Results 81 to 90 of about 7,899 (213)

Recombinant hirudin - a specific thrombin inhibiting anticoagulant for hemodialysis.

, 1994
Recombinant hirudin: A specific thrombin inhibiting anticoagulant for hemodialysis. The first experience with hirudin as an alternative anticoagulant for heparin in hemodialysis is reported.
Ringoir, Severin, Mirshahi, Manouchehr, Vanholder, Raymond, CAMEZ, AA, MIRSHAHI, M, Soria, Jeannette, Camez, Anne A., Vanholder, Raymond C., Veys, Nic M., Veys, Nic, Soria, Claudine, SORIA, J, SORIA, C   +12 more
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Cell-free synthesis of the hirudin variant 1 of the blood-sucking leech Hirudo medicinalis

, 2022
Art. 19818, 13 S.Synthesis and purification of peptide drugs for medical applications is a challenging task. The leech-derived factor hirudin is in clinical use as an alternative to heparin in anticoagulatory therapies.
Lukas, P., Müller, C., Wüstenhagen, D.A., Aubele, S.A., Kubick, S., Hildebrandt, J.-P.   +5 more
core   +1 more source

Research progress on the treatment of diabetic nephropathy with leech and its active ingredients

Frontiers in Endocrinology
Diabetic nephropathy (DN) is a major microvascular complication of diabetes and a common cause of chronic kidney disease. There is currently a lack of effective treatments for DN, and the prognosis for patients remains poor.
Feng Tian, Xiang Yi, Feifei Yang, Yao Chen, Wenhui Zhu, Peng Liu, Shuju Li   +6 more
doaj   +1 more source

The Antithrombotic Effect of Recombinant Neorudin on Thrombi

Drug Design, Development and Therapy, 2022
Yu-Bin Liu,1 Lin Zhang,1 Xing-Chen Zhou,1 Ying Zhou,1 Yun Liu,1 Can Zheng,1 Xiao Xu,1 Pan-Pan Geng,1 Chun-Hua Hao,2 Zhuan-You Zhao,2 Chu-Tse Wu,1 Ji-De Jin1 1Department of Experimental Hematology and Biochemistry, Beijing Institute of Radiation Medicine,
Liu YB, Zhang L, Zhou XC, Zhou Y, Liu Y, Zheng C, Xu X, Geng PP, Hao CH, Zhao ZY, Wu CT, Jin JD   +11 more
doaj  

Jalaukāvacaraṇa (Hirudo therapy) in the management of necrosed index finger due to crush injury

Ancient Science of Life, 2018
Necrosis of tissue has become the challenging case, considering the difficulties of its management to bring back the normalcy of dead tissue. Treatment choice in surgery ends up with amputation of the affected part which leads to depression to a patient.
Dudhamal Tukaram Sambhaji, Komang Sudarmi   +1 more
doaj   +1 more source

The recombinant hirudin concentration in plasma by ELISA.

, 2013
The concentration–time curve of recombinant hirudin in the plasma of rats that had been injected intravenously with 125I-recombinant hirudin, as determined by ELISA. Each point represents mean±SD (n = 4).
Su-yun Jiang (421688), Ting-ting Zhang (421689), Yong-ping Xu (421690), Jian Jiao (364961)   +3 more
core   +1 more source

The recombinant hirudin concentration in plasma by CSA.

, 2013
The concentration–time curve of recombinant hirudin in the plasma of rats that had been injected intravenously with 125I-recombinant hirudin, as determined by the chromogenic substrate assay. Each point represents mean±SD (n = 5).
Su-yun Jiang (421688), Ting-ting Zhang (421689), Yong-ping Xu (421690), Jian Jiao (364961)   +3 more
core   +1 more source

Production and purification of constructed recombinant hirudin in BL21(DE3) strain

, 2017
Background/Objective: Hirudin, an extract from the leech, has powerful antithrombin activity affecting the blood coagulation pathway, it is the most potent natural inhibitor of thrombin, it binds thrombin with high affinity, so, the aim of this study was
Sabaa Ali Al-Fadal, Adnan I. Al-Badran
core   +1 more source

The anticoagulant mechanism of action of recombinant hirudin (CGP 39393) in plasma [PDF]

, 1990
We studied the inhibitory action of recombinant desulphatohirudin (CGP 39393) on thrombin generation in whole plasma. Human plasma was activated either with thromboplastin or factor IXa.
Hemker, H. Coenraad, Lindhout, Theo, Blezer, Ron   +2 more
core   +1 more source

Donepezil Combined with Natural Hirudin Improves the Clinical Symptoms of Patients with Mild-to-Moderate Alzheimer's Disease: A 20-Week Open-Label Pilot Study

International Journal of Medical Sciences, 2012
Aim: To evaluate the efficacy and safety of donepezil plus natural hirudin in patients with mild-to-moderate Alzheimer's Disease. Methods: In the 20-week, randomized, open-label and controlled study, 84 patients received either donepezil (5 mg/day for ...
De-qiang Li, Yu-ping Zhou, Han Yang
doaj