Results 21 to 30 of about 56,531 (215)
Role of adult hippocampal neurogenesis in stress resilience
Neurobiology of Stress, 2015 There is a growing appreciation that adult hippocampal neurogenesis plays a role in emotional and cognitive processes related to psychiatric disorders. Although many studies have investigated the effects of stress on adult hippocampal neurogenesis, most ...
Brunno R. Levone +2 more
doaj +1 more source
Exercise-Mediated Neurogenesis in the Hippocampus via BDNF
Frontiers in Neuroscience, 2018 Exercise is known to have numerous neuroprotective and cognitive benefits, especially pertaining to memory and learning related processes. One potential link connecting them is exercise-mediated hippocampal neurogenesis, in which new neurons are ...
Patrick Z. Liu, Robin Nusslock
doaj +1 more source
Adult Neurogenesis and Dendritic Remodeling in Hippocampal Plasticity: Which One is more Important?
Cell Transplantation, 2014 Accumulating knowledge has shown that a decrease in hippocampal neurogenesis is linked to the pathophysiology of mood disorders and some hippocampal-dependent learning and memory tasks.
Suk-Yu Yau, Kwok-Fai So
doaj +1 more source
Frontiers in Neuroscience, 2021 Currently there are approximately 291,000 people suffering from a spinal cord injury (SCI) in the United States. SCI is associated with traumatic changes in mobility and neuralgia, as well as many other long-term chronic health complications, including ...
Arthur Sefiani, Cédric G. Geoffroy
doaj +1 more source
Modulation of Adult Hippocampal Neurogenesis by Sleep: Impact on Mental Health
Frontiers in Neural Circuits, 2017 The process of neurogenesis has been demonstrated to occur throughout life in the subgranular zone (SGZ) of the hippocampal dentate gyrus of several mammals, including humans.
Cristina Navarro-Sanchis +3 more
doaj +1 more source
A new age in understanding adult hippocampal neurogenesis in Alzheimer’s disease
Neural Regeneration Research, 2022 Several lines of evidence have established that proliferation and differentiation of neural stem cells into neurons within the sub-granular zone of the dentate gyrus, a process named adult hippocampal neurogenesis, contribute to maintaining healthy ...
Maya A Hanspal, Sébastien Gillotin
doaj +1 more source
Tau Protein and Adult Hippocampal Neurogenesis [PDF]
Frontiers in Neuroscience, 2012 Tau protein is a microtubule-associated protein found in the axonal compartment that stabilizes neuronal microtubules under normal physiological conditions. Tau metabolism has attracted much attention because of its role in neurodegenerative disorders called tauopathies, mainly Alzheimer disease.
Almudena eFuster-Matanzo +9 more
openaire +5 more sources
Chinese Traditional Medicine and Adult Neurogenesis in the Hippocampus
Journal of Traditional and Complementary Medicine, 2014 Adult neurogenesis is an important therapeutic target in treating neurological disorders. Adult neurogenesis takes place in two regions of the brain: Subventricular zone and dentate gyrus in the hippocampus.
Endong Zhang, Jiangang Shen, Kwok Fai So
doaj +1 more source
Depression and adult hippocampal neurogenesis
Folia Pharmacologica Japonica, 2010 現在，うつ病の治療薬はセロトニンやノルアドレナリンといったモノアミンを増加させる薬剤が中心として用いられているが，脳内の細胞外モノアミン濃度は抗うつ薬の投与数時間後には増加するのに対し，臨床における治療効果発現までには数週間の慢性投与が必要とされることもあり，抗うつ薬の治療発現メカニズムは未だ明らかとされていない．近年，成熟期の脳においても海馬歯状回といった特定領域において，神経幹・前駆細胞が存在し，神経細胞が新生されることが明らかにされている．この海馬における神経新生は，うつ病発症の危険因子とされるストレスによって抑制され，逆に抗うつ薬を慢性投与することによって促進される．さらに，海馬神経新生を阻害すると，行動薬理評価モデルにおける抗うつ薬の作用が消失するなどの報告から ...
Masuda, Takahiro +2 more
openaire +3 more sources
Dynamics of Hippocampal Neurogenesis in Adult Humans [PDF]
Cell, 2013 Adult-born hippocampal neurons are important for cognitive plasticity in rodents. There is evidence for hippocampal neurogenesis in adult humans, although whether its extent is sufficient to have functional significance has been questioned. We have assessed the generation of hippocampal cells in humans by measuring the concentration of nuclear-bomb ...
Spalding, Kirsty L +13 more
openaire +4 more sources