Results 101 to 110 of about 101,099 (274)

From the Gut to the Brain: Microplastic‐Associated Neurovascular Dysfunction and Implications for Stroke Risk

Advanced Science, EarlyView.
Chronic oral exposure to microplastics may disrupt gut microbiota homeostasis and intestinal barrier integrity, potentially engaging the gut–brain axis and systemic inflammatory responses. These alterations may be associated with impaired blood–brain barrier function, cerebral microvascular dysfunction, and enhanced endothelial inflammation, pro ...
Hongxing Wang, Yujiao He, Pei Zou, Xiaoyi Wang, Gang Peng, Xiangying Deng   +5 more
wiley   +1 more source

How informative are spatial CA3 representations established by the dentate gyrus? [PDF]

, 2009
In the mammalian hippocampus, the dentate gyrus (DG) is characterized by sparse and powerful unidirectional projections to CA3 pyramidal cells, the so-called mossy fibers. Mossy fiber synapses appear to duplicate, in terms of the information they convey,
Cerasti, Erika, Treves, Alessandro
core   +5 more sources

Unveiling a New Link: Cholesterol Deficiency in Smith–Lemli–Opitz and Niemann–Pick C as a Driver of Ciliopathies

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The ciliopathies are a group of genetic disorders caused by defective function of either the primary cilia (a large number) or the motile cilia (a much smaller number). These have been defined as diseases with mutations in genes encoding individual ciliary or cilia‐associated proteins.
Robert P. Erickson, Maria Teresa Fiorenza   +1 more
wiley   +1 more source

L-Lactate Promotes Adult Hippocampal Neurogenesis [PDF]

Frontiers in Neuroscience, 2019
Neurogenesis, the formation of new neurons in the adult brain, is important for memory formation and extinction. One of the most studied external interventions that affect the rate of adult neurogenesis is physical exercise. Physical exercise promotes adult neurogenesis via several factors including brain-derived neurotrophic factor (BDNF) and vascular
Yaeli Lev-Vachnish, Yaeli Lev-Vachnish, Yaeli Lev-Vachnish, Sharon Cadury, Sharon Cadury, Sharon Cadury, Aviva Rotter-Maskowitz, Aviva Rotter-Maskowitz, Aviva Rotter-Maskowitz, Noa Feldman, Noa Feldman, Noa Feldman, Asael Roichman, Tomer Illouz, Tomer Illouz, Alexander Varvak, Raneen Nicola, Raneen Nicola, Ravit Madar, Ravit Madar, Ravit Madar, Eitan Okun, Eitan Okun, Eitan Okun   +23 more
openaire   +3 more sources

The endocannabinoid system regulates both ependymoglial and neuronal cell responses to a tail amputation in the axolotl

Developmental Dynamics, EarlyView.
Abstract Background The endocannabinoid system is a neuromodulatory system implicated in cellular processes during both development and regeneration. The Mexican axolotl, one of only a few vertebrates capable of central nervous system regeneration, was used to examine the role of the endocannabinoid system in the regeneration of the tail and spinal ...
Michael Tolentino, Sarah E. Walker, Gaynor E. Spencer, Robert Carlone   +3 more
wiley   +1 more source

Behavioral and epileptic phenotypes in a CHD2‐related developmental delay model

Epilepsia, EarlyView.
Abstract Objective Heterozygous loss‐of‐function mutations in the CHD2 gene, encoding chromodomain helicase DNA‐binding protein 2, are associated with severe childhood onset epilepsy, global developmental delay, and autistic features. Animal models that accurately recapitulate human phenotypes are crucial for understanding rare neurodevelopmental ...
Anat Mavashov, Shaked Turk, Yael Sarusi, Marina Brusel, Rotem Ben Tov Perry, Shir Quinn, Yael Almog, Karni Vilian, Mor Yam, Igor Ulitsky, Moran Rubinstein   +10 more
wiley   +1 more source

Spatiomechanical Modulation of EphB4-Ephrin-B2 Signaling in Neural Stem Cell Differentiation. [PDF]

, 2018
Interactions between EphB4 receptor tyrosine kinases and their membrane-bound ephrin-B2 ligands on apposed cells play a regulatory role in neural stem cell differentiation.
Chung, Jean, Dong, Meimei, Groves, Jay, Lee, Young, SCHAFFER, David, Spelke, Dawn, Yu, Cheng-Han   +6 more
core   +2 more sources

MicroRNA-9 controls dendritic development by targeting REST [PDF]

, 2014
MicroRNAs (miRNAs) are conserved noncoding RNAs that function as posttranscriptional regulators of gene expression. miR-9 is one of the most abundant miRNAs in the brain.
Akerblom, Akerblom, Ameres, Andres, Aoki, Bak, Ballas, Ballas, Barnes, Bartel, Bonev, Bonhoeffer, Bushati, Caceres, Care, Chen, Chen, Coolen, Coolen, Dajas-Bailador, Delaloy, Dieni, Dotti, Ebert, Edbauer, Feng, Fiore, Gao, Gentner, Giraldez, Goslin, Han, Hand, Haramati, Hering, Hitz, Horch, Jan, Jiang, Jorgensen, Kawabe, Kawauchi, Kluiver, Koch, Kolb, Krichevsky, Kruger, Kuwabara, Laemmli, Lagos-Quintana, Lagos-Quintana, Leucht, Liu, Liu, Liu, London, Loya, Luxenhofer, Ma, Madisen, Magill, Mumm, Nadeau, Olena, Ooi, Otaegi, Packer, Parrish, Parrish, Pathania, Polleux, Qin, Rajan, Refojo, Rodriguez, Saito, Sauvageau, Schoenherr, Schratt, Senyuk, Shibata, Simó, Soriano, Spruston, Sudhof, Takemoto-Kimura, Tronche, Urbanska, Wayman, Whitford, Witkos, Wong, Yamamoto, Yao, Yoo, Zhao   +95 more
core   +1 more source

Insulin‐like growth factor 1 receptor correlates with verbal memory in ILAE type 2 hippocampal sclerosis

Epilepsia, EarlyView.
Abstract Objective Long‐term memory deficits are often seen in patients with temporal lobe epilepsy (TLE). Recently, studies showed that patients with hippocampal sclerosis (HS) type 2, which presents with severe neuron loss in CA1 only, performed within the normal range. However, up to 30% of HS type 2 cases have memory deficits.
Henrique Cruz, Amauri Batista de Oliveira‐Júnior, André Fernando Garcia Cortez, Ricardo Lutzky Saute, Ricardo Silva Centeno, Joao Norberto Stávale, Mirian Salvadori Bittar Guaranha, Elza Marcia Targas Yacubian, Esper Abrão Cavalheiro, Joao Pereira Leite, Jose Eduardo Peixoto‐Santos   +10 more
wiley   +1 more source

Gestational diabetes induces neuronal loss in dentate gyrus in rat offspring [PDF]

, 2014
Background: This study was conducted to determine the effect of gestational diabetes on neuronal density in the dentate gyrus (DG) subfields of hippocampus in rats offspring. Methods: On day 1 of gestation, 10 dams randomly allocated into two control and
Ghafari, S., Golalipour, M.J., Kafshgiri, S.K.   +2 more
core