Jalaukāvacaraṇa (Hirudo therapy) in the management of necrosed index finger due to crush injury
Ancient Science of Life, 2018 Necrosis of tissue has become the challenging case, considering the difficulties of its management to bring back the normalcy of dead tissue. Treatment choice in surgery ends up with amputation of the affected part which leads to depression to a patient.
Dudhamal Tukaram Sambhaji +1 more
doaj +1 more source
A randomized clinical trial of unfractioned heparin for treatment of sepsis (the HETRASE study): design and rationale [NCT00100308] [PDF]
, 2006 Introduction Infection promotes coagulation via a large number of molecular and cellular mechanisms, and this procoagulant activity has boosted basic and clinical research using anticoagulant molecules as therapeutic tools in sepsis.
Aguirre Daniel +6 more
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Hirudin in the Treatment of Chronic Kidney Disease
MoleculesChronic kidney disease (CKD) is a common public health concern. The global burden of CKD is increasing due to the high morbidity and mortality associated with it, indicating the shortcomings of therapeutic drugs at present.
Sai-Ji Liu, Yi-Ling Cao, Chun Zhang
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Ingestive behaviour and physiology of the medicinal leech [PDF]
, 1988 Ingestion lasts 25 min in Hirudo medicinalis and is characterized by pharyngeal peristalsis which fills the crop. This peristalsis has an initial rate of 2.4 Hz which decays smoothly to 1.2 Hz at termination of ingestion. During ingestion, the leech body
Dickinson, M. H. +3 more
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Research progress on the treatment of diabetic nephropathy with leech and its active ingredients
Frontiers in EndocrinologyDiabetic nephropathy (DN) is a major microvascular complication of diabetes and a common cause of chronic kidney disease. There is currently a lack of effective treatments for DN, and the prognosis for patients remains poor.
Feng Tian +6 more
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Argatroban During Percutaneous Transluminal Coronary Angioplasty: Results of a Dose-Verification Study. [PDF]
, 1996 Background. Thrombin is a key enzyme in thrombogenesis. In animals, specific antithrombotic therapy at the time of coronary angioplasty reduced the incidence of subacute occlusion and inhibited the restenosis response.
Gabriel, L. +5 more
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Endogenous t-PA release and pharmacological thrombolysis - Experimental animal studies of the coronary circulation [PDF]
, 2006 The physiologically most important activator of intravascular fibrinolysis is tissue-type plasminogen activator (t-PA) released from endothelial cells. In man, sympathomimetic drugs increase the systemic concentration of t-PA. It is therefore of interest
Björkman, Jan-Arne
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Parmodulins Inhibit Thrombus Formation Without Inducing Endothelial Injury Caused by Vorapaxar [PDF]
, 2015 Protease-activated receptor-1 (PAR1) couples the coagulation cascade to platelet activation during myocardial infarction and to endothelial inflammation during sepsis. This receptor demonstrates marked signaling bias.
Ahn +52 more
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International Journal of Medical Sciences, 2012 Aim: To evaluate the efficacy and safety of donepezil plus natural hirudin in patients with mild-to-moderate Alzheimer's Disease. Methods: In the 20-week, randomized, open-label and controlled study, 84 patients received either donepezil (5 mg/day for ...
De-qiang Li, Yu-ping Zhou, Han Yang
doaj
Protective Effect and Molecular Mechanism of Hirudin on Kidney of Diabetic Rats
Xiehe Yixue ZazhiObjective To investigate the protective effect of hirudin on kidneys of diabetic rats and its molecular mechanism. Methods Eighteen Sprague-Dawley rats were randomly divided into control group (n=5) and model group (n=13).
HE Yiqian +4 more
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