Results 31 to 40 of about 56,531 (215)

Inflammasome-IL-1β signaling mediates ethanol inhibition of hippocampal neurogenesis

Frontiers in Neuroscience, 2012
Regulation of hippocampal neurogenesis is poorly understood, but appears to contribute to mood and cognition. Ethanol and neuroinflammation are known to reduce neurogenesis. We have found that ethanol induces neuroinflammation supporting the hypothesis
Fulton eCrews
doaj   +1 more source

Disrupted Neurogenesis in Germ-Free Mice: Effects of Age and Sex

Frontiers in Cell and Developmental Biology, 2020
The gut microbiome has profound effects on development and function of the nervous system. Recent evidence indicates that disruption of the gut microbiome leads to altered hippocampal neurogenesis.
Gavin A. Scott, Dylan J. Terstege, Alex P. Vu, Sampson Law, Alexandria Evans, Jonathan R. Epp   +5 more
doaj   +1 more source

Sustained Activation of the Anterior Thalamic Neurons with Low Doses of Kainic Acid Boosts Hippocampal Neurogenesis

Cells, 2022
Adult hippocampal neurogenesis is prone to modulation by several intrinsic and extrinsic factors. The anterior nucleus (AN) of the thalamus has extensive connections with the hippocampus, and stimulation of this region may play a role in altering ...
Farah Chamaa, Batoul Darwish, Rami Arnaout, Ziad Nahas, Elie D. Al-Chaer, Nayef E. Saadé, Wassim Abou-Kheir   +6 more
doaj   +1 more source

The evolutionary significance of hippocampal neurogenesis [PDF]

European Journal of Neuroscience, 2018
AbstractHippocampal neurogenesis (HN) has been implicated in a variety of hippocampus‐dependent behaviors in the laboratory but its evolutionary significance is still debated. Some authors have argued that HN is an adaptation while others argued it is an atavism.
openaire   +2 more sources

Regulator of G protein signaling 6 mediates exercise-induced recovery of hippocampal neurogenesis, learning, and memory in a mouse model of Alzheimer’s disease

Neural Regeneration Research
Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s disease. Adult hippocampal neurogenesis is reduced in patients with Alzheimer’s disease.
Mackenzie M. Spicer, Jianqi Yang, Daniel Fu, Alison N. DeVore, Marisol Lauffer, Nilufer S. Atasoy, Deniz Atasoy, Rory A. Fisher   +7 more
doaj   +1 more source

Stress Response and Hearing Loss Differentially Contribute to Dynamic Alterations in Hippocampal Neurogenesis and Microglial Reactivity in Mice Exposed to Acute Noise Exposure

Frontiers in Neuroscience, 2021
Noise-induced hearing loss (NIHL) is one of the most prevalent forms of acquired hearing loss, and it is associated with aberrant microglial status and reduced hippocampal neurogenesis; however, the nature of these associations is far from being ...
Qian Li, Hong Li, Xiuting Yao, Conghui Wang, Haiqing Liu, Dan Xu, Chenxi Yang, Hong Zhuang, Yu Xiao, Rui Liu, Sinuo Shen, Shaoyang Zhou, Chenge Fu, Yifan Wang, Gaojun Teng, Lijie Liu   +15 more
doaj   +1 more source

Intermittent hypoxia after transient focal ischemia induces hippocampal neurogenesis and c-Fos expression and reverses spatial memory deficits in rats. [PDF]

PLoS ONE, 2011
Memory impairment is a frequent complication of brain ischemia. Neurogenesis is implicated in learning and memory and is regulated by the transcription factor c-Fos. Preconditioning intermittent hypoxia (IH) attenuates ischemia-related memory impairments,
Yi-Wei Tsai, Yea-Ru Yang, Paulus S Wang, Ray-Yau Wang   +3 more
doaj   +1 more source

TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia

CNS Neuroscience &Therapeutics, EarlyView., 2023
Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi, Decheng Ren, Fan Yuan, Zhou Zhang, Daizhan Zhou, Xin Yi, Lei Ji, Keyi Li, Fengping Yang, Xi Wu, Xingwang Li, Yifeng Xu, Yun Liu, Peng Wang, Changqun Cai, Chuanxin Liu, Qian Ma, Lin He, Yi Shi, Guang He   +19 more
wiley   +1 more source

HDAC1 Regulates Neuronal Differentiation

Frontiers in Molecular Neuroscience, 2022
In adult hippocampal neurogenesis, chromatin modification plays an important role in neural stem cell self-renewal and differentiation by regulating the expression of multiple genes. Histone deacetylases (HDACs), which remove acetyl groups from histones,
Vanesa Nieto-Estevez, Vanesa Nieto-Estevez, Gopakumar Changarathil, Gopakumar Changarathil, Adebayo Olukayode Adeyeye, Adebayo Olukayode Adeyeye, Marissa Olga Coppin, Marissa Olga Coppin, Rawan Serena Kassim, Rawan Serena Kassim, Jingfei Zhu, Jenny Hsieh, Jenny Hsieh   +12 more
doaj   +1 more source

Genetic control of hippocampal neurogenesis.

Genome biology, 2006
Adult neurogenesis in the hippocampus is under complex genetic control. A recent comparative study of two inbred mouse strains using quantitative trait locus analysis has revealed that cell survival is most highly correlated with neurogenesis and identified candidate genes for further investigation.
Pozniak, Christine D, Pleasure, Samuel J
openaire   +2 more sources