Results 171 to 180 of about 33,422 (243)

Peri‐Implantitis and Periodontitis: Biological Convergence, Contextual Divergence

Journal of Periodontal Research, EarlyView.
Periodontal and peri‐implant tissues differ and coincide in many aspects, from the clinical and radiological perspective, including histology, microbiology, and molecular markers. Thus, health and disease may also follow different and similar routes.
Pablo Galindo‐Moreno, Pablo Galindo‐Fernandez, Allinson Olaechea, Francisco O'Valle, Abdusalam E. Alrmali, Hom‐Lay Wang, Miguel Padial‐Molina   +6 more
wiley   +1 more source

iPSC-based drug discovery identified the Hippo signaling pathway as a therapeutic target in the fibrosis of NPHP1-deficient nephronophthisis. [PDF]

Stem Cell Res Ther
Suzuki T, Susa K, Kikuchi H, Nakano Y, Yanagi T, Hara Y, Fujiki T, Ando F, Mandai S, Mori Y, Mori T, Iwasa H, Hata Y, Uchida S, Sohara E.   +14 more
europepmc   +1 more source

The Role of Piezo 1 in the Study of Intervertebral Disc Degeneration: Phenotype, Mechanism and Treatment

Orthopaedic Surgery, EarlyView.
As the key mechanotransducer in IVDD, Piezo1 orchestrates region‐specific degeneration across NP (senescence/ECM dysregulation), AF (apoptosis), and CEP (inflammation). This review integrates mechanistic pathways and assesses multimodal therapeutic targeting (pharmacologic/genetic/nutritional) to restore disc homeostasis.
Guangye Li, Chaoqun Feng, Haoyun Huang, Junwen Deng, Fei Yang, Rigao Chen   +5 more
wiley   +1 more source

Circular RNAs: Unlocking new avenues in cardiometabolic disease management

The Journal of Physiology, EarlyView.
Abstract figure legend In the heart circular RNAs (circRNAs) function as microRNA sponges, interact with proteins and can even undergo translation. Advances in bioinformatics now enable their identification through high‐throughput RNA sequencing, whereas computational analyses reveal differential expression in cardiac disease settings.
Kimberley M. Mellor, Thomas D. Donelly, Gerald L.M. Naepi, Glenn D. Wadley, Bianca C. Bernardo   +4 more
wiley   +1 more source

Pregnancy induces intestinal epithelial elongation and estriol-associated activation of the Hippo signaling pathway in a mouse model. [PDF]

Pflugers Arch
Gängler NF, Knoblauch C, Hill F, Zeeb BL, Falk-Paulsen M, Rosenstiel P, Sievers LK.   +6 more
europepmc   +1 more source

Biomaterial Physical Cues as Gene Regulators for Cellular Agriculture

Advanced Genetics, Volume 7, Issue 2, June 2026.
This review elucidates how biomaterial physical cues—ranging from matrix stiffness to remote electromagnetic fields—serve as extrinsic regulators of gene expression in cellular agriculture. By identifying central mechanotransduction pathways that bridge physical inputs to genetic remodeling, the authors propose the “Material Genome” concept: a ...
Jianuo Liu, Ye Liu
wiley   +1 more source

YAP1 promotes adipogenesis by regulating the negative feedback mechanism of the Hippo signaling pathway via LATS2. [PDF]

Zool Res
Zhou M, Zhao YQ, Yan W, Fu XF, Zhang LH, Zhang HY, Bao GG, Liu DJ.   +7 more
europepmc   +1 more source

Heterokairic Genes and the Eco‐Evo‐Devo of Timing

Evolution &Development, Volume 28, Issue 2, June 2026.
Heterokairic genes as the bridge (Heterokairic Pathways?): Heterokairic genes are heterochronic regulators whose activity is modulated by environmental conditions. External cues (e.g., temperature, nutrition, oxygen, density: yellow box) are sensed (yellow arrows) and converted into endocrine and metabolic signals (purple box and arrow into fish's ...
Leandro Lofeu, Ehsan Pashay Ahi
wiley   +1 more source

Targeting Hippo Signaling Pathway with a Boron Derivative, Sodium Pentaborate Pentahydrate (NaB): Therapeutic Strategies in Colorectal Cancer. [PDF]

Pharmaceuticals (Basel)
Yüksel B, Şahin F, Türkel N.
europepmc   +1 more source

Plasma Proteomics Identifies Thousand‐and‐One–Amino Acid Kinase 3 as a Potential Biomarker of Rheumatoid Arthritis Activity and a Novel Therapeutic Target

Arthritis &Rheumatology, Volume 78, Issue 5, Page 1045-1061, May 2026.
Objective Bone destruction associated with active rheumatoid arthritis (RA) remains a major therapeutic challenge, with a lack of reliable molecular markers reflecting bone injury. This study aims to identify novel biomarkers linked to bone destruction in active RA through proteomic analysis, providing new strategies for precise monitoring and targeted
Pengfei Xin, Wenzhen Li, Xinyu A, Jun Shen, Xiaohui Meng, Yanqin Bian, Haihui Han, Zheng Xiang, Lei Ran, Songtao Sun, Jun Xie, Tao Yue, Qi Zhu, Xiaoming Zhang, Lu Xie, Lianbo Xiao   +15 more
wiley   +1 more source