Results 21 to 30 of about 235,335 (148)

Dihydromyricetin ameliorated nonalcoholic steatohepatitis in mice by regulating the composition of serous lipids, bile acids and ileal microflora

Lipids in Health and Disease, 2023
Background Dihydromyricetin (DMY) is a natural flavonoid with anti-nonalcoholic steatohepatitis (NASH) activity. However, the effects of DMY on the composition of lipids and bile acids (BAs) in serum, and gut microbiota (GM) in ileum of mice with NASH ...
Xiaolei Miao, Ping Luo, Jiao Liu, Junjun Wang, Yong Chen   +4 more
doaj   +1 more source

Screening for molecular glues – Challenges and opportunities

SLAS Discovery
Molecular glues are small molecules, typically smaller than PROTACs, and usually with improved physicochemical properties that aim to stabilise the interaction between two proteins.
Geoffrey A. Holdgate, Catherine Bardelle, Sophia K. Berry, Alice Lanne, Maria Emanuela Cuomo   +4 more
doaj   +1 more source

Genome-Wide siRNA Screen for Anti-Cancer Drug Resistance in Adherent Cell Lines

Bio-Protocol, 2015
The expression of genes is frequently manipulated in cell lines to study their cellular functions. The use of exogenous small Interfering RNAs (siRNAs) is a very efficient technique to temporarily downregulate the expression of genes of interest ...
Elza de Bruin, Ming Jiang, Michael Howell, Julian Downward   +3 more
doaj   +1 more source

A Searchable Database of Crystallization Cocktails in the PDB: Analyzing the Chemical Condition Space

Patterns, 2020
Summary: Nearly 90% of structural models in the Protein Data Bank (PDB), the central resource worldwide for three-dimensional structural information, are currently derived from macromolecular crystallography (MX).
Miranda L. Lynch, Max F. Dudek, Sarah E.J. Bowman   +2 more
doaj   +1 more source

Beneficial effects of silibinin on serum lipids, bile acids, and gut microbiota in methionine-choline-deficient diet-induced mice

Frontiers in Nutrition, 2023
Background and purposeSilibinin (SIL) is a flavonoid lignin isolated from the fruit and seeds of silybum marianum that exhibits good therapeutic potential for NASH. However, the effects of SIL on serum lipids, bile acids (BAs), and gut microbiota (GM) in
Wei Wang, Ting Zhai, Ping Luo, Xiaolei Miao, Junjun Wang, Yong Chen   +5 more
doaj   +1 more source

Breaking shackles of molecular weight and emission for NIR-II fluorophores by regulating Columb attraction interaction

Nature Communications
The second near-infrared (NIR-II) dyes provide advantages for in vivo imaging, but challenges persist. A primary issue is the lack of practicable strategies to balance emission wavelength and molecular weight, particularly for low-molecular-weight ( 1000 
Miantai Ye, Xiaoyu Wang, Jingwen Zou, Wei Sun, Weijie Chi, Zhiqiang Mao, Zhihong Liu   +6 more
doaj   +1 more source

The Expression and Prognostic Value of Cancer Stem Cell Markers, NRF2, and Its Target Genes in TAE/TACE-Treated Hepatocellular Carcinoma

Medicina, 2022
Background and Objectives: Activation of NRF2, a key transcription factor of cytoprotectant against oxidative stress, and its target genes are associated with aggressive tumor progression, metastasis and poor survival.
Duurenjargal Tseeleesuren, Hui-Hua Hsiao, Rajni Kant, Yu-Chuen Huang, Hung-Pin Tu, Chih-Chung Lai, Shiu-Feng Huang, Chia-Hung Yen   +7 more
doaj   +1 more source

Effects of novel microecologics combined with traditional Chinese medicine and probiotics on growth performance and health of broilers

Poultry Science, 2022
: In this study, we prepared a kind of novel microecologics, namely Chinese medicine–probiotic compound microecological preparation (CPCMP), which is composed of 5 traditional Chinese medicine herbs (Galla Chinensis, Andrographis paniculata, Arctii ...
Jin Gao, Rui Wang, Jingxuan Liu, Wenling Wang, Yong Chen, Wentao Cai   +5 more
doaj   +1 more source

A new vulnerability to BET inhibition due to enhanced autophagy in BRCA2 deficient pancreatic cancer

Cell Death and Disease, 2023
Pancreatic cancer is one of the deadliest diseases in human malignancies. Among total pancreatic cancer patients, ~10% of patients are categorized as familial pancreatic cancer (FPC) patients, carrying germline mutations of the genes involved in DNA ...
EunJung Lee, Suyakarn Archasappawat, Keely Ji, Jocelyn Pena, Virneliz Fernandez-Vega, Ritika Gangaraju, Nitin Sai Beesabathuni, Martin Jean Kim, Qi Tian, Priya S. Shah, Louis Scampavia, Timothy P. Spicer, Chang-Il Hwang   +12 more
doaj   +1 more source

Protective Effect of Arbidol Against Pulmonary Fibrosis and Sepsis in Mice

Frontiers in Pharmacology, 2021
From the perspective of epidemiology, viral immunology and current clinical research, pulmonary fibrosis may become one of the complications of patients with Coronavirus Disease 2019 (COVID-19).
Hailong Li, Hailong Li, Rui Liu, Rui Liu, Ruotong Zhang, Ruotong Zhang, Shanshan Zhang, Yiying Wei, Yiying Wei, Liang Zhang, Honggang Zhou, Honggang Zhou, Cheng Yang, Cheng Yang   +13 more
doaj   +1 more source