Results 51 to 60 of about 56,531 (215)

Fine‐Tuned Regulation of mRNA Translation and Transport by STAU2 Condensate Facilitates Neuronal Development and Plasticity

Advanced Science, EarlyView.
STAU2 undergoes phase separation to form dynamic condensates that package target mRNAs and deliver them to the distal ends of growing neuronal dendrites. STAU2 condensates stabilize embedded mRNAs and repress their translation. Synaptic activity bidirectionally remodels STAU2 condensates, coordinating local translation of STAU2‐associated mRNAs ...
Shijing Huang, Yuanyuan Chu, Ruiqian Zhao, Siyu Li, Yu Feng, Hongdan Zheng, Yunli Xie, Tong Wang, Wenyu Wen   +8 more
wiley   +1 more source

Alzheimer’s disease and Hippocampal Adult Neurogenesis; Exploring Shared Mechanisms

Frontiers in Neuroscience, 2016
New neurons incorporate into the granular cell layer of the dentate gyrus throughout life. Neurogenesis is modulated by behavior and plays a major role in hippocampal plasticity.
Orly eLazarov, Carolyn eHollands, Nancy eBartolotti   +2 more
doaj   +1 more source

Role of Wnt Signaling in Adult Hippocampal Neurogenesis in Health and Disease

Frontiers in Cell and Developmental Biology, 2020
Neurogenesis persists during adulthood in the dentate gyrus of the hippocampus. Signals provided by the local hippocampal microenvironment support neural stem cell proliferation, differentiation, and maturation of newborn neurons into functional dentate ...
Sebastian B. Arredondo, Daniela Valenzuela-Bezanilla, Muriel D. Mardones, Lorena Varela-Nallar   +3 more
doaj   +1 more source

Presenilin-1 Dependent Neurogenesis Regulates Hippocampal Learning and Memory. [PDF]

PLoS ONE, 2015
Presenilin-1 (PS1), the catalytic core of the aspartyl protease γ-secretase, regulates adult neurogenesis. However, it is not clear whether the role of neurogenesis in hippocampal learning and memory is PS1-dependent, or whether PS1 loss of function in ...
Jacqueline A Bonds, Yafit Kuttner-Hirshler, Nancy Bartolotti, Matthew K Tobin, Michael Pizzi, Robert Marr, Orly Lazarov   +6 more
doaj   +1 more source

Modification of hippocampal circuitry by adult neurogenesis [PDF]

Developmental Neurobiology, 2012
AbstractThe adult hippocampus is one of the primary neural structures involved in memory formation. In addition to synapse‐specific modifications thought to encode information at the subcellular level, changes in the intrahippocampal neuro‐populational activity and dynamics at the circuit‐level may contribute substantively to the functional capacity of
Juan, Song, Kimberly M, Christian, Guo-li, Ming, Hongjun, Song   +3 more
openaire   +2 more sources

Entacapone promotes hippocampal neurogenesis in mice

Neural Regeneration Research, 2021
Entacapone, a catechol-O-methyltransferase inhibitor, can strengthen the therapeutic effects of levodopa on the treatment of Parkinson's disease. However, few studies are reported on whether entacapone can affect hippocampal neurogenesis in mice. To investigate the effects of entacapone, a modulator of dopamine, on proliferating cells and immature ...
Dae Young Yoo, Hyo Young Jung, Woosuk Kim, Kyu Ri Hahn, Hyun Jung Kwon, Sung Min Nam, Jin Young Chung, Yeo Sung Yoon, Dae Won Kim, In Koo Hwang   +9 more
openaire   +3 more sources

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

Mood Disorder Begins in the Mouth: Periodontitis Mediates Anxiety‐Like Behaviors

Advanced Science, EarlyView.
ABSTRACT The previous study elucidated that the C‐reactive protein (CRP)/bone morphogenetic protein 4 (BMP4) signaling pathway mediates periodontitis‐associated anxiety‐like behaviors in rats. This molecular crosstalk along the periodontal‐hippocampal axis provides novel insights into the etiology and mechanisms of emotional disorders. However, several
Zhigang Chen, Xing Li
wiley   +1 more source

Environmental Enrichment Engages Vesicular Zinc Signaling to Enhance Hippocampal Neurogenesis

Cells, 2023
Zinc is highly concentrated in synaptic vesicles throughout the mammalian telencephalon and, in particular, the hippocampal dentate gyrus. A role for zinc in modulating synaptic plasticity has been inferred, but whether zinc has a particular role in ...
Michael J. Chrusch, Selena Fu, Simon C. Spanswick, Haley A. Vecchiarelli, Payal P. Patel, Matthew N. Hill, Richard H. Dyck   +6 more
doaj   +1 more source

Cdk5 is essential for adult hippocampal neurogenesis [PDF]

Proceedings of the National Academy of Sciences, 2008
The molecular factors regulating adult neurogenesis must be understood to harness the therapeutic potential of neuronal stem cells. Although cyclin-dependent kinase 5 (Cdk5) plays a critical role in embryonic corticogenesis, its function in adult neurogenesis is unknown. Here, we assessed the role of Cdk5 in the generation of dentate gyrus (DG) granule
Diane C, Lagace, David R, Benavides, Janice W, Kansy, Marina, Mapelli, Paul, Greengard, James A, Bibb, Amelia J, Eisch   +6 more
openaire   +2 more sources