Results 111 to 120 of about 7,899 (213)

PO52 | Comprehensive assessment of variables affecting spontaneous platelet aggregation

Bleeding, Thrombosis and Vascular Biology
Background and Aims: Platelets in citrate-plasma from some subjects aggregate in light transmission aggregometer (LTA) without stimulation by exogenous agonists («spontaneous platelet aggregation», SPA).
doaj   +1 more source

Effect of recombinant hirudin, a specific inhibitor of thrombin, on endotoxin-induced intravascular coagulation and acute lung injury in pigs [PDF]

, 1990
Siebeck, Matthias, Weipert, J., Geiger, R., Spannagl, Michael, Jochum, Marianne, Fritz, Hans, Hoffmann, H.   +6 more
core  

Effects of hirudin-induced activation of nonenzymatic fibrinolysis during immobilization stress

, 1980
The specific inhibitor of thrombin, hirudin, was used for studying the mechanism of the activating effect of ACTH and adrenalin on nonenzymatic fibrinolytic activity (NEFA), the latter characterizing the function of the anticoagulation system (ACS ...
Baskova, I. P., Goldovskaya, M. D., Shapiro, F. B., Cherkesova, L. U., Lyapina, L. A.   +4 more
core  

Case report: Heparin coagulant super-sensitivity during leech therapy. [PDF]

Thromb J
Rong Z, Daniels A, Luu K, Czerwonka L, Bahou WF.   +4 more
europepmc   +1 more source

The pharmacology of recombinant hirudin, a new anticoagulant

, 2017
A new anticoagulant, recombinant hirudin, was given to healthy volunteers (5 per test dose) in single .intravenous doses of 0,01, 0,02, 0,04, 0,07 and 0,1 mg/kg to study its anticoagulant effects, how it was tolerated and its pharmacokinetics.
Muller, F.O., Rothig, H.J., Badenhorst, P.N., Meyer, B.H., Luus, H.G.   +4 more
core  

The great diversity: monomeric and oligomeric hirudins, hirudin-like factors and decorsins in the Asian medicinal leeches Hirudo nipponia and Hirudo tianjinensis. [PDF]

Parasitol Res
Kalatehjari P, Wolf R, Jedlitschky G, Tolksdorf C, Rauch BH, Müller C.   +5 more
europepmc   +1 more source

The C-terminal binding domain of hirullin P18. Antithrombin activity and comparison to hirudin peptides

, 2009
[[abstract]]Hirullin P18 is a 61-amino acid hirudin-related protein having potent antithrombin activity. Similar to hirudin, it contains a highly acidic C-terminus, but has a significantly different sequence from any other known hirudin variant.
Krstenansky JL; Owen TJ; Yates MT; Mao SJT
core  

Hirudin suppresses hematogenous metastasis by targeting desmosome junction transition in circulating tumor cell clusters via HIF-1α-DSG2 signaling. [PDF]

Exp Mol Med
Zou J, Shi J, Chen Q, Zhu Z, Hu T, Zhang Z, Pan Z, Xu F, Zhu Y, Wu Y, Zhao Y, Wang A, Lu Y, Pan Y, Chen W.   +14 more
europepmc   +1 more source

Aptamer-thrombin loaded magnetic microspheres for bio-specific extraction and precise detection of hirudin

Hirudin, that is naturally occurring in leeches (Hirudo medicinalis) and known as the most potent natural inhibitor of thrombin, exerts double-edged effects in clinic application.
Shang, Chunqing, Xiujun Cao, Song, Guoxin, Yuan Luo, Deng, Chunhui, Chunqing Shang, Jun Lu, Luo, Yuan, Xueli Liu, Lu, Jun, Cao, Xiujun, Guoxin Song, Liu, Xueli, Chunhui Deng   +13 more
core   +1 more source

Beyond Folding Enzymes: A Redox-Active "Solid Chaperone" Unlocks Recyclable, HPLC-Free Oxidative Protein Folding. [PDF]

JACS Au
Iwamoto S, Nishizawa Y, Yokose H, Kanie O, Okamura Y, Muraoka T, Arai K.   +6 more
europepmc   +1 more source