Results 61 to 70 of about 5,403 (145)

Energetic stress in combination with impaired fatty acid oxidation induces sequestration of CoA and adaptation of CoA metabolism

The FEBS Journal, Volume 293, Issue 12, Page 3565-3587, June 2026.
Computational modelling and in vitro liver cell experiments indicate that medium‐chain acyl‐CoA dehydrogenase (MCAD) deficiency causes an accumulation of (especially medium‐chain) acyl‐CoAs at the cost of free CoA (CoASH). A substantial decrease in CoASH impairs flux through many pathways essential for energy homeostasis.
Ligia Akemi Kiyuna, Christoff Odendaal, Madhulika Singh, Albert Gerding, Miriam Langelaar‐Makkinje, Marianne van der Zwaag, Asmara Drachman, Vladimíra Cetkovská, Gaby Liem Foeng Kioen, Anne‐Claire M. F. Martines, Nicolette C. A. Huijkman, Hein Schepers, Bart van de Sluis, Dirk‐Jan Reijngoud, Ody C. M. Sibon, Amy C. Harms, Thomas Hankemeier, Barbara M. Bakker   +17 more
wiley   +1 more source

Dilute and Shoot: A novel approach for determination of chlormequat and mepiquat in beer

Kvasný průmysl
The extensive use of pesticides in agriculture has led to the presence of their residues in soil, water sources, and crops. Among these, the plant growth regulators chlormequat and mepiquat are commonly employed to regulate plant growth.
Marek Pernica, Jan Martiník, Simona Černá, Zdeněk Svoboda, Karolína Benešová, Rastislav Boško, Sylvie Běláková   +6 more
doaj   +1 more source

Temporal Metabolomics Profiling Reveals Liver Metabolic Control in Single and Repeated Exhaustive Exercise in Murine Models

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
Temporal metabolomics profiling reveals divergent liver recovery trajectories between single and repeated exhausted exercise stress. Single exhaustive exercise (SEE) demonstrates transient metabolic perturbations resolving within 24 h. In contrast, repeated exhaustive exercise (REE) triggers sustained metabolic remodeling that persists beyond the ...
Jining Yang, Dawei Wang, Hui Shen, Yundong Xia, Hedong Lang, Wenxin Zhou, Long Yi, Mantian Mi   +7 more
wiley   +1 more source

Farmacocinética comparada de metformina, en forma sólida y en formulación extemporánea líquida para pediatría, en voluntarios adultos sanos

Acta Pediátrica de México, 2016
ANTECEDENTES: fraccionar o pulverizar tabletas de metformina para ajustar dosis pediátricas dificulta su administración, genera inestabilidad del fármaco (oxidación/fotosensibilidad) y relativiza su biodisponibilidad.
L Rivera-Espinosa, G Pérez-Guillé, JL Chávez-Pacheco, LM Torres-Espíndola, H Juárez-Olguín, R Alemón-Medina   +5 more
doaj   +1 more source

Usporedba metoda mikrouzorkovanja krvi za analizu N-glikanskog profila plazme metodom HILIC-UPLC

, 2021
Glikozilacija proteina najraznovrsnija je posttranslacijska modifikacija proteina, a N-glikozilacija najčešća je i najbolje proučena vrsta glikozilacije. Jasna je korelacija između N-glikanskog profila proteina plazme i brojnih patoloških stanja, naročito onih sa značajnom upalnom komponentom, što je analizu glikanskog profila proteina plazme učinilo ...
openaire   +1 more source

N‐glycan signatures identified in tumor interstitial fluid and serum of breast cancer patients: association with tumor biology and clinical outcome

Molecular Oncology, 2018
Particular N‐glycan structures are known to be associated with breast malignancies by coordinating various regulatory events within the tumor and corresponding microenvironment, thus implying that N‐glycan patterns may be used for cancer stratification ...
Thilde Terkelsen, Vilde D. Haakensen, Radka Saldova, Pavel Gromov, Merete Kjær Hansen, Henning Stöckmann, Ole Christian Lingjærde, Anne‐Lise Børresen‐Dale, Elena Papaleo, Åslaug Helland, Pauline M. Rudd, Irina Gromova   +11 more
doaj   +1 more source

Galactose tolerance in adults with classical galactosaemia. Considering the gaps

Molecular Genetics and Metabolism Reports
Classical galactosaemia (CG, OMIM 230400) is a rare inborn error of metabolism caused by deficiency of galactose-1-phosphate uridylyltransferase.
L.A. Shakerdi, C. Newman Thacker, K. Moore, A. Sheerin, M. Noga, M.E. Rubio-Gozalbo, G.T. Berry, J.J. O'Byrne, R. Saldova, E.P. Treacy   +9 more
doaj   +1 more source

Immunoglobulin G N-glycosylation predicts outcome in sepsis caused by pathogenic Gram-negative bacteria and Gram-positive bacteria: a nested case-control study

Frontiers in Immunology
BackgroundSepsis remains a critical global health challenge with high mortality. Rapid distinction between Gram-positive and Gram-negative pathogens is critical for empiric antibiotic selection, yet reliable biomarkers for such pathogen stratification ...
Huachen Wang, Huachen Wang, Yan Zhang, Anlu Ouyang, Tao Wang, Hongda Hou, Hongda Hou, Haifeng Hou, Bing Chen, Bing Chen   +9 more
doaj   +1 more source

The association between plasma IgG N-glycosylation and viral encephalitis in children: a hospital-based case-control study

Italian Journal of Pediatrics
Background Viral encephalitis (VE) is an acute inflammatory disease caused by viral infection. Children are at a significantly higher risk of developing VE than adults.
Yan Zhang, Zi Lin, Hui Niu, Yinghao Wang, Xiangqian Jin, Lihua Tang, Haifeng Hou, Cancan Li   +7 more
doaj   +1 more source

Strukturna analiza N-glikanskog profila staničnih linija HepG2 i 1.1B4 HILIC-UPLCFLR-MS/MS metodom [PDF]

, 2019
Glycosylation is the most common and complex modification of proteins and as such has a key role in shaping the final properties and functions of glycoproteins. Since glycan synthesis is not template-driven, but is instead strongly affected by environmental factors and pathophysiological processes, the diagnostic potential of glycans is being ...
openaire   +2 more sources