Results 71 to 80 of about 99,672 (347)

Exenatide Improves Bone Quality in a Murine Model of Genetically Inherited Type 2 Diabetes Mellitus [PDF]

, 2017
Type 2 diabetes mellitus (T2DM) is associated with skeletal complications, including an increased risk of fractures. Reduced blood supply and bone strength may contribute to this skeletal fragility.
Andreozzi, Anetzberger, Anichini, Aoyama, Baggio, Balint, Ban, Beckman, Bouxsein, Brunton, Chen, Coleman, Dempster, Ealey, Eckel, Feng, Flatt, Friedman, Griffith, Griffith, Hamilton, Hu, Karim, Kim, Lee, Lu, Ma, Mabilleau, Mabilleau, Mansur, Marenzana, Mieczkowska, Napoli, Nuche-Berenguer, Nuche-Berenguer, Nuche-Berenguer, Nystrom, Nystrom, Odgaard, Okerson, Orland, Orriss, Paschalis, Pereira, Pereira, Prisby, Richard, Roche, Roszer, Schalkwijk, Scheller, Selley, Shymkiw, Smits, Stabley, Sun, Tartaglia, Upadhyay, van Bloemendaal, Vijan, Williams, Wu, Yamamoto, Yamamoto, Yamamoto   +64 more
core   +4 more sources

Pulsatility Index as a Novel Parameter for Perfusion in Mouse Model of Hindlimb Ischemia

Cellular Physiology and Biochemistry, 2018
Background/Aims: In clinical settings, the pulsatility index (PI) has become a widely used tool for monitoring obstetrics or other vascular diseases. It is based on the maximum Doppler shift waveform derived from ultrasonography.
Hairong Xu, Shan Lu, Lexi Ding, Liangkun Lyu, Zejun Ma, Qiulun Lu   +5 more
doaj   +1 more source

Time‐Controlled Dual Targeting to Program Systemic and Intercellular Transfer of Therapeutic Effects

Advanced Functional Materials, EarlyView.
Aspirin‐liposomes loaded onto monocytes enable inflammation‐triggered targeting and efficient hand‐over of aspirin to inflamed cells. Monocytes uptake a significant portion of aspirin‐liposomes, prolonging therapeutic action. This approach enhances anti‐inflammatory effects through intercellular transfer, demonstrating a translational strategy for ...
Seung Eun Yu, Jueun Kim, Dae‐Hyun Kim, Sewoom Baek, Suji Park, Seyong Chung, Hak‐Joon Sung   +6 more
wiley   +1 more source

Systemic delivery of miR-126 by miRNA-loaded Bubble liposomes for the treatment of hindlimb ischemia

Scientific Reports, 2014
Currently, micro RNA (miRNA) is considered an attractive target for therapeutic intervention. A significant obstacle to the miRNA-based treatments is the efficient delivery of miRNA to the target tissue.
Y. Endo-Takahashi, Y. Negishi, Arisa Nakamura, Saori Ukai, Kotomi Ooaku, Y. Oda, K. Sugimoto, F. Moriyasu, N. Takagi, R. Suzuki, K. Maruyama, Y. Aramaki   +11 more
semanticscholar   +1 more source

Cortical AAV-CNTF gene therapy combined with intraspinal mesenchymal precursor cell transplantation promotes functional and morphological outcomes after spinal cord injury in adult rats [PDF]

, 2018
Ciliary neurotrophic factor (CNTF) promotes survival and enhances long-distance regeneration of injured axons in parts of the adult CNS. Here we tested whether CNTF gene therapy targeting corticospinal neurons (CSN) in motor-related regions of the ...
Akinpelu, Emmanuel A, Baron-Heeris, Danii, Duce, Emma, Fehily, Brooke, Fogliani, Alysia, Harvey, Alan R, Hodgetts, Stuart I, Houwers, Imke G.J, Lovett, Sarah J, Majda, Bernadette T, Pollett, Margaret A, Santhakumar, Sreya, Wheeler, Lachlan P.G, Wiseman, Tylie M, Yoon, Jun Han   +14 more
core   +3 more sources

Upconversion Nanoparticle‐Covalent Organic Framework Core–shell Particles as Therapeutic Microrobots Trackable With Optoacoustic Imaging

Advanced Materials, EarlyView.
Upconversion nanoparticle‐covalent organic framework core–shell particles provide enhanced contrast for optoacoustic imaging by leveraging the optical absorption of upconversion luminescence within the covalent organic framework matrix. Beyond their role as contrast agents, these particles enable customizable therapeutic agent loading and release, as ...
Dong Wook Kim, Paul Wrede, Andrés Rodríguez‐Camargo, Yi Chen, Nihal Olcay Dogan, Chaim Glück, Bettina V. Lotsch, Daniel Razansky, Metin Sitti   +8 more
wiley   +1 more source

Age-related deficits in skeletal muscle recovery following disuse are associated with neuromuscular junction instability and ER stress, not impaired protein synthesis. [PDF]

, 2016
Age-related loss of muscle mass and strength can be accelerated by impaired recovery of muscle mass following a transient atrophic stimulus. The aim of this study was to identify the mechanisms underlying the attenuated recovery of muscle mass and ...
Baar, Keith, Baehr, Leslie M, Bodine, Sue C, De Sousa, Luis Gustavo, Marcotte, George, Marshall, Andrea G, West, Daniel WD   +6 more
core   +2 more sources

Region-Dependent Increase of Cerebral Blood Flow During Electrically Induced Contraction of the Hindlimbs in Rats

Frontiers in Physiology, 2022
Elevation of cerebral blood flow (CBF) may contribute to the cerebral benefits of the regular practice of physical exercise. Surprisingly, while electrically induced contraction of a large muscular mass is a potential substitute for physical exercise to ...
Remi Chaney, Philippe Garnier, Philippe Garnier, Aurore Quirié, Alain Martin, Anne Prigent-Tessier, Christine Marie   +6 more
doaj   +1 more source

Flexible 3D Kirigami Probes for In Vitro and In Vivo Neural Applications

Advanced Materials, EarlyView.
A customizable and scalable approach to fabricate flexible 3D kirigami microelectrode arrays (MEAs) featuring up to 128 shanks, including surface and penetrating electrodes designed to interact with the 3D space of neural tissue, is presented. The 3D kirigami MEAs are successfully deployed in several neural applications, both in vitro and in vivo, and ...
Marie Jung, Jamal Abu Shihada, Simon Decke, Lina Koschinski, Peter Severin Graff, Sebastián Maruri Pazmino, Anke Höllig, Henner Koch, Simon Musall, Andreas Offenhäusser, Viviana Rincón Montes   +10 more
wiley   +1 more source

Take-off mechanics in hummingbirds (Trochilidae) [PDF]

, 2004
Initiating flight is challenging, and considerable effort has focused on understanding the energetics and aerodynamics of take-off for both machines and animals.
Altshuler, Douglas L., Powers, Donald R., Tobalske, Bret W.   +2 more
core   +2 more sources