The Hippo Pathway and Viral Infections
Frontiers in Microbiology, 2020 The Hippo signaling pathway is a novel tumor suppressor pathway, initially found in Drosophila. Recent studies have discovered that the Hippo signaling pathway plays a critical role in a wide range of biological processes, including organ size control ...
Zhilong Wang +5 more
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Hippo signaling impairs alveolar epithelial regeneration in pulmonary fibrosis
eLife, 2023 Idiopathic pulmonary fibrosis (IPF) consists of fibrotic alveolar remodeling and progressive loss of pulmonary function. Genetic and experimental evidence indicates that chronic alveolar injury and failure to properly repair the respiratory epithelium ...
Rachel Warren +3 more
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Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8+ T cell [PDF]
, 2012 During the primary response, the commitment of the CD8(+) T cell to Blimp-1 expression and the terminal differentiation that Blimp-1 induces must be timed so as not to impair the process of clonal expansion. We determined whether the Hippo pathway, which
A. Hoffmann +42 more
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Role of yes-associated protein in resistance of HER2+ breast cancer to lapatinib
Di-san junyi daxue xuebao, 2020 Objective To construct a lapatinib-resistant breast cancer cell line, and to study the role and underlying mechanism of yes-associated protein (YAP) in Hippo signaling pathway in the process.
CHEN Peng, XU Ting, GUO Dan, HUANG Jiayi
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SARS-CoV-2 Infection in Captive Hippos (Hippopotamus amphibius), Belgium
Animals, 2023 Two adult female hippos in Zoo Antwerp who were naturally infected with SARS-CoV-2 showed nasal discharge for a few days. Virus was detected by immunocytochemistry and PCR in nasal swab samples and by PCR in faeces and pool water.
Francis Vercammen +14 more
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The Role of RASSF5 on Cell Growth and Hippo Signaling in Rhabdomyosarcoma [PDF]
, 2020 Introduction: Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood. Dysregulation of the Hippo pathway, a signaling cascade that regulates many biological processes, is associated with many human cancers.
Garver, Megan +2 more
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Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease [PDF]
, 2016 Previous studies showed that YAP1 is over-expressed in hepatocellular carcinoma (HCC). Here we observed higher expression of Yap1/Ctgf axis in dysplastic nodules and HCC chemically-induced in F344 rats, genetically susceptible to hepatocarcinogenesis ...
Avila, Matias A. +13 more
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Mechanisms of YAP/TAZ transcriptional control
Cell Stress, 2021 Dysregulated gene expression is intrinsic to cell transformation, tumorigenesis and metastasis. Cancer-specific gene-expression profiles stem from gene regulatory networks fueled by genetic and epigenetic defects, and by abnormal signals of the tumor ...
Giusy Battilana +2 more
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Heartbreak hotel: a convergence in cardiac regeneration [PDF]
, 2016 In February 2016, the Company of Biologists hosted an intimate gathering of leading international researchers at the forefront of experimental cardiovascular regeneration, with its emphasis on ‘Transdifferentiation and Tissue Plasticity in Cardiovascular
Schneider, MD
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Systematic analysis of the Hippo pathway organization and oncogenic alteration in evolution. [PDF]
, 2020 The Hippo pathway is a central regulator of organ size and a key tumor suppressor via coordinating cell proliferation and death. Initially discovered in Drosophila, the Hippo pathway has been implicated as an evolutionarily conserved pathway in mammals ...
Chen, Yuxuan +7 more
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