Results 71 to 80 of about 67,791 (260)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Toward a science-based classification of processed foods to support meaningful research and effective health policies

Frontiers in Nutrition
Processed foods have been part of the American diet for decades, with key roles in providing a safe, available, affordable, and nutritious food supply.
Paula R. Trumbo, Paula R. Trumbo, Rachel Bleiweiss-Sande, Jessica K. Campbell, Eric Decker, Adam Drewnowski, John W. Erdman, Mario G. Ferruzzi, Ciaran G. Forde, Michael J. Gibney, Julie M. Hess, David M. Klurfeld, Marie E. Latulippe, Lauren E. O’Connor, Kristin J. Reimers, Barbara J. Rolls, Jackie Schulz, Connie Weaver, Lynn Yu   +18 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Food Technologies and Developing Countries: A Processing Method for Making Edible the Highly Toxic Cassava Roots

Italian Journal of Agronomy, 2014
In addition to be a possible solution to the food crisis becoming a productive model to follow, the development of a process and/or a technique of food production in a developing country could create advantages from an industrial point of view due to the use of alternative raw materials, which have a potentially high competitiveness.
Lambri, Milena, Fumi, Maria Daria
openaire   +5 more sources

The role of mediterranean diet and highly processed foods in inflammatory bowel diseases

Digestive and Liver Disease
The Mediterranean Diet (MD) is considered a balanced dietary model, whereas high consumption of highly processed foods (HPF) may worsen metabolic health. We aimed to compare adherence to the MD and HPF consumption between patients with Crohn's Disease (CD) and Ulcerative Colitis (UC), and to assess their relationship with disease activity.
D. Maniero, N. Pol, C. Caranfil, N. Capuani, G. Romanelli, A. Schiepatti, B. Barberio, E.V. Savarino, F. Zingone   +8 more
openaire   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Has the two decades of research on the gut microbiome resulted in making healthier choices?

Gut Microbiome
The gut microbiome is widely recognized for its significant contribution to maintaining human health across all life stages, from infancy to adulthood and beyond.
M. Andrea Azcarate-Peril
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

One size does not fit all: Understanding the five stages of ultra-processed food addiction

Journal of Metabolic Health
In recent years, research has demonstrated that ultra-processed foods are highly addictive. However, there has been limited discussion on the clinical syndrome of food addiction, and how exposure to addictive foods can result in a chronic progressive ...
Vera I. Tarman
doaj   +1 more source