Results 271 to 280 of about 60,559 (303)
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Lipids Influence Hippo Signaling
Science Signaling, 2011A phosphatidylinositol 4-kinase is required for proper Merlin localization and Hippo signaling during fly oocyte polarization.
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Science Signaling, 2013
Protein kinase A represses activity of the transcriptional coactivator YAP.
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Protein kinase A represses activity of the transcriptional coactivator YAP.
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Hippo Signaling in the Immune System
Trends in Biochemical Sciences, 2018Hippo signaling has a pivotal role in organ size control, tissue regeneration, and cancer. Recent studies have demonstrated critical functions of Hippo signaling in cancer immunity, innate immune responses against pathogens, and autoimmune diseases, refreshing our understanding of the implications of this pathway in the context of disease and therapy ...
Yuchao, Zhang, Haitao, Zhang, Bin, Zhao
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Science Signaling, 2015
Hypoxia suppresses the Hippo pathway, reinforcing the stabilization of HIF-1α under low oxygen conditions.
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Hypoxia suppresses the Hippo pathway, reinforcing the stabilization of HIF-1α under low oxygen conditions.
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Reconstructing the Hippo signaling network
Science Bulletin, 2023Zhenxing, Zhong +2 more
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Altered Hippo signalling in polycystic kidney disease
The Journal of Pathology, 2011AbstractAutosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive deterioration of renal function and formation of cysts, and is an important cause of end‐stage renal disease. Previously we showed that tubular epithelial injury accelerates cyst formation in inducible Pkd1‐deletion mice. In these mice, expression of the planar
Happe, H. +6 more
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Hippo Signaling in Heart Development
2013Although much has been learned about heart development, it is surprising that very little is known about how heart size is regulated. Recent work in mice revealed that Hippo signaling interacts with canonical Wnt/β-catenin signaling to regulate cardiac organ size during fetal development.
Todd Heallen +5 more
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Hippo Signaling and Stem Cells
2013The normal growth and development of an organ is dependent on the precise balance of stem cell self-renewal and differentiation. Slightest aberrations in signals stem cells receive can cause growth abnormalities and cancer. Emerging data suggest that the highly conserved Hippo signaling pathway can directly regulate stem cell proliferation and ...
Kriti Shrestha, Fernando D. Camargo
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Hippo signaling for spindle orientation
Science Signaling, 2015The Hippo pathway kinase Warts phosphorylates substrates that control mitotic spindle orientation.
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Hippo Signaling in the Ovary: Emerging Roles in Development, Fertility, and Disease
Endocrine Reviews, 2022Kendra L Clark +2 more
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