinone oxidoreductase 1 (NQO1) is highly enriched in multiple tumor types and has emerged as a promising target for direct tumor-killing ...
Boothman, David A., Fu, Yang-Xin, Han, Chuanhui, Huang, Xiumei, Jiang, Lingxiang, Li, Xiaoguang, Liu, Zhida, Qiao, Jian, Shen, Aijun, Wang, Yang, Zhang, Anli   +10 more
core   +1 more source

High mobility group box 1 protein in the central nervous system

Journal of Medical Science, 2014
High-mobility group box 1 protein (HMGB1) is a multifunctional protein originally identified as a nuclear transcription modifier. Two pathways are leading to HMGB1 release to the extracellular space i.e.
Norbert Wąsik, Roman Jankowski, Bartosz Sokół, Hinna Shahid   +3 more
doaj   +1 more source

Gene Expression and Localization of High-mobility Group Box Chromosomal Protein-1 (HMGB-1) in Human Osteoarthritic Cartilage [PDF]

, 2011
We investigated the expression and localization of high-mobility group box chromosomal protein-1 (HMGB-1) in human osteoarthritic (OA) cartilage in relation to the histopathological grade of cartilage destruction, and examined the role of HMGB-1 in the ...
Mori, Shuji, Nasu, Yoshihisa, Nishibori, Masahiro, Nishida, Keiichiro, Ozaki, Toshifumi, Takahashi, Hideo K., Tanaka, Masato, Terada, Chuji, Tomono, Yasuko, Yoshida, Aki   +9 more
core   +1 more source

High-Mobility Group Box 1, Oxidative Stress, and Disease [PDF]

Antioxidants & Redox Signaling, 2011
Oxidative stress and associated reactive oxygen species can modify lipids, proteins, carbohydrates, and nucleic acids, and induce the mitochondrial permeability transition, providing a signal leading to the induction of autophagy, apoptosis, and necrosis.
Daolin, Tang, Rui, Kang, Herbert J, Zeh, Michael T, Lotze   +3 more
openaire   +2 more sources

Usefulness of High Mobility Group Box 1 Protein as a Plasma Biomarker in Patient with Peripheral Artery Disease [PDF]

, 2014
Atherosclerosis is often associated with chronic vascular inflammation. High-mobility group box 1 protein (HMGB1) plays various roles, not only as a transcriptional regulatory factor in the nucleus, but also as an inflammatory mediator.
Nishibori, Masahiro, Oozawa, Susumu, Sano, Shunji   +2 more
core   +1 more source