Results 181 to 190 of about 633,597 (336)

Galanin inhibits acetylcholine release in the ventral hippocampus of the rat: histochemical, autoradiographic, in vivo, and in vitro studies. [PDF]

open access: bronze, 1987
Gilberto Fisone   +7 more
openalex   +1 more source

Allele‐Specific Regulation of PAXIP1‐AS1 by SMC3/CEBPB at rs112651172 in Psychiatric Disorders Drives Synaptic and Behavioral Dysfunctions in Mice

open access: yesAdvanced Science, EarlyView.
This study identifies a functional noncoding variant, rs112651172 (C/G), that drives allele‐specific expression of PAXIP1‐AS1 in monozygotic twin pairs discordant for schizophrenia and bipolar disorder. The risk G allele enhances CEBPB binding, leading to lncRNA upregulation, CNTNAP3 derepression, and synaptic and behavioral deficits in mice.
Chaoying Ni   +14 more
wiley   +1 more source

Estrogen Alleviates Sevoflurane‐Induced Neurotoxicity by Inhibiting ERα‐Tau Binding

open access: yesAdvanced Science, EarlyView.
Sevoflurane‐induced neurotoxicity exhibits sex differences, and estrogen can mitigate these effects; however, its protective action appears to be time‐window dependent, which may be related to the competitive binding of estrogen and Tau to ERα. Abstract Sevoflurane‐induced neurotoxicity is age‐dependent, but the role of sex differences is unclear ...
Feixiang Li   +8 more
wiley   +1 more source

Nicotinic acetylcholine receptors in cultured neurons from the hippocampus and brain stem of the rat characterized by single channel recording [PDF]

open access: bronze, 1987
Yasco Aracava   +6 more
openalex   +1 more source

Clinically Inspired Multimodal Treatment Using Induced Neural Stem Cells‐Derived Exosomes Promotes Recovery of Traumatic Brain Injury through Microglial Modulation

open access: yesAdvanced Science, EarlyView.
This study explores the therapeutic potential of iNSC‐Exo via local and systemic delivery in TBI mice. It is found that iNSC‐Exo enhances NRXN signaling through Microglia_Nrg3 and Microglia_Rarb, effectively promoting functional and neurological recovery, suggesting a new therapeutic strategy for TBI. Abstract Traumatic brain injury (TBI) poses serious
Jiaojiao Li   +9 more
wiley   +1 more source

SpaBatch: Deep Learning‐Based Cross‐Slice Integration and 3D Spatial Domain Identification in Spatial Transcriptomics

open access: yesAdvanced Science, EarlyView.
SpaBatch is an end‐to‐end multi‐slice spatial transcriptomics data integration framework. It simultaneously performs embedding learning, spatial feature denoising and reconstruction, batch effect correction, and spatial domain optimization, effectively correcting batch effects and achieving accurate 3D spatial domain identification.
Jinyun Niu   +5 more
wiley   +1 more source

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