Results 21 to 30 of about 15,879,841 (288)

Codelivery of HBx-siRNA and Plasmid Encoding IL-12 for Inhibition of Hepatitis B Virus and Reactivation of Antiviral Immunity

Pharmaceutics, 2022
Chronic hepatitis B is a critical cause of many serious liver diseases such as hepatocellular carcinoma (HCC). The main challenges in hepatitis B treatment include the rebound of hepatitis B virus (HBV)-related antigen levels after drug withdrawal and ...
Yan Mu, Xiao-He Ren, Di Han, Ying-Ying Guan, Pei-Ling Liu, Si-Xue Cheng, Hong Liu   +6 more
doaj   +1 more source

EIF2S2 is a novel independent prognostic biomarker and correlated with immune infiltrates in hepatocellular carcinoma

Frontiers in Genetics, 2022
Background: Hepatocellular carcinoma (HCC) is a highly malignant disease with poor prognosis. It is urgent to find effective biomarkers. Eukaryotic Translation Initiation Factor 2 Subunit Beta (EIF2S2) is a subunit of heterotrimeric G protein EIF2, and ...
Jing Liu, Jing Liu, Tongyu Liu, Chuanhao Zhang, Chuanhao Zhang, Jiabei He, Jiabei He, Dong Zhou, Dong Zhou, Zhe Wang, Zhe Wang, Ruoyu Wang, Ruoyu Wang   +12 more
doaj   +1 more source

Machine learning assisted hit prioritization for high throughput screening in drug discovery [PDF]

, 2023
Efficient prioritization of bioactive compounds from high throughput screening campaigns is a fundamental challenge for accelerating drug development efforts.
Lukas, Friedrich, Daniel, Kuhn, Stephan, Sieber, Davide, Boldini   +3 more
core   +2 more sources

nrijs/Automated-Structural-Activity-Screening-of--Diketonate-Assemblies-with-High-Throughput-Ion-Mobility: v1.0

, 2023
Automated Structural Activity Screening of β-Diketonate Assemblies with High-Throughput Ion Mobility - Mass ...
OLWatUNSW
core   +1 more source

A high-throughput human tissue model for respiratory viruses: Automating the use of human airway epithelial tissues for faster drug discovery

SLAS Discovery
Animal testing for drug discovery is expensive and the decision to test a compound in an in vivo model should be carefully considered. In addition, the FDA Modernization Act has resulted in the allowance of alternatives to animal models for testing the ...
N. Miranda Nebane, Andrew Reece, Lynn Rasmussen, Melinda Sosa, Pedro Ruiz, Sara M. Cabrera, Yohanka Martinez-Gzegozewska, Paige Vinson   +7 more
doaj   +1 more source

Role of matrix metalloproteinases in diabetic foot ulcers: Potential therapeutic targets

Frontiers in Pharmacology, 2022
Diabetic foot ulcers (DFUs) are pathological states of tissue destruction of the foot or lower extremity in diabetic patients and are one of the serious chronic complications of diabetes mellitus.
Kang Fu, Xueyao Zheng, Yuhan Chen, Yuhan Chen, Liuying Wu, Liuying Wu, Zhiming Yang, Zhiming Yang, Xu Chen, Xu Chen, Wei Song, Wei Song   +11 more
doaj   +1 more source

High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase [PDF]

, 2011
<p><b>Background:</b> <i>Leishmania</i> species are parasitic protozoa that have a tightly controlled cell cycle, regulated by cyclin-dependent kinases (CDKs).
Mottram Jeremy C., Thomson, Graeme, Mottram, JC, Grant Karen M., Turner, N.J., Malcolm D. Walkinshaw, Malone, Kirk, Turner, Nicholas J., Nicholas J Turner, Jeremy C. Mottram, Karen M. Grant, Walker, Roderick G., Kita, K, Graeme Thomson, Malone Kirk, Karen M Grant, Grant, Karen, Nicholas J. Turner, Walker, RG, Nowicki, Matthew W., Thomson Graeme, Walkinshaw, M.D., Walkinshaw Malcolm D., David G. Blake, David G Blake, Walker Roderick G., Brown, Elaine, Brown Elaine, Blake David G., Brown, E, Malone, K, Turner Nicholas J., Walkinshaw, MD, Blake, DG, Matthew W. Nowicki, Walker, R.G., Malone, K., Blake, David G., Elaine Brown, Mottram, J.C., Kirk Malone, Walkinshaw, Malcolm D., Matthew W Nowicki, Nowicki, MW, Brown, E., Nowicki Matthew W., Turner, Nicholas J.; id_orcid, Grant, Karen M., Grant, K.M., Mottram, Jeremy C., Roderick G Walker, Thomson, G, Jeremy C Mottram, Roderick G. Walker, Nowicki, M.W., Grant, KM, Blake, D.G., Malcolm D Walkinshaw, Turner, NJ, Thomson, G.   +59 more
core   +2 more sources

Linking a role of lncRNAs (long non-coding RNAs) with insulin resistance, accelerated senescence, and inflammation in patients with type 2 diabetes

Human Genomics, 2018
Background Studying epigenetics is expected to provide precious information on how environmental factors contribute to type 2 diabetes mellitus (T2DM) at the genomic level.
Chandrakumar Sathishkumar, Paramasivam Prabu, Viswanathan Mohan, Muthuswamy Balasubramanyam   +3 more
doaj   +1 more source

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source

High-throughput chemical screening for antivirulence developmental phenotypes in Trypanosoma brucei. [PDF]

, 2014
In the bloodstream of mammalian hosts, the sleeping sickness parasite, Trypanosoma brucei, exists as a proliferative slender form or a nonproliferative, transmissible, stumpy form.
Auer, Manfred, Ivens, A, Matthews, KR, Matthews, Keith R., Collie, I, Ivens, Alasdair, Auer, M, Gray, David, McGregor, Paula, Macgregor, Paula, Matthews, Keith R; id_orcid, Gray, David; id_orcid, Collie, Iain, Shave, S, MacGregor, P, Gray, D, Shave, Steven   +16 more
core   +1 more source