Results 11 to 20 of about 5,385 (167)

Modeling of Chemoperfusion vs. Intravenous Administration of Cisplatin in Wistar Rats: Adsorption and Tissue Distribution

Molecules, 2020
Hyperthermic intraperitoneal chemoperfusion (HIPEC) is an established form of locoregional chemotherapy of peritoneum tumors. However, its efficacy and safety status remain a controversy, partially, due to scarce data on pharmacokinetics and toxicity ...
Galina Kireeva, Stepan Kruglov, Mikhail Maydin, Ekaterina Gubareva, Elena Fedoros, Ekaterina Zubakina, Natalya Ivanenko, Marina Bezruchko, Nikolay Solovyev   +8 more
doaj   +1 more source

The Global End-Diastolic Volume (GEDV) Could Be More Appropiate to Fluid Management Than Central Venous Pressure (CVP) During Closed Hyperthermic Intrabdominal Chemotherapy with CO2 Circulation

Journal of Investigative Surgery, 2018
Background: Closed hyperthermic intraperitoneal chemotherapy (HIPEC) may increase abdominal pressure and effects of hemodynamic changes due to maintenance hyperthermia.
Francisco Javier Redondo, David Padilla, Pedro Villarejo, Victor Baladron, Patricia Faba, Sergio Sánchez, José Ramón Muñoz-Rodríguez, Natalia Bejarano   +7 more
doaj   +1 more source

Assessment of Hyperthermic Intraperitoneal Chemotherapy to Eradicate Intraperitoneal Free Cancer Cells

Translational Oncology, 2016
OBJECTIVE: To assess the effect of hyperthermic intraperitoneal chemotherapy (HIPEC) to eradicate intraperitoneal free cancer cells and to explore the feasibility of cytological cure for peritoneal carcinomatosis (PC).
Zhonghe Ji, Jianhua Sun, Haitao Wu, Qian Zhang, Kaiwen Peng, Yan Li   +5 more
doaj   +1 more source

The prognosis impact of hyperthermic intraperitoneal chemotherapy (HIPEC) plus cytoreductive surgery (CRS) in advanced ovarian cancer: the meta-analysis

Journal of Ovarian Research, 2019
Background and objective Previous studies about the prognostic value of the HIPEC have yielded controversial results. Therefore, this study aims to assess the impact of HIPEC on patients with ovarian cancer.
Guyu Zhang, Yimin Zhu, Chongdong Liu, Guangming Chao, Ran Cui, Zhenyu Zhang   +5 more
doaj   +1 more source

Cytoreductive HIPEC-Combined Surgery in Treatment of Advanced Ovarian Cancer

Креативная хирургия и онкология, 2022
Background. Ovarian cancer ranks 5th in the structure of female oncological mortality in the Russian Federation, with a first-year post-diagnosis rate of almost 35%. In 75% cases, ovarian cancer is diagnosed at stages III—IV.
M. V. Zabelin, A. S. Safonov, N. V. Kuznetsov   +2 more
doaj   +1 more source

Readmissions after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy—a national population-based study

World Journal of Surgical Oncology, 2020
Background Comprehensive readmission morbidity studies after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are scarce. This study aimed to investigate readmissions and in-hospital morbidity after CRS and HIPEC. Methods
Paul Dranichnikov, Wilhelm Graf, Peter H. Cashin   +2 more
doaj   +1 more source

Risk factors of acute renal impairment after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

International Journal of Hyperthermia, 2020
Background Acute renal impairment (ARI) is a major complication after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) for cancer patients with peritoneal metastases.
Chao-Yu Chen, Hung-Yu Chang, Chang-Hsien Lu, Min-Chi Chen, Tzu-Hao Huang, Li-Wen Lee, Yu-San Liao, Vincent Chin-Hung Chen, Wen-Shih Huang, Yu-Che Ou, Feng-Chi Lung, Ting-Yao Wang   +11 more
doaj   +1 more source

A Retrospective Observational Study of Hyperthermic Intraperitoneal Chemotherapy for Gastric Cancer and Colorectal Cancer From a Single Center in the Recent 5 years

Cancer Control
Objective To retrospectively analyze the effect of hyperthermic intraperitoneal chemotherapy (HIPEC) on the progression free survival (PFS) of advanced gastric cancer (GC) and colorectal cancer (CRC).
Miao He, Xiao-dong Li, Zi-wei Wang, Hao Sun, Jing Fan   +4 more
doaj   +1 more source

A human ex vivo coculture model to investigate peritoneal metastasis and innovative treatment options

Pleura and Peritoneum, 2021
Peritoneal metastasis (PM) is commonly observed in patients with colorectal cancer (CRC). The outcome of these patients is poor, with an average survival of only six months without therapy, which requires a better understanding of PM biology and new ...
Mönch Dina, Koch Jana, Maaß Annika, Janssen Nicole, Mürdter Thomas, Renner Philipp, Fallier-Becker Petra, Solaß Wiebke, Schwab Matthias, Dahlke Marc-H., Schlitt Hans J., Leibold Tobias   +11 more
doaj   +1 more source

In Vivo CRISPR Screening Identifies the Glutamate Receptor GRIA2 as Promoting Peritoneal Metastasis of Gastric Cancer via Calcium‐Dependent β‐Catenin Activation

Advanced Science, EarlyView.
We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun, Xu Yang, Wenchao Jiang, Chengbo Ji, Yingying Wu, Haoyu Sun, Xinyou Liu, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Junjie Zhao, Yuanyuan Ruan, Haojie Li, Xuefei Wang   +13 more
wiley   +1 more source