Results 261 to 270 of about 60,559 (303)

The Role of Hippo Signaling in Brain Arteriovenous Malformations: Molecular Insights into Post-Embolization Remodeling. [PDF]

Int J Mol Sci
Neyazi B, Swiatek VM, Karimpour MA, Stassen S, Stein KP, Rashidi A, Dumitru CA, Sandalcioglu IE.   +7 more
europepmc   +1 more source

Non-coding RNAs and Hippo signaling in non-small cell lung cancer: emerging roles as biomarkers and therapeutic targets. [PDF]

Discov Oncol
Joulani M, Aghajamal N, Nouri M, Khajeh FR, Sharifi N, Saghafi D, Amiri M, Abdollahzadeh A, Heidari E, Mirdamadian A, Sharafi M, Masoumi S, Morovatshoar R, Azani A, Behfar Q.   +14 more
europepmc   +1 more source

Interpreting regulatory mechanisms of Hippo signaling through a deep learning sequence model. [PDF]

Cell Genom
Dalal K, McAnany C, Weilert M, McKinney MC, Krueger S, Zeitlinger J.   +5 more
europepmc   +1 more source

PTH counteracts Hippo signaling via Src-dependent YAP stabilization to enhance bone marrow stromal cell differentiation. [PDF]

JCI Insight
Monaci S, Wu M, Okada H, Mesil K, Keum BR, Monseff Rodrigues da Silva M, Rosen CJ, Gori F, Baron R.   +8 more
europepmc   +1 more source

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Hippo signalling directs intestinal fate

Nature Cell Biology, 2014
Hippo signalling has been associated with many important tissue functions including the regulation of organ size. In the intestinal epithelium differing functions have been proposed for the effectors of Hippo signalling, YAP and TAZ1. These are now shown to have a dual role in the intestinal epithelium, regulating both stem cell proliferation and ...
le Bouteiller, Marie Catherine M, Jensen, Kim Bak   +1 more
openaire   +3 more sources

KIBRA connects Hippo signaling and cancer

Experimental Cell Research, 2021
The Hippo signaling pathway is a tumor suppressor pathway that plays an important role in tissue homeostasis and organ size control. KIBRA is one of the many upstream regulators of the Hippo pathway. It functions as a tumor suppressor by positively regulating the core Hippo kinase cascade. However, there are accumulating shreds of evidence showing that
Srikanth Swamy Swaroop B, Rahul Kanumuri, Inemai Ezhil, Jagadeesh Kumar Naidu Sampangi, Joachim Kremerskothen, Suresh Kumar Rayala, Ganesh Venkatraman   +6 more
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Hippo signaling in regeneration and aging

Mechanisms of Ageing and Development, 2020
The two transcriptional coactivators YAP/TAZ act as the downstream transducers of the Hippo pathway. Recent studies have demonstrated that those two transcriptional regulators are crucial for an organism in order to induce a regenerative response upon tissue damage.
Dana, Elster, Björn, von Eyss
openaire   +2 more sources

Hippo signaling in mammalian stem cells

Seminars in Cell & Developmental Biology, 2012
Over the past decade, the Hippo signaling cascade has been linked to organ size regulation in mammals. Indeed, modulation of the Hippo pathway can have potent effects on cellular proliferation and/or apoptosis and a deregulation of the pathway often leads to tumor development. Importantly, emerging evidence indicates that the Hippo pathway can modulate
Annie M, Tremblay, Fernando D, Camargo
openaire   +2 more sources

Modularity in the Hippo signaling pathway

Trends in Biochemical Sciences, 2010
Metazoans have evolved several pathways to regulate the size of organs and ultimately that of organisms. One such pathway is known as Salvador-Warts-Hippo, or simply Hippo. Research on the Hippo pathway has grown exponentially during the past 8 years, revealing a complex signaling network.
Marius, Sudol, Kieran F, Harvey
openaire   +2 more sources