Results 71 to 80 of about 204,374 (297)

A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation [PDF]

, 2006
Cellular senescence is a stable state of proliferative arrest that provides a barrier to malignant transformation and contributes to the antitumor activity of certain chemotherapies.
Lowe, S. W., Myers, Michael P., Chicas, A., Narita, M., Hearn, S. A., Myers, M. P., Nuñez, Sabrina, Lowe, Scott W., Chicas, Agustin, Narita, Masako, Narita, Masashi, Krizhanovsky, V., Hearn, Stephen A., Nunez, S., Krizhanovsky, Valery   +14 more
core   +1 more source

HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche

Nature Communications, 2017
The function of high mobility group A1 (Hmga1) chromatin remodelling proteins in intestinal stem cells (ISC) is unknown. Here, the authors show that Hmga1 amplifies Wnt/β-catenin signalling to enhance self-renewal and inducesSox9to expand the Paneth cell
Lingling Xian, Dan Georgess, Tait Huso, Leslie Cope, Amy Belton, Yu-Ting Chang, Wenyong Kuang, Qihua Gu, Xiaoyan Zhang, Stefania Senger, Alessio Fasano, David L. Huso, Andrew J. Ewald, Linda M. S. Resar   +13 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Role of the high mobility group A proteins in the regulation of pituitary cell cycle. [PDF]

, 2010
Pituitary cells are particularly sensitive to alterations of the cell cycle machinery. In fact, mutations affecting expression of proteins critical for cell cycle progression, including retinoblastoma protein, cyclins D1 and D3, p16(INK4A), and p27(kip1),
FUSCO, ALFREDO, Fedele M.
core   +1 more source

Higher expression of high-mobility group box 1 in cholangiocarcinoma and association with cell growth, in vitro migration and invasion, and chemo-drug sensitivity

Science Progress
Objective Cholangiocarcinoma is a lethal malignancy with an increasing incidence and mortality worldwide. Numerous studies have indicated that high-mobility group box 1 is associated with cancer progression.
Arunya Jiraviriyakul, Samitanan Promchai, Chatchai Nensat, Suphakit Khutanthong, Nun Singpan, Worawat Songjang   +5 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Calcium-dependent ADP-ribosylation of high-mobility-group I (HMGI) proteins [PDF]

, 1996
Micrococcal nuclease digestion of nuclei from mouse Lewis lung carcinoma cells releases a protein mixture into the supernatant that lacks histone H1 and contains a full complement of high-mobility-group I (HMGI) proteins (i.e. I, Y and I-C). This implies
CRANE ROBINSON C., GIANCOTTI V, BANDIERA A, PERISSIN, Laura, SINDICI C   +4 more
core  

Unexpected mobility of plant chromatin-associated HMGB proteins [PDF]

, 2011
Merkle T, Grasser KD. Unexpected mobility of plant chromatin-associated HMGB proteins. Plant Signaling & Behavior. 2011;6(6):878-880.High mobility group (HMG) proteins of the HMGB family containing a highly conserved HMG box are chromatin-associated ...
Klaus D. Grasser, Grasser, Klaus D., Merkle, Thomas, Thomas Merkle   +3 more
core   +1 more source

HMGA2 directly mediates chromatin condensation in association with neuronal fate regulation

Nature Communications, 2023
Identification of factors that regulate chromatin condensation is important for understanding of gene regulation. High-mobility group AT-hook (HMGA) proteins 1 and 2 are abundant nonhistone chromatin proteins that play a role in many biological processes
Naohiro Kuwayama, Tomoya Kujirai, Yusuke Kishi, Rina Hirano, Kenta Echigoya, Lingyan Fang, Sugiko Watanabe, Mitsuyoshi Nakao, Yutaka Suzuki, Kei-ichiro Ishiguro, Hitoshi Kurumizaka, Yukiko Gotoh   +11 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source