Results 101 to 110 of about 7,899 (213)

Pharmacokinetics of rec-hirudin in healthy volunteers after intravenous administration.

, 1994
The pharmacokinetics of recombinant hirudin (rec-hirudin, Ciba-Geigy, CGP 39,393) in healthy volunteers after iv administration was investigated on the basis of the data from five different studies.
Godbillon, J A, Cardot, J M, Lefevre, Gilbert   +2 more
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Scale-up of recombinant hirudin production from Saccharomyces cerevisiae

, 2003
Scale-up of hirudin production from Saccharomyces cerevisiae from bench-scale to pilot-scale was carried out based on constant volumetric oxygen transfer coefficient (KLa).
K J Rao, Sang Ki Rhee, D J Youn, Chul Ho Kim   +3 more
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Hirudin versus heparin for anticoagulation in continuous renal replacement therapy

, 2001
Objective: To compare the efficacy and safety of hirudin and heparin for anticoagulation during continuous renal replacement therapy (CRRT) in critically ill patients. Design: Prospective, randomized controlled pilot study.
Hein OV, Kox WJ, Welte M, Ronco C, Neumayer HH, Morgera S, Lipps M, Ziemer S, Spies C, von Heymann C   +9 more
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Effect of hirudin versus heparin on hemocompatibility of blood contacting biomaterials : an in vitro study

, 2005
Hirudin serves as an alternative anticoagulant for extracorporeal blood circulation. Comparing anticoagulation with hirudin (2.5 or 5.0 μg/mL) and heparin (2.0 or 4.0 IU/mL) human blood was circulated in a modified “Chandler System” using PVC-tubes for ...
Kashefi, A., K. Mottaghy, R. Bensberg, Mottaghy, Khosrow, Rossaint, Rolf, R. Rossaint, R. Kopp, A. Kashefi, Kuhlen, Ralf, R. Kuhlen, Bernsberg, R., Kopp, Rüdger   +11 more
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Cloning, Expression of Hirudin Gene from Leech (Hirudo orientalis) in BL21(DE3) Strain

, 2017
The use of leeches in bloodletting therapy is one of the most important techniques in ancient medicine from Greek time up to now. Leeches saliva contain anticoagulant hirudin which facilitate blood flow, this is one reason for using leeches to save ...
Al-Fadal, Sabaa, Al-Badran, Adnan
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Expression of hirudin fusion proteins in mammalian cells : A strategy for prevention of intravascular thrombosis

, 1998
Background - Intravascular thrombosis occurs in disorders of diverse pathogeneses, including allograft and xenograft rejection. In this in vitro study, we describe an approach for tethering the specific thrombin inhibitor hirudin to plasma membranes as ...
George, Andrew J.T., John H. McVey, Edward G. D. Tuddenham, Geoffrey Kemball-Cook, Lechler, Robert I.,, Lechler, Robert I., Tuddenham, Edward G.D., Anthony Dorling, Kristian Riesbeck, George, Andrew J.T.,, Dorling, Anthony,, Dorling, Anthony, Daxin Chen, Robert I. Lechler, Kemball-Cook, Geoffrey,, Chen, Daxin, Andrew J. T. George, Chen, Daxin,, Kemball-Cook, Geoffrey, McVey, John H., Tuddenham, Edward G.D.,, Riesbeck, Kristian,, Lund University., McVey, John H.,, Riesbeck, Kristian   +24 more
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Preparation of Hirudin-Loaded Chitosan/Polycaprolactone Bowl-Shaped Particles and an Application for a Drug Delivery System

Applied Sciences
Atherosclerosis, a disease that mainly affects human blood vessels, can cause various cerebral ischaemic diseases such as coronary heart disease and peripheral arterial disease.
Xiang Li, Xin Zhang, Wei Zhao, Peng Tian, Kelimu Tulugan   +4 more
doaj   +1 more source

Hirudin Protects Against Kidney Damage in Streptozotocin-Induced Diabetic Nephropathy Rats by Inhibiting Inflammation via P38 MAPK/NF-κB Pathway

Drug Design, Development and Therapy, 2020
Jiarui Han,1,2 Xinxin Pang,1,2 Yage Zhang,1,2 Zining Peng,1,2 Xiujie Shi,1,2 Yufeng Xing1,2 1Department of Nephropathy, Henan Provincial Hospital of Traditional Chinese Medicine, Zhengzhou, Henan Province, People’s Republic of China; 2Department of
Han J, Pang X, Zhang Y, Peng Z, Shi X, Xing Y   +5 more
doaj  

Successful Use of Alternative Anticoagulants in the Management of Heparin-induced Thrombocytopenia with Thrombotic Complications : Report of 5 cases and review of literature

Sultan Qaboos University Medical Journal, 2011
Heparin is one of the most frequently used anticoagulants. It is easy to use, but can be associated with life-threatening side effects. One of these is heparin-induced thrombocytopenia syndrome (HITS), which develops in about 3–5% of patients exposed to ...
Salam Alkindi, Owen P Smith, Helen Enright   +2 more
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The Structure of a Complex of Bovine &-Thrombin and Recombinant Hirudin at 2.8-A Resolution

, 1992
Crystals of the complex of bovine alpha-thrombin with recombinant hirudin variant 1 have space group C222(1) with cell constants a = 59.11, b = 102.62, and c = 143.26 A.
Edwards, Brian F.P., Johnson, Paul H, Vitali, Jacqueline, Winant, Richard C, Lazar, Jerome B, Martin, Philip D., Lazar, Jerome B., Edwards, Brian FP, Robertson, William D, Robertson, William D., Malkowski, Michael G, Malkowski, Michael G., Winant, Richard C., Johnson, Paul H., Martin, Philip D   +14 more
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