Results 71 to 80 of about 101,099 (274)
Aerobic Exercise Promotes Hippocampal Neurogenesis and Ameliorates Cognitive Dysfunction Induced by Unilateral Labyrinthectomy. [PDF]
CNS Neurosci TherUL induced significant spatial and non‐spatial cognitive dysfunction and hippocampal neurogenesis inhibition, whereas aerobic exercise intervention effectively reversed these impairments. Transcriptomic profiling and pharmacological evidence identified MHC class I/II–related pathways (H2‐K1, H2‐Eb1, CD74) as key mediators of the restorative effects of ...
Zhou Z +13 more
europepmc +2 more sources
Radiation-induced lowered neurogenesis associated with shortened latency of inhibitory avoidance memory response [PDF]
, 2011 The neural system is less sensitive to radiation than other late-responding organs and tissues such as the kidney and lung. The generation of new neurons in the adult mammalian brain has been documented in several works.
Azami, N.S. +3 more
core
The impact of fruit flavonoids on memory and cognition [PDF]
, 2010 There is intense interest in the studies related to the potential of phytochemical-rich foods to prevent age-related neurodegeneration and cognitive decline.
Bhat +10 more
core +1 more source
Advanced Science, EarlyView.This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia +6 more
wiley +1 more source
Effect of filgrastim (Recombinant human granulocyte colony stimulating factor) on spatial memory in aged rats [PDF]
, 2015 Background: Apart from functioning as a multimodal hematopoietic growth factor, granulocyte colony-stimulating factor (G-CSF) causes intense consequences on the brain.
Mehrazin, E., Sepehri, H.
core +1 more source
Adult Neurogenesis Conserves Hippocampal Memory Capacity [PDF]
The Journal of Neuroscience, 2018 The hippocampus is crucial for declarative memories in humans and encodes episodic and spatial memories in animals. Memory coding strengthens synaptic efficacy via an LTP-like mechanism. Given that animals store memories of everyday experiences, the hippocampal circuit must have a mechanism that prevents saturation of overall synaptic weight for the ...
Md Jahangir Alam +5 more
openaire +2 more sources
Advanced Science, EarlyView.Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu +14 more
wiley +1 more source
Alzheimer’s disease and Hippocampal Adult Neurogenesis; Exploring Shared Mechanisms
Frontiers in Neuroscience, 2016 New neurons incorporate into the granular cell layer of the dentate gyrus throughout life. Neurogenesis is modulated by behavior and plays a major role in hippocampal plasticity.
Orly eLazarov +2 more
doaj +1 more source
Role of Wnt Signaling in Adult Hippocampal Neurogenesis in Health and Disease
Frontiers in Cell and Developmental Biology, 2020 Neurogenesis persists during adulthood in the dentate gyrus of the hippocampus. Signals provided by the local hippocampal microenvironment support neural stem cell proliferation, differentiation, and maturation of newborn neurons into functional dentate ...
Sebastian B. Arredondo +3 more
doaj +1 more source
Presenilin-1 Dependent Neurogenesis Regulates Hippocampal Learning and Memory. [PDF]
PLoS ONE, 2015 Presenilin-1 (PS1), the catalytic core of the aspartyl protease γ-secretase, regulates adult neurogenesis. However, it is not clear whether the role of neurogenesis in hippocampal learning and memory is PS1-dependent, or whether PS1 loss of function in ...
Jacqueline A Bonds +6 more
doaj +1 more source