Results 41 to 50 of about 235,335 (148)

Whole‑exome evolutionary profiling of osteosarcoma uncovers metastasis‑related driver mutations and generates an independently validated predictive classifier

Journal of Translational Medicine
Background Osteosarcoma is the most common primary malignant bone tumor, with high invasiveness and metastatic potential and a poor prognosis in patients with metastatic cancer. Despite the rapid advancements in genomics in recent years that provided new
Zhen Wang, Zhe Wang, Ruoyu Wang, Zumin Wang, Xiangyang Cao, Rui Chen, Zebing Ma, Shanshan Liang, Shuai Tao   +8 more
doaj   +1 more source

Novel PHL derivatives targeting quorum sensing: A strategy to combat Pseudomonas aeruginosa infections

Biofilm
Pseudomonas aeruginosa (P. aeruginosa) is a common pathogenic bacterium that is widely distributed and highly pathogenic. Its pathogenicity is closely related to the formation of biofilms and virulence factors.
Juanyan Liu, Yi Deng, Xinran Wang, Piao Luo, Shuaiwen Ding, Weizhong Zhang, Shahab Uddin, Hongyu Li, Yang Li   +8 more
doaj   +1 more source

Schisandrin B targets CDK4/6 to suppress proliferation and enhance radiosensitivity in nasopharyngeal carcinoma by inducing cell cycle arrest

Scientific Reports
Nasopharyngeal carcinoma (NPC) is notably prevalent in East and Southeast Asia, where despite advancements in radiotherapy leading to high control rates, challenges like radioresistance and collateral tissue damage remain significant. While Schisandrin B
Yanhua Fang, Xinhui Lv, Ge Li, Piao Wang, Lingling Zhang, Ruoyu Wang, Lingyun Jia, Shanshan Liang   +7 more
doaj   +1 more source

Models for calcific aortic valve disease in vivo and in vitro

Cell Regeneration
Calcific Aortic Valve Disease (CAVD) is prevalent among the elderly as the most common valvular heart disease. Currently, no pharmaceutical interventions can effectively reverse or prevent CAVD, making valve replacement the primary therapeutic recourse ...
Zijin Zhu, Zhirong Liu, Donghui Zhang, Li Li, Jianqiu Pei, Lin Cai   +5 more
doaj   +1 more source

A CRISPR platform for targeted in vivo screens identifies Toxoplasma gondii virulence factors in mice

Nature Communications, 2019
Targeted CRISPR libraries expand the use of genetic screens across experimental conditions. Here, the authors develop a method for generating and analysing small scale custom CRISPR libraries and use it in the human and livestock pathogen Toxoplasma ...
Joanna Young, Caia Dominicus, Jeanette Wagener, Simon Butterworth, Xingda Ye, Gavin Kelly, Merav Ordan, Becky Saunders, Rachael Instrell, Michael Howell, Aengus Stewart, Moritz Treeck   +11 more
doaj   +1 more source

Patient-derived organoid elucidates the identical clonal origin of bilateral breast cancer with diverse molecular subtypes

Frontiers in Oncology
Bilateral breast cancer (BBC), an infrequent breast cancer subtype, has primarily been studied in terms of incidence, prognosis, and through comparative analysis of synchronous (SBBC) and metachronous (MBBC) manifestations.
Zhongbin Han, Zhongbin Han, Liangxue Yao, Yanhua Fang, Sijing Chen, Sijing Chen, Ruiqing Lian, Yongqiang Yao, Hongsheng Chen, Xuening Ji, Weiting Yu, Zhe Wang, Ruoyu Wang, Ruoyu Wang, Shanshan Liang   +14 more
doaj   +1 more source

Hyperphosphorylated tau-based Alzheimer’s Disease drug discovery: Identification of inhibitors of tau aggregation and cytotoxicity

SLAS Discovery
Alzheimer’s disease (AD) is a neurodegenerative disorder that affects more than 30 million people worldwide. Underlying the progressive decline of cognitive functions are the neurofibrillary tangles (NFTs) in neurons of the brain.
Hsiao-Tien Hagar, Virneliz Fernandez-Vega, Kuang-Wei Wang, Luis M. Ortiz Jordan, Justin Shumate, Louis Scampavia, April Sweet Tapayan, Hien M Nguyen, Timothy P. Spicer, Min-Hao Kuo   +9 more
doaj   +1 more source

Targeting EMT using low-dose Teniposide by downregulating ZEB2-driven activation of RNA polymerase I in breast cancer

Cell Death and Disease
Metastatic dissemination from the primary tumor is a complex process that requires crosstalk between tumor cells and the surrounding milieu and involves the interplay between numerous cellular-signaling programs.
Brandon J. Metge, Heba Allah M. Alsheikh, Sarah C. Kammerud, Dongquan Chen, Devika Das, N. Miranda Nebane, J. Robert Bostwick, Lalita A. Shevde, Rajeev S. Samant   +8 more
doaj   +1 more source

StabLyzeGraph: High-throughput screening of combinatorial mutations using graph neural networks. [PDF]

Protein Sci
Waqas M, Natale B, Roggia M, Saha PP, Mileni M, Cosconati S.   +5 more
europepmc   +1 more source

Retraction Note: Polyphyllin I suppresses the formation of vasculogenic mimicry via Twist1/VE-cadherin pathway

Cell Death and Disease
Ting Xiao, Weilong Zhong, Jianmin Zhao, Baoxin Qian, Huijuan Liu, Shuang Chen, Kailiang Qiao, Yueyang Lei, Shumin Zong, Hongzhi Wang, Yuan Liang, Heng Zhang, Jing Meng, Honggang Zhou, Tao Sun, Yanrong Liu, Cheng Yang   +16 more
doaj   +1 more source