Mood Disorder Severity and Subtype Classification Using Multimodal Deep Neural Network Models
SensorsThe subtype diagnosis and severity classification of mood disorder have been made through the judgment of verified assistance tools and psychiatrists.
Joo Hun Yoo +3 more
doaj +1 more source
Increased expression of YAP1 in prostate cancer correlates with extraprostatic extension. [PDF]
, 2017 Objective:Yes associated protein 1 (YAP1) is a member of the Hippo pathway, acting as a transcriptional coactivator. To elucidate the role of YAP1 and phosphorylated (p)YAP1 in prostate cancer (PCa) tumorigenesis, we investigated their expression in ...
Collak, Filiz Kisaayak +4 more
core
Rhabdomyosarcoma: Advances in Molecular and Cellular Biology. [PDF]
, 2015 Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in childhood and adolescence. The two major histological subtypes of RMS are alveolar RMS, driven by the fusion protein PAX3-FKHR or PAX7-FKHR, and embryonic RMS, which is usually ...
Duan, Zhenfeng +5 more
core +3 more sources
How to Train Your HiPPO: State Space Models with Generalized Orthogonal Basis Projections [PDF]
, 2022 Albert Gu +4 more
openalex +1 more source
Advanced Healthcare Materials, EarlyView.Here, we present a novel 3D cell patterning and culture platform. The “Floor‐Ceiling‐Chip” (FC‐Chip) consists of two opposing track‐etched membranes, creating a pseudo‐3D microenvironment for the cells in between. By providing the membranes with micropatterned cell‐adhesive islands of varying geometries and sizes, the FC‐Chip enables control over cell ...
Urandelger Tuvshindorj +10 more
wiley +1 more source
YAP and the Hippo pathway in pediatric cancer
Molecular & Cellular Oncology, 2017 The Hippo pathway is an important signaling pathway that controls cell proliferation and apoptosis. It is evolutionarily conserved in mammals and is stimulated by cell–cell contact, inhibiting cell proliferation in response to increased cell density ...
Atif A. Ahmed +4 more
doaj +1 more source
Functional interplay between the Hippo pathway and heavy metals
Molecular & Cellular Oncology, 2022 Emerging studies highlight the Hippo pathway as an important player in organ size control, tissue homeostasis, regeneration, development, and diseases, but our understanding of its roles and regulations remains incomplete.
Han Han +3 more
doaj +1 more source
Central role of Yes-associated protein and WW-domain-containing transcriptional co-activator with PDZ-binding motif in pancreatic cancer development. [PDF]
, 2019 Pancreatic ductal adenocarcinoma (PDAC) remains a deadly disease with no efficacious treatment options. PDAC incidence is projected to increase, which may be caused at least partially by the obesity epidemic.
Eibl, Guido, Rozengurt, Enrique
core
Lipophilic statins inhibit YAP nuclear localization, co-activator activity and colony formation in pancreatic cancer cells and prevent the initial stages of pancreatic ductal adenocarcinoma in KrasG12D mice. [PDF]
, 2019 We examined the impact of statins on Yes-associated Protein (YAP) localization, phosphorylation and transcriptional activity in human and mouse pancreatic ductal adenocarcinoma (PDAC) cells.
Chang, Hui-Hua +7 more
core +2 more sources
Taming the Hippo: Raf-1 Controls Apoptosis by Suppressing MST2/Hippo [PDF]
Cell Cycle, 2005 The Raf-1 kinase has a well established role in activating the MEK-ERK/MAPK pathway. However, accumulating evidence including the phenotype of Raf-1(-/-) mice suggested that Raf-1 may have other functions independent of its role as MEK activator, in particular pertaining to protection against apoptosis. We have recently demonstrated a new role of Raf-1
Eric, O'Neill, Walter, Kolch
openaire +2 more sources